quinolone

简明释义

英[ˈkwɪnəˌloʊn]美[ˈkwɪnəˌloʊn]

n. 喹诺酮

英英释义

单词用法

同义词

反义词

例句

1.If there is an allergy to penicillin, physicians should consider azithromycin or a respiratory quinolone.

如果对青霉素过敏，医师们应该考虑阿奇霉素或呼吸喹诺酮。

2.AIM: To design and prepare quinolone compounds with antibacterial and antitumor activities.

目的：设计合成有抗菌抗肿瘤活性的喹诺酮药物。

3.The contents of quinolone medicines such as ofloxacin etc in aqueous solution are analyzed by ion inhibition chromatography.

用离子抑制色谱进行水溶液中氧氟沙星等喹诺酮类药物含量的分析。

4.Do antibiotics sensitivity test on its recombinant strains, but no resistance of Quinolone can be found.

药敏试验结果表明，重组菌株失去对喹诺酮类药物的抗药性。

5.The onset of the great cause epilepsy quinolone drugs.

导致癫痫大发作的喹诺酮类药品。

6.Progresses on the synthesis and classification of the metal complexes based on quinolone antibacterial drugs, their structures, properties as well as their reaching trend in future are reviewed.

本文综述了喹诺酮类抗菌药物金属配合物的合成、分类、结构、性质等方面的研究现状，展望了此类研究的发展趋势。

7.Objective To investigate the impact of non target gene mutations and reduced permeability of the outer membrane on quinolone resistance and multiple antibiotic resistance (mar) in Escherichia coli.

目的：探讨非靶位基因突变及外膜通透性改变对大肠杆菌喹诺酮类耐药和多重耐药的影响。

8.OBJECTIVE to study the mutation in DNA gyrase a of Escherichia coli resistante to quinolone antibiotics.

目的研究导致大肠埃希菌dna回旋酶a亚单位的基因变异耐喹诺酮类药物的机制。

9.Methods Retrospective analysis of 736 cases reported in the literature about quinolone adverse drug reaction was made.

方法采用回顾性分析的方法，对文献报道的736例喹诺酮类抗菌药物不良反应样本案例进行统计分析。

10.The doctor prescribed a course of quinolone 喹诺酮类抗生素 to treat the bacterial infection.

医生开了一疗程的quinolone 喹诺酮类抗生素来治疗细菌感染。

11.The effectiveness of quinolone 喹诺酮类抗生素 can be reduced if taken with certain antacids.

如果与某些抗酸药一起服用，quinolone 喹诺酮类抗生素的有效性可能会降低。

12.Patients allergic to quinolone 喹诺酮类抗生素 should inform their healthcare provider before starting treatment.

对quinolone 喹诺酮类抗生素过敏的患者在开始治疗前应告知医疗提供者。

13.Some side effects of quinolone 喹诺酮类抗生素 include nausea and dizziness.

一些quinolone 喹诺酮类抗生素的副作用包括恶心和头晕。

14.In some cases, quinolone 喹诺酮类抗生素 is used to treat urinary tract infections.

