antisense

简明释义

英[ˈæntɪsens]美[ˈæntiˌsens]

adj. 反义的；反意念的；反本性的

英英释义

单词用法

同义词

反义词

例句

1.Thus, it is possible to significantly suppress nonsense mutations within target genes using antisense PNAs.

由此可见，反义pna有可能在靶基因区域显著性抑制无义突变。

2.Objective: To investigate the growth inhibition of antisense oligonucleotides of telomerase on liver tumor cell enhanced by albumin nanoparticles.

目的：利用纳米载体增强端粒酶反义寡核苷酸对肝脏肿瘤细胞生长的抑制作用。

3.The first antisense RNAs' naturally occurring were identified in plasmids and other prokaryotic accessory DNA elements.

反义RNA的存在最先是在质粒和其它原核附属DNA元件中被证实的。

4.Antisense Morpholino oligos have shown promise in preclinical studies however, they were found to cause a limited viral load reduction.

反义的吗啉寡展示了临诊前期的研究的前景，然而，它们被发现能引起一个有限的病毒载量减少。

5.Objective to construct eukaryotic expression vector of antisense MBD1 gene fragment and to provide a tool for studying MBD1 gene function.

目的构建反义MBD1基因片段真核表达载体，为研究MBD1基因功能提供工具。

6.Objective To study the effects of antisense oligodeoxynucleotide(AS/TF) for rat tissue factor (TF) on the myocardial ischemic reperfusion injury.

目的：研究组织因子（TF）反义寡脱氧核苷酸（AS/TF）对大鼠心肌缺血再灌注损伤的作用。

7.Objective: To study the antisense oligonucleotide mediated inhibition on telomerase activity and cell proliferation of GBC-SD cell.

目的：探讨反义寡核苷酸对胆囊癌细胞端粒酶活性的影响及对胆囊癌细胞生长增殖的作用。

8.Objective: to screen the high performance, specific and nontoxic anti HBV antisense oligonucleotide fragment.

目的：筛选出高效特异而无毒的抗hbv反义寡核苷酸片段。

9.Conclusions: The growth of tumor can be inhibited significantly by antisense-VEGF gene transfection.

结论反义vegf基因转染可以有效地抑制喉癌的生长。

10.The company patented a new antisense 反义 compound that shows promise in clinical trials.

该公司获得了一种新反义化合物的专利，该化合物在临床试验中显示出希望。

11.The research team developed an antisense 反义 oligonucleotide to inhibit the expression of a specific gene.

研究小组开发了一种反义寡核苷酸，以抑制特定基因的表达。

12.In cancer therapy, antisense 反义 technology can be used to target and silence oncogenes.

在癌症治疗中，反义技术可以用来靶向和沉默癌基因。

13.The antisense 反义 RNA was introduced to block the production of a harmful protein.

引入了反义RNA以阻止有害蛋白的产生。

14.Scientists are exploring antisense 反义 approaches for treating genetic disorders.

科学家们正在探索使用反义方法治疗遗传疾病。

作文

In recent years, the field of molecular biology has witnessed significant advancements, particularly in the area of gene expression regulation. One of the most intriguing concepts that have emerged is the idea of antisense technology. This innovative approach involves the use of antisense oligonucleotides, which are short strands of DNA or RNA designed to bind to specific mRNA molecules. By doing so, they can effectively inhibit the production of proteins associated with various diseases. The potential applications of antisense technology are vast, ranging from cancer treatment to genetic disorders. The mechanism behind antisense technology is relatively straightforward. When a antisense oligonucleotide binds to its complementary mRNA strand, it prevents the ribosome from translating that mRNA into protein. This process is crucial because many diseases are caused by the overexpression of certain proteins. For instance, in cancer cells, specific oncogenes may be abnormally activated, leading to uncontrolled cell growth. By applying antisense oligonucleotides targeted at these oncogenes, researchers can potentially reduce the levels of the corresponding proteins and slow down or even stop tumor progression.Furthermore, antisense technology is not limited to cancer treatment alone. It has also shown promise in addressing genetic disorders caused by mutations in specific genes. For example, spinal muscular atrophy (SMA) is a genetic disease characterized by the loss of motor neurons, leading to muscle weakness and atrophy. Researchers have developed antisense therapies that target the faulty gene responsible for SMA, allowing for the production of a functional protein that can ameliorate the symptoms of the disease.Despite its potential, antisense technology is not without challenges. One major hurdle is the delivery of antisense oligonucleotides to the target cells. The oligonucleotides must be able to enter the cells and reach the cytoplasm where the mRNA resides. Various delivery methods are being explored, including lipid nanoparticles and viral vectors, to enhance the efficacy of antisense therapies.Moreover, the specificity of antisense oligonucleotides is crucial. Off-target effects can lead to unintended consequences, such as the silencing of non-target genes, which may result in adverse side effects. Therefore, researchers are working diligently to improve the design of antisense molecules to ensure their precision and minimize any potential risks.In conclusion, antisense technology represents a groundbreaking approach in the realm of molecular medicine. Its ability to selectively inhibit gene expression opens new avenues for treating a variety of diseases, particularly those with a genetic basis. As research continues to evolve, we may witness the emergence of more effective antisense therapies that could revolutionize the way we approach disease management. The future of antisense technology is promising, offering hope to countless individuals affected by debilitating conditions.

近年来，分子生物学领域见证了显著的进展，尤其是在基因表达调控方面。一个引人入胜的概念是antisense技术。这种创新的方法涉及使用antisense寡核苷酸，这是一种短链DNA或RNA，旨在与特定的mRNA分子结合。通过这样做，它们可以有效地抑制与各种疾病相关的蛋白质的产生。antisense技术的潜在应用广泛，从癌症治疗到遗传疾病。antisense技术背后的机制相对简单。当antisense寡核苷酸与其互补的mRNA链结合时，它会阻止核糖体将该mRNA翻译成蛋白质。这个过程至关重要，因为许多疾病是由某些蛋白质的过度表达引起的。例如，在癌细胞中，特定的癌基因可能异常激活，导致细胞不受控制地生长。通过应用针对这些癌基因的antisense寡核苷酸，研究人员有可能减少相应蛋白质的水平，从而减缓甚至停止肿瘤进展。此外，antisense技术不仅限于癌症治疗。它在应对由特定基因突变引起的遗传疾病方面也显示出希望。例如，脊髓性肌萎缩症（SMA）是一种遗传疾病，其特征是运动神经元的丧失，导致肌肉无力和萎缩。研究人员开发了针对导致SMA的缺陷基因的antisense疗法，允许产生一种功能性蛋白质，从而改善疾病的症状。尽管有潜力，antisense技术并非没有挑战。一个主要障碍是将antisense寡核苷酸传递到目标细胞。寡核苷酸必须能够进入细胞并到达mRNA所在的细胞质。各种递送方法正在被探索，包括脂质纳米颗粒和病毒载体，以增强antisense疗法的有效性。此外，antisense寡核苷酸的特异性至关重要。非靶向效应可能导致意外后果，例如非靶向基因的沉默，这可能导致不良副作用。因此，研究人员正在努力改进antisense分子的设计，以确保其精确性并最小化任何潜在风险。总之，antisense技术代表了分子医学领域的一种突破性方法。其选择性抑制基因表达的能力为治疗各种疾病，特别是那些具有遗传基础的疾病开辟了新的途径。随着研究的不断发展，我们可能会见证更多有效的antisense疗法的出现，这可能彻底改变我们对疾病管理的方式。antisense技术的未来充满希望，为无数受困扰的个体提供了希望。