novobiocin

简明释义

英[ˌnəʊvəʊˈbaɪəsɪn]美[ˌnoʊvəˈbaɪəsɪn]

n. [药] 新生霉素

英英释义

单词用法

同义词

反义词

例句

1.Objective To study the antitumor activity of noviose and coumarin in novobiocin.

目的研究新生霉素的结构单元诺维糖和香豆素的抗肿瘤活性。

2.Objective To study the antitumor activity of otiose and coumarin in novobiocin.

目的研究新生霉素的结构单元诺维糖和香豆素的抗肿瘤活性。

3.Objective To study the antitumor activity of noviose and coumarin in novobiocin.

目的研究新生霉素的结构单元诺维糖和香豆素的抗肿瘤活性。

4.Novobiocin can be used as a second-line treatment for certain urinary tract infections.

novobiocin可作为某些尿路感染的二线治疗药物。

5.Researchers are studying the mechanism of action of novobiocin in bacterial cells.

研究人员正在研究novobiocin在细菌细胞中的作用机制。

6.The combination of novobiocin with other antibiotics may enhance its effectiveness.

novobiocin与其他抗生素的联合使用可能增强其效果。

7.In clinical trials, novobiocin showed promise for treating resistant bacterial infections.

在临床试验中，novobiocin显示出治疗耐药性细菌感染的潜力。

8.The antibiotic novobiocin is effective against certain strains of staphylococci.

抗生素novobiocin对某些金黄色葡萄球菌株有效。

作文

Novobiocin, a type of antibiotic, has been used in the treatment of various bacterial infections. This compound is derived from the bacterium Streptomyces niveus and was first discovered in the 1950s. The primary mechanism of action of novobiocin is to inhibit bacterial DNA gyrase, an essential enzyme that helps in DNA replication and transcription. By interfering with this process, novobiocin effectively prevents the growth and reproduction of bacteria, making it a valuable tool in combating infections caused by susceptible strains.In clinical settings, novobiocin has been particularly effective against certain Gram-positive bacteria, including Staphylococcus saprophyticus, which is known to cause urinary tract infections. The effectiveness of novobiocin against this pathogen has made it a preferred choice for treating such infections, especially in young women who are more prone to these types of bacterial invasions.However, the use of novobiocin is not without its challenges. Over the years, there have been reports of increasing resistance among bacteria, which poses a significant concern in the medical community. Resistance can occur through various mechanisms, including the alteration of drug target sites or the production of enzymes that degrade the antibiotic. As a result, while novobiocin remains a useful antibiotic, its efficacy is sometimes compromised by the emergence of resistant strains.Research continues to explore the potential of novobiocin in combination therapies, where it may be used alongside other antibiotics to enhance its antibacterial effects. Such strategies aim to reduce the likelihood of resistance development and improve treatment outcomes for patients suffering from serious infections. Moreover, ongoing studies are investigating the structural modifications of novobiocin to create new derivatives that may have enhanced potency against resistant bacterial strains.In addition to its antimicrobial properties, novobiocin has also been studied for its potential applications in cancer therapy. Some research suggests that novobiocin may possess anti-cancer properties due to its ability to inhibit certain cellular processes involved in tumor growth. While this area of study is still in its infancy, the dual potential of novobiocin as both an antibiotic and a therapeutic agent for cancer highlights the importance of ongoing research into this compound.In conclusion, novobiocin is a noteworthy antibiotic with a rich history and a promising future. Its role in treating specific bacterial infections, particularly those caused by Gram-positive organisms, underscores its clinical significance. However, the rise of antibiotic resistance presents a formidable challenge that necessitates continued vigilance and innovation in treatment strategies. As researchers delve deeper into the mechanisms of novobiocin and its potential applications beyond traditional antibiotic use, we may uncover new avenues for improving patient care and combating infectious diseases effectively.

诺沃比星是一种抗生素，已被用于治疗各种细菌感染。这种化合物源自细菌Streptomyces niveus，并于20世纪50年代首次发现。novobiocin的主要作用机制是抑制细菌DNA旋转酶，这是一种在DNA复制和转录中起重要作用的酶。通过干扰这一过程，novobiocin有效地阻止了细菌的生长和繁殖，使其成为对抗易感菌株感染的有价值工具。在临床环境中，novobiocin对某些革兰氏阳性细菌特别有效，包括引起尿路感染的金黄色葡萄球菌。novobiocin对这种病原体的有效性使其成为治疗此类感染的首选，尤其是在年轻女性中，她们更容易受到这些类型细菌入侵的影响。然而，novobiocin的使用并非没有挑战。多年来，关于细菌耐药性增加的报告引起了医学界的重大关注。耐药性可以通过多种机制发生，包括药物靶位点的改变或产生降解抗生素的酶。因此，尽管novobiocin仍然是一种有用的抗生素，但其疗效有时会因耐药菌株的出现而受到影响。研究继续探索novobiocin在联合治疗中的潜力，即与其他抗生素一起使用，以增强其抗菌效果。这些策略旨在减少耐药性发展的可能性，提高严重感染患者的治疗结果。此外，正在进行的研究正在调查novobiocin的结构修饰，以创造出可能对耐药细菌株具有增强效力的新衍生物。除了其抗微生物特性外，novobiocin还被研究其在癌症治疗中的潜在应用。一些研究表明，novobiocin可能具有抗癌特性，因为它能够抑制肿瘤生长相关的某些细胞过程。虽然这一研究领域仍处于初期阶段，但novobiocin作为抗生素和癌症治疗剂的双重潜力突显了对该化合物持续研究的重要性。总之，novobiocin是一种值得注意的抗生素，拥有丰富的历史和光明的未来。它在治疗特定细菌感染，特别是由革兰氏阳性生物引起的感染中的作用强调了其临床重要性。然而，抗生素耐药性的上升带来了严峻的挑战，这需要在治疗策略上持续保持警惕和创新。随着研究人员深入探讨novobiocin的机制及其在传统抗生素使用之外的潜在应用，我们可能会发现改善患者护理和有效对抗传染病的新途径。