intrathecal

简明释义

英[ˌɪntrəˈθiːk(ə)l]美[ˌɪntrəˈθiːkl]

adj. 囊内的

英英释义

单词用法

同义词

反义词

例句

1.No patient has been given an iron chelator via a continuous intrathecal infusion, which might be more effective.

尽管连续鞘内注射铁鏊合剂可能更有效，但尚未见有病人经此方法治疗。

2.Methods: Intrathecal chemotherapy was applied in 16 patients with leukemia.

方法：鞘内化疗应用于16例白血病患者。

3.Objective To summarize the effectiveness of treatment of traumatic subarachnoid hemorrhage with CSF replacement and intrathecal injection.

目的探讨脑脊液置换并鞘内注射给药在创伤性蛛网膜下腔出血治疗中的价值。

4.The study also demonstrated that intrathecal BAM8-22 inhibited nocifensive behavior in the second phase of the formalin test.

实验结果还显示椎管内注射BAM8-22也抑制大鼠福尔马林反应中的疼痛行为。

5.To evaluate the clinical efficacy and safety of intrathecal Amikacin in the treatment of intracranial infection.

目的研究阿米卡星鞘注治疗开颅术后颅内感染的临床疗效与安全性。

6.Objective To evaluate the reasons for intrathecal administration of vincristine, the characteristics of patients with nerve damage, and the effective rescue measures and outcome prognosis.

目的评价误行鞘内注射长春新碱事件的发生原因、患者神经损害的特点、抢救措施和预后。

7.The beneficial effect of intrathecal, but not oral baclofen, in our patient suggests a dose-dependent effect.

该病人硬膜内而非口服巴氯芬的良好效果表明存在剂量依赖效应。

8.Time Course and Role of Morphine Dose and Concentration in Intrathecal Granuloma Formation in Dogs: A Combined Magnetic Resonance Imaging and Histopathology Investigation.

狗鞘内肉牙肿形成后吗啡剂量和浓度相关的时间梯度与作用：一项联合磁共振和组织病理学的研究。

9.Treatment group treated with interferon intrathecal injection except for routine treatment. Then we devided the treatment group to big dose interferon group and little dose group .

治疗组除在常规治疗基础上鞘内注射干扰素外，还按干扰素注射的剂量分为大剂量组与小剂量组。

10.After the intrathecal 脊髓腔内 administration of chemotherapy, the patient experienced fewer side effects.

在进行脊髓腔内化疗后，患者经历了更少的副作用。

11.The doctor recommended an intrathecal 脊髓腔内 injection to manage the patient's chronic pain.

医生建议进行一次脊髓腔内注射来管理患者的慢性疼痛。

12.The nurse explained the procedure for the intrathecal 脊髓腔内 drug delivery system.

护士解释了脊髓腔内药物输送系统的程序。

13.Patients with severe spasticity may benefit from intrathecal 脊髓腔内 baclofen therapy.

重度痉挛的患者可能会从脊髓腔内巴克洛芬治疗中受益。

14.The research focused on the effectiveness of intrathecal 脊髓腔内 morphine for pain relief.

