sulfonamide

简明释义

英[sʌlˈfɒnəmaɪd]美[sʌlˈfɑːnəmaɪd;sʌlˈfɑːnəmɪd]

n. 磺胺类药；磺胺剂

英英释义

单词用法

同义词

反义词

例句

1.Structure- activity relationship information revealed that 7-aryl-6- azaindole-1- sulfonamide derivatives was more potent than 7-anilino-6-azaindole-1- sulfonamide derivatives.

在结构与活性的关系资讯中显示， 7-苯基-6-氮基吲哚-1-磺胺类衍生物的活性比7-苯胺基-6-氮基吲哚-1-磺胺类衍 生物的活性好。

2.Using quantum mechanics MNDO program and molecular mechanics MMP2 program, we determined some unknown molecular mechanical parameters in sulfonamide compounds.

应用量子化学MNDO程序及分子力学MMP2程序，确定了一些未知磺酰胺类常咯啉的分子力学参数。

3.In this thesis, the synthesis of series of chiral sulfonamide ligands which were derived from L-proline is our another part of work.

本论文的另一部分工作是合成了L -脯氨酸衍生的系列手性磺酰胺配体。

4.The antibiotic and sulfonamide antithetical couplet this sickness fragrant is originally invalid.

抗生素和磺胺药对子本病荃本无效。

5.TLC method was established for the separation of taurolidine and related substances 2-aminoethyl sulfonyl chloride, 2-aminoethyl sulfonyl azide and 2-aminoethyl sulfonamide.

建立了TLC法分离碱性药物牛磺罗定及有关物质2-氨基乙磺酰氯、2-氨基乙磺酰叠氮和2-氨基乙磺酰胺。

6.The bacteria harmed primarily the fish' s liver and kidney and were sensitive to some antibiotics, for example, erythromycinum, compound sulfonamide and cefoperazone.

病理学观察表明该菌株主要引起高体革（鱼刺）的肝肾病变，药敏试验表明该菌株对红霉素、复合磺胺、头孢哌酮等多种抗生素敏感。

7.Warnings: PABA should not be taken when using sulfonamide (sulfa) drugs.

警告：如果你正在服用硫安类药剂，请不要同时服用PABA。

8.Structure- activity relationship information revealed that 7-aryl-6- azaindole-1- sulfonamide derivatives was more potent than 7-anilino-6-azaindole-1- sulfonamide derivatives.

在结构与活性的关系资讯中显示， 7-苯基-6-氮基吲哚-1-磺胺类衍生物的活性比7-苯胺基-6-氮基吲哚-1-磺胺类衍 生物的活性好。

9.Some patients may experience allergic reactions to sulfonamide medications.

一些患者可能会对磺胺药产生过敏反应。

10.In veterinary medicine, sulfonamide is often used to treat infections in animals.

在兽医学中，磺胺药常用于治疗动物感染。

11.The doctor prescribed a course of sulfonamide for the patient's bacterial infection.

医生为病人的细菌感染开了一疗程的磺胺药。

12.Historically, sulfonamide was one of the first antibiotics used in medicine.

历史上，磺胺药是医学中使用的第一种抗生素之一。

13.Patients should inform their doctors if they have a history of sulfonamide allergy.