在某些情况下，quinolone 喹诺酮类抗生素用于治疗尿路感染。

作文

Quinolones are a class of synthetic antibiotics that have been widely used in the treatment of various bacterial infections. These compounds are characterized by their bicyclic structure, which includes a quinoline moiety. The discovery of the first quinolone, nalidixic acid, in the 1960s marked the beginning of a new era in antibiotic therapy. Since then, numerous derivatives have been developed, expanding the range of bacterial infections that can be treated effectively. The mode of action of quinolone (喹诺酮) antibiotics involves the inhibition of bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for DNA replication and transcription. This mechanism leads to the disruption of bacterial growth and ultimately results in cell death.One of the significant advantages of quinolone (喹诺酮) antibiotics is their broad-spectrum activity, which means they can target a wide variety of Gram-positive and Gram-negative bacteria. This makes them particularly useful in treating infections that are resistant to other classes of antibiotics. For instance, fluoroquinolones, a subclass of quinolone (喹诺酮), such as ciprofloxacin and levofloxacin, are commonly prescribed for urinary tract infections, respiratory infections, and even certain skin infections.Despite their effectiveness, the use of quinolone (喹诺酮) antibiotics has raised concerns regarding side effects and the potential for developing antibiotic resistance. Some patients may experience adverse effects such as gastrointestinal disturbances, central nervous system effects, and tendon damage. Furthermore, the overuse and misuse of these antibiotics have contributed to the emergence of resistant bacterial strains, making it increasingly challenging to treat infections that were once easily managed with quinolone (喹诺酮) antibiotics.To mitigate these issues, healthcare providers are encouraged to prescribe quinolone (喹诺酮) antibiotics judiciously and only when necessary. It is also essential for patients to adhere to the prescribed treatment regimen to ensure the complete eradication of the infection and minimize the risk of resistance. Research is ongoing to develop new quinolone (喹诺酮) derivatives that may have improved efficacy and safety profiles. Additionally, alternative therapies and combination treatments are being explored to enhance the effectiveness of existing antibiotics and reduce the likelihood of resistance.In conclusion, quinolone (喹诺酮) antibiotics represent a vital tool in modern medicine for combating bacterial infections. Their unique mechanism of action and broad-spectrum activity have made them invaluable in treating a variety of infections. However, the challenges associated with their use, including side effects and the risk of resistance, underscore the need for responsible prescribing practices and ongoing research. As we continue to navigate the complexities of antibiotic therapy, understanding the role of quinolone (喹诺酮) antibiotics will remain crucial in ensuring effective treatment options for bacterial infections in the future.

喹诺酮是一类合成抗生素，广泛用于治疗各种细菌感染。这些化合物的特点是它们的双环结构，其中包括喹啉部分。第一个喹诺酮——纳利啶酸的发现标志着抗生素治疗新纪元的开始。自那时以来，开发了许多衍生物，扩大了可以有效治疗的细菌感染范围。quinolone（喹诺酮）抗生素的作用机制涉及对细菌DNA旋转酶和拓扑异构酶IV的抑制，这些酶对于DNA复制和转录至关重要。这一机制导致细菌生长受到干扰，最终导致细胞死亡。quinolone（喹诺酮）抗生素的一大显著优势是其广谱活性，这意味着它们可以靶向多种革兰氏阳性和革兰氏阴性细菌。这使得它们在治疗对其他类抗生素耐药的感染时特别有用。例如，氟喹诺酮作为quinolone（喹诺酮）的一种亚类，如环丙沙星和左氧氟沙星，通常被开用于尿路感染、呼吸道感染甚至某些皮肤感染。尽管它们有效，但使用quinolone（喹诺酮）抗生素引发了对副作用和抗生素耐药性潜在问题的担忧。一些患者可能会经历不良反应，如胃肠道紊乱、中枢神经系统效应和肌腱损伤。此外，这些抗生素的过度使用和误用导致耐药细菌株的出现，使得以前容易管理的感染变得越来越具挑战性。为了减轻这些问题，医疗提供者被鼓励谨慎开具quinolone（喹诺酮）抗生素，并仅在必要时使用。患者遵循处方治疗方案也至关重要，以确保彻底消除感染并最小化耐药风险。研究正在进行中，以开发新的quinolone（喹诺酮）衍生物，这些衍生物可能具有更好的疗效和安全性。此外，还在探索替代疗法和联合治疗，以增强现有抗生素的有效性并减少耐药的可能性。总之，quinolone（喹诺酮）抗生素代表了现代医学中对抗细菌感染的重要工具。它们独特的作用机制和广谱活性使它们在治疗各种感染方面不可或缺。然而，使用这些抗生素所面临的挑战，包括副作用和耐药风险，强调了负责任的处方实践和持续研究的必要性。在我们继续应对抗生素治疗的复杂性时，理解quinolone（喹诺酮）抗生素的作用将是确保未来细菌感染有效治疗选择的重要因素。