研究集中于脊髓腔内吗啡在缓解疼痛方面的有效性。

作文

The term intrathecal refers to a method of delivering medication directly into the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord. This technique is often used for administering drugs that need to bypass the blood-brain barrier, which can prevent many medications from reaching their intended targets in the central nervous system. In recent years, the use of intrathecal therapy has gained popularity, particularly in the treatment of chronic pain, spasticity, and certain cancers. The process involves the insertion of a catheter into the spinal canal, allowing for continuous or intermittent delivery of medication. One of the primary advantages of intrathecal drug delivery is its ability to provide localized treatment with lower doses compared to systemic administration. For patients suffering from severe pain, this can mean significant relief without the extensive side effects associated with higher doses of oral or intravenous medications. For instance, opioids can be administered via intrathecal routes, allowing for effective pain management while minimizing the risk of addiction and other adverse effects. However, the intrathecal route is not without its challenges. The procedure requires careful consideration and expertise, as there are risks involved, including infection, bleeding, and potential neurological complications. Patients must be thoroughly evaluated to determine if they are suitable candidates for this type of therapy. Additionally, the long-term effects of intrathecal drug delivery are still being studied, and ongoing monitoring is essential to ensure patient safety and treatment efficacy. In addition to pain management, intrathecal delivery is also employed in the treatment of certain neurological conditions. For example, in cases of multiple sclerosis or amyotrophic lateral sclerosis (ALS), intrathecal administration of medications such as baclofen can help alleviate muscle spasticity and improve the quality of life for patients. This targeted approach can lead to better outcomes than traditional methods, highlighting the importance of advancing our understanding of intrathecal therapies. Moreover, researchers are continually exploring new drugs and combinations that can be effectively administered through the intrathecal route. Clinical trials are underway to evaluate the efficacy of various agents, including chemotherapeutic drugs for treating cancer that metastasizes to the central nervous system. The potential to deliver these agents directly to the site of action may enhance therapeutic outcomes while reducing systemic toxicity. As we move forward, it is crucial to educate both healthcare providers and patients about the benefits and risks associated with intrathecal therapy. Awareness can lead to more informed decisions regarding treatment options and ultimately improve patient care. With ongoing advancements in medical technology and research, intrathecal drug delivery is poised to become an increasingly important tool in the management of various conditions affecting the central nervous system. In conclusion, the intrathecal route offers a promising avenue for enhancing treatment efficacy, but it requires careful consideration and continued research to maximize its potential benefits.

术语intrathecal指的是将药物直接送入包围大脑和脊髓的脑脊液（CSF）中的一种给药方法。这种技术通常用于需要绕过血脑屏障的药物，这些药物可能会阻止许多药物到达中枢神经系统的目标。近年来，intrathecal治疗在慢性疼痛、痉挛和某些癌症的治疗中越来越受到欢迎。该过程涉及将导管插入脊髓腔，从而实现药物的持续或间歇性输送。intrathecal药物输送的主要优点之一是能够提供局部治疗，而与系统给药相比使用更低剂量。对于严重疼痛的患者来说，这意味着可以显著缓解疼痛，而不必承担与口服或静脉注射药物高剂量相关的广泛副作用。例如，可以通过intrathecal途径给药阿片类药物，从而实现有效的疼痛管理，同时最小化成瘾和其他不良反应的风险。然而，intrathecal途径并非没有挑战。该过程需要仔细考虑和专业知识，因为存在感染、出血和潜在神经并发症等风险。必须对患者进行全面评估，以确定他们是否适合这种类型的治疗。此外，intrathecal药物输送的长期效果仍在研究中，持续监测对于确保患者安全和治疗有效性至关重要。除了疼痛管理，intrathecal给药也用于某些神经系统疾病的治疗。例如，在多发性硬化症或肌萎缩侧索硬化症（ALS）的病例中，intrathecal给药如巴氯芬可以帮助缓解肌肉痉挛，提高患者的生活质量。这种针对性的方法可以比传统方法带来更好的结果，突显了推进我们对intrathecal疗法理解的重要性。此外，研究人员正在不断探索可以通过intrathecal途径有效给药的新药物和组合。临床试验正在进行中，以评估各种药物的疗效，包括用于治疗转移到中枢神经系统的癌症的化疗药物。直接将这些药物送到作用部位的潜力可能增强治疗效果，同时减少全身毒性。随着我们向前发展，教育医疗提供者和患者了解与intrathecal治疗相关的益处和风险至关重要。提高意识可以导致有关治疗选择的更明智决定，最终改善患者护理。随着医疗技术和研究的不断进步，intrathecal药物输送有望成为管理影响中枢神经系统的各种疾病的重要工具。总之，intrathecal途径为提高治疗效果提供了一个有前途的途径，但需要仔细考虑和持续研究以最大化其潜在益处。