患者应该告知医生他们是否有磺胺药过敏的历史。

作文

sulfonamide is a term that refers to a group of synthetic antimicrobial agents that contain a sulfonamide group. These compounds have played a crucial role in the development of modern medicine, particularly in the treatment of bacterial infections. The discovery of sulfonamide drugs in the 1930s marked a significant breakthrough in pharmacology, as they were among the first antibiotics used to combat infections effectively. Before the advent of sulfonamide drugs, bacterial infections often led to severe complications and high mortality rates. The introduction of these drugs revolutionized the way infections were treated and significantly reduced the number of fatalities associated with them.The mechanism of action of sulfonamide drugs involves the inhibition of bacterial growth by interfering with the synthesis of folic acid, which is essential for bacterial reproduction. Folic acid is produced by bacteria through a process that requires para-aminobenzoic acid (PABA). Sulfonamide drugs mimic PABA and competitively inhibit the enzyme dihydropteroate synthase, which is necessary for the production of folic acid. This inhibition leads to a decrease in the growth and proliferation of bacteria, allowing the body's immune system to eliminate the infection more effectively.One of the most notable sulfonamide drugs is sulfamethoxazole, which is often used in combination with trimethoprim to enhance its efficacy. This combination, known as co-trimoxazole, is widely prescribed for various infections, including urinary tract infections, respiratory infections, and certain types of pneumonia. The synergistic effect of these two drugs makes them a powerful tool in the fight against bacterial infections.Despite their effectiveness, the use of sulfonamide drugs is not without challenges. Over time, many bacteria have developed resistance to these antibiotics, leading to treatment failures in some cases. This resistance is often attributed to the overuse and misuse of antibiotics, which has become a growing concern in the medical community. As a result, healthcare professionals are increasingly cautious about prescribing sulfonamide drugs and are looking for alternative treatment options when necessary.In addition to their antibacterial properties, sulfonamide compounds have also been studied for other potential therapeutic applications. For instance, some sulfonamide derivatives have shown promise in the treatment of certain types of cancer, as they can inhibit cellular proliferation and induce apoptosis in cancer cells. This expanding understanding of sulfonamide compounds highlights their versatility and potential beyond traditional antibiotic therapy.In conclusion, sulfonamide drugs have significantly impacted the field of medicine by providing effective treatment options for bacterial infections. While challenges such as antibiotic resistance persist, ongoing research continues to explore the full potential of sulfonamide compounds in various therapeutic areas. Understanding the history, mechanism, and applications of sulfonamide drugs is essential for both medical professionals and patients alike, as it underscores the importance of responsible antibiotic use and the need for continued innovation in the fight against infectious diseases.

sulfonamide 是一个术语，指的是一类含有磺酰胺基团的合成抗菌剂。这些化合物在现代医学的发展中发挥了重要作用，特别是在细菌感染的治疗中。sulfonamide 药物的发现发生在20世纪30年代，标志着药理学的重大突破，因为它们是用于有效对抗感染的首批抗生素之一。在sulfonamide 药物问世之前，细菌感染常常导致严重并发症和高死亡率。这些药物的引入彻底改变了感染的治疗方式，并显著减少了与之相关的死亡人数。sulfonamide 药物的作用机制涉及通过干扰叶酸的合成来抑制细菌生长，而叶酸是细菌繁殖所必需的。细菌通过一个需要对氨基苯甲酸（PABA）的过程来生产叶酸。sulfonamide 药物模拟PABA，并竞争性地抑制二氢蝶酸合成酶，这种酶对于叶酸的生产是必要的。这种抑制导致细菌的生长和繁殖减少，使得身体的免疫系统能够更有效地消除感染。最著名的sulfonamide 药物之一是磺胺甲噁唑，它通常与甲氧苄啶联合使用以增强其疗效。这种组合，被称为复方磺胺甲噁唑，被广泛开处方用于各种感染，包括尿路感染、呼吸道感染和某些类型的肺炎。这两种药物的协同作用使它们成为对抗细菌感染的强大工具。尽管sulfonamide 药物有效，但它们的使用并非没有挑战。随着时间的推移，许多细菌已对这些抗生素产生了抗药性，导致某些情况下治疗失败。这种抗药性通常归因于抗生素的过度使用和误用，这在医学界已成为一个日益严重的问题。因此，医疗专业人员在开处方sulfonamide 药物时越来越谨慎，并在必要时寻找替代治疗方案。除了抗菌特性外，sulfonamide 化合物还被研究用于其他潜在的治疗应用。例如，一些sulfonamide 衍生物在某些类型癌症的治疗中显示出希望，因为它们可以抑制细胞增殖并诱导癌细胞凋亡。这种对sulfonamide 化合物的不断理解突显了它们的多功能性及其在传统抗生素治疗之外的潜力。总之，sulfonamide 药物通过提供有效的细菌感染治疗选择，对医学领域产生了重大影响。尽管抗生素抗药性等挑战依然存在，但持续的研究仍在探索sulfonamide 化合物在各个治疗领域的全部潜力。了解sulfonamide 药物的历史、机制和应用，对于医疗专业人员和患者来说都是至关重要的，因为这强调了负责任使用抗生素的重要性以及在对抗传染病方面继续创新的必要性。