run-in period

简明释义

试车周期

英英释义

例句

1.After the run-in period, participants were more accustomed to the new exercise regimen.

在适应期之后，参与者对新的锻炼方案更加适应。

2.The study included a run-in period to allow participants to adjust to the treatment.

该研究包括一个适应期，以允许参与者适应治疗。

3.It's important to establish a proper run-in period in clinical trials to ensure reliable results.

在临床试验中建立一个适当的适应期是确保可靠结果的重要因素。

4.During the run-in period, we will monitor the participants closely to gather initial data.

在适应期期间，我们将密切监测参与者以收集初步数据。

5.The medication requires a run-in period of two weeks to assess its effectiveness.

该药物需要一个为期两周的适应期来评估其有效性。

作文

In the realm of scientific research and clinical trials, the term run-in period refers to a specific phase that occurs before the actual study begins. This phase is crucial for ensuring that participants are adequately prepared and meet the necessary criteria for the trial. During the run-in period, researchers often provide participants with a placebo or an initial treatment to gauge their adherence and response. This process helps to eliminate any potential biases and allows for a more accurate assessment of the treatment's effectiveness once the trial officially starts. The importance of the run-in period cannot be overstated. It serves multiple purposes, including the screening of participants, the stabilization of their conditions, and the reduction of variability in the results. By ensuring that all participants have similar baseline characteristics, researchers can draw more reliable conclusions from the data collected during the main study. For instance, if a clinical trial is testing a new medication for hypertension, the run-in period may involve adjusting participants' current medications to achieve a uniform starting point. Moreover, the run-in period can help identify participants who may not adhere to the study protocol. This is particularly important in long-term studies where consistent participation is critical. If individuals drop out during the run-in period, it is better for the integrity of the study, as it reduces the likelihood of skewed results later on. In addition to its practical applications, the run-in period also has implications for the ethical conduct of research. By ensuring that participants are fully informed and engaged, researchers uphold the principles of respect and beneficence. Participants who understand what is expected of them during this phase are more likely to give informed consent and remain committed to the study. To illustrate the significance of the run-in period, consider a recent clinical trial aimed at evaluating a new antidepressant. Researchers implemented a run-in period of six weeks, during which participants received a placebo. This allowed the team to monitor participants' mood and behavior, ensuring that those who entered the main trial were experiencing stable symptoms. Consequently, the results obtained from the trial were more robust and reflective of the medication's true efficacy. In conclusion, the run-in period is a vital component of research design, particularly in clinical trials. It enhances the reliability of results, improves participant adherence, and contributes to the ethical standards of research. Understanding the role of the run-in period can help both researchers and participants appreciate the complexities involved in scientific studies. As we continue to advance in medical research, recognizing the value of such preparatory phases will be essential for achieving meaningful outcomes and improving patient care.

在科学研究和临床试验领域，术语run-in period指的是在实际研究开始之前发生的特定阶段。这个阶段对于确保参与者充分准备并符合试验的必要标准至关重要。在run-in period期间，研究人员通常会向参与者提供安慰剂或初始治疗，以评估他们的依从性和反应。这个过程有助于消除潜在的偏见，并允许在试验正式开始后对治疗效果进行更准确的评估。run-in period的重要性不容小觑。它具有多重目的，包括筛选参与者、稳定他们的病情以及减少结果中的变异性。通过确保所有参与者具有相似的基线特征，研究人员可以从主要研究中收集的数据得出更可靠的结论。例如，如果一项临床试验正在测试一种新的高血压药物，run-in period可能涉及调整参与者当前的药物以实现统一的起始点。此外，run-in period还可以帮助识别可能不遵守研究方案的参与者。这在长期研究中特别重要，因为一致的参与对于研究的完整性至关重要。如果个体在run-in period期间退出，那么对于研究的完整性来说是更好的，因为这减少了后期结果偏差的可能性。除了其实际应用外，run-in period还对研究的伦理行为具有影响。通过确保参与者充分了解并参与，研究人员维护了尊重和仁慈的原则。理解在这一阶段对他们的期望的参与者更有可能给予知情同意并保持对研究的承诺。为了说明run-in period的重要性，考虑最近的一项旨在评估新抗抑郁药的临床试验。研究人员实施了为期六周的run-in period，期间参与者接受了安慰剂。这使得团队能够监测参与者的情绪和行为，确保进入主要试验的参与者症状稳定。因此，从试验中获得的结果更加稳健，反映了药物的真实疗效。总之，run-in period是研究设计，特别是在临床试验中的一个重要组成部分。它增强了结果的可靠性，提高了参与者的依从性，并有助于研究的伦理标准。理解run-in period的作用可以帮助研究人员和参与者欣赏科学研究中的复杂性。随着我们在医学研究中的不断进步，认识到此类准备阶段的价值将对实现有意义的结果和改善患者护理至关重要。