uncoupler

简明释义

英[ʌnˈkʌplər]美[ʌnˈkʌplər]

n. [生化] 解偶联剂；[生化] 解联剂

英英释义

单词用法

同义词

反义词

例句

1.The utility model relates to an automatic uncoupler brake hook device for fishing.

本实用新型涉及钓鱼自动起杆刹钩器。

2.It is proved that the addition of TCP as a metabolic uncoupler into activated sludge can reduce the yield of excess sludge.

应用TCP作为代谢解偶联剂投加到活性污泥工艺中可减少剩余污泥的产量。

3.It is proved that the addition of TCP as a metabolic uncoupler into activated sludge can reduce the yield of excess sludge.

应用TCP作为代谢解偶联剂投加到活性污泥工艺中可减少剩余污泥的产量。

4.The engineer used an uncoupler to separate the two train cars for maintenance.

工程师使用了一个解耦器来分离两个火车车厢以进行维护。

5.The team installed an uncoupler in the pipeline to allow for easier repairs.

团队在管道中安装了一个解耦器以便于修理。

6.In the chemical process, the uncoupler was essential for preventing unwanted reactions.

在化学过程中，解耦器对于防止不必要的反应至关重要。

7.Using an uncoupler can improve the efficiency of the electrical system.

使用解耦器可以提高电气系统的效率。

8.During the experiment, the uncoupler helped to isolate the variables effectively.

在实验过程中，解耦器有效地帮助隔离了变量。

作文

In the realm of biochemistry, the term uncoupler refers to a substance that disrupts the coupling between electron transport and ATP synthesis in mitochondria. This process is essential for cellular respiration, where energy derived from nutrients is converted into adenosine triphosphate (ATP), the energy currency of the cell. When an uncoupler is introduced into the mitochondria, it allows protons to flow back into the mitochondrial matrix without passing through ATP synthase. As a result, the energy generated from the electron transport chain is released as heat rather than being used to produce ATP.This phenomenon can be likened to a car running on gasoline but instead of converting that fuel into motion, it simply burns off the energy as heat. The implications of using uncouplers are significant in various fields, especially in understanding metabolic processes and developing therapeutic strategies for obesity and diabetes. For instance, the well-known compound 2,4-dinitrophenol (DNP) acts as a powerful uncoupler. It was historically used as a weight-loss drug because it increases metabolic rate by causing the body to burn more calories. However, its use was discontinued due to severe side effects, including hyperthermia and even death.The study of uncouplers extends beyond just their role in metabolism; they also provide insights into the efficiency of energy production in cells. By examining how uncouplers affect ATP synthesis, researchers can better understand the mechanisms of mitochondrial function and dysfunction. Mitochondrial diseases, which arise from defects in the mitochondrial DNA or nuclear genes, can lead to a variety of health issues. Understanding how uncouplers operate may pave the way for novel treatments that enhance mitochondrial function or mitigate the effects of these diseases.Furthermore, uncouplers have garnered attention in the context of aging research. Some studies suggest that mild uncoupling could promote longevity by reducing oxidative stress and improving metabolic flexibility. This has led scientists to explore the potential of developing safe and effective uncouplers that can mimic these beneficial effects without the associated risks of compounds like DNP.In conclusion, the concept of uncoupler is not merely a technical term confined to textbooks; it embodies a critical aspect of cellular metabolism with broad implications for health and disease. As research continues to unravel the complexities of mitochondrial function, the role of uncouplers will undoubtedly remain a focal point in the quest to enhance human health and combat metabolic disorders. Through a deeper understanding of these fascinating molecules, we can harness their potential to improve our lives, making the study of uncouplers a pivotal area in modern scientific exploration.

在生物化学领域，术语uncoupler指的是一种物质，它破坏了线粒体中电子传递与ATP合成之间的耦合。这个过程是细胞呼吸所必需的，在这个过程中，从营养物质中获得的能量被转化为三磷酸腺苷（ATP），即细胞的能量货币。当uncoupler被引入线粒体时，它允许质子在不经过ATP合酶的情况下流回线粒体基质。因此，来自电子传递链的能量以热量的形式释放，而不是用于生成ATP。这种现象可以比作一辆汽车使用汽油，但不是将燃料转化为运动，而是简单地将能量燃烧掉作为热量。使用uncouplers的影响在各个领域都具有重要意义，尤其是在理解代谢过程和开发治疗肥胖和糖尿病的策略方面。例如，著名的化合物2,4-二硝基苯酚（DNP）作为一种强效的uncoupler。它曾被用作减肥药，因为它通过使身体消耗更多卡路里来提高代谢率。然而，由于严重的副作用，包括高热甚至死亡，其使用已被停止。对uncouplers的研究不仅仅局限于它们在代谢中的角色；它们还提供了对细胞能量生产效率的深入了解。通过检查uncouplers如何影响ATP合成，研究人员可以更好地理解线粒体功能和功能失调的机制。线粒体疾病源于线粒体DNA或核基因的缺陷，可能导致各种健康问题。理解uncouplers如何运作可能为增强线粒体功能或减轻这些疾病影响的新疗法铺平道路。此外，uncouplers在衰老研究中也引起了关注。一些研究表明，温和的解耦可能通过减少氧化压力和改善代谢灵活性来促进长寿。这促使科学家探索开发安全有效的uncouplers的潜力，以模仿这些有益的效果，而不会带来像DNP这样的化合物相关的风险。总之，uncoupler的概念不仅仅是一个局限于教科书的技术术语；它体现了细胞代谢的一个关键方面，对健康和疾病具有广泛的影响。随着研究继续揭示线粒体功能的复杂性，uncouplers的角色无疑将继续成为增强人类健康和对抗代谢障碍的关键点。通过对这些迷人分子的深入理解，我们可以利用它们的潜力来改善我们的生活，使uncouplers的研究成为现代科学探索中的一个重要领域。