proteoglycan

简明释义

英[ˌprəʊtɪəʊˈɡlaɪkæn]美[ˌproʊtɪoʊˈɡlaɪkæn]

n. 蛋白多糖；[生化] 蛋白聚糖

英英释义

单词用法

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例句

1.Objective To study the association of particulate brain proteoglycan (PG) with development and aging of the brain.

目的探讨颗粒性脑蛋白聚糖（PG）与脑发育和老化的关系。

2.The chains might be side chains of proteoglycan.

这种物质可能是蛋白多糖的侧链。

3.CD44 is a highly heterogeneity family of cell surface proteoglycan, represent products of a single gene and widely expressing in various tissues.

CD44是单一基因所编码的具有高度异质性的单链膜表面糖蛋白家族，在各种组织中广泛表达。

4.Staining for agrin, the major HS proteoglycan core protein in the GBM, was unaltered.

而GBM内主要的HS蛋白多糖核心蛋白—集聚蛋白（Agrin）染色没有变化。

5.Articular cartilage, which is composed with a solid phase of collagen fibers and proteoglycan and a pore fluid phase, can be depicted with two-phase porous medium model based on mixture theory.

关节软骨为一由骨胶原和蛋白聚糖固体相和孔隙流体相组成的多孔材料，其可以用基于混合物理论的两相多孔介质模型准确描述。

6.The remarkable changes of contact stress of patellofemoral joint, the cartilaginous degeneration, and matrix proteoglycan loss not found in the lateral cartilaginous side of patella.

而髌骨外侧面软骨接触压力无明显改变，软骨变性不明显，蛋白多糖含量无明显减少。

7.Objective To observe the effects of ectogenetic estrogen on changes of proteoglycan (PG) in articular cartilage matrix of osteoarthritis(OA) and to explore the treatment of ectogenetic estrogen on OA.

目的观察雌激素对骨关节炎（OA） 模型软骨基质蛋白多糖变化的影响，探讨外源性雌激素治疗OA的作用机理。

8.Certain diseases can lead to the degradation of proteoglycan 蛋白聚糖 in tissues, affecting their function.

某些疾病会导致组织中蛋白聚糖 proteoglycan 的降解，从而影响其功能。

9.Scientists are exploring the use of proteoglycan 蛋白聚糖 in regenerative medicine for tissue repair.

科学家们正在探索在再生医学中使用蛋白聚糖 proteoglycan 来进行组织修复。

10.The structure of cartilage is largely composed of proteoglycan 蛋白聚糖, which provides cushioning and support.

软骨的结构主要由蛋白聚糖 proteoglycan 组成，提供缓冲和支持。

11.In joint health, the presence of proteoglycan 蛋白聚糖 helps to retain water and maintain lubrication.

在关节健康中，蛋白聚糖 proteoglycan 的存在有助于保持水分和维持润滑。

12.Research has shown that proteoglycan 蛋白聚糖 plays a crucial role in cell signaling.

研究表明，蛋白聚糖 proteoglycan 在细胞信号传递中起着至关重要的作用。

作文

Proteoglycans are complex molecules that play a crucial role in the structure and function of various tissues in the body. These molecules are composed of a core protein to which glycosaminoglycan (GAG) chains are attached, making them highly hydrophilic and capable of retaining large amounts of water. This unique property allows proteoglycans (蛋白聚糖) to provide structural support in connective tissues, such as cartilage, tendons, and ligaments. In addition to their structural role, proteoglycans (蛋白聚糖) are involved in cell signaling, influencing cellular functions such as growth, migration, and differentiation.One of the most well-known proteoglycans (蛋白聚糖) is aggrecan, which is predominantly found in cartilage. Aggrecan binds to hyaluronic acid to form large aggregates that contribute to the resilience and compressive strength of cartilage. This is particularly important in joints, where the ability to withstand mechanical stress is essential for mobility and overall joint health. The loss or degradation of proteoglycans (蛋白聚糖) in cartilage is associated with conditions such as osteoarthritis, leading to pain and reduced function.In addition to their role in cartilage, proteoglycans (蛋白聚糖) are also found in other tissues, including skin, blood vessels, and the extracellular matrix. They contribute to the structural integrity of these tissues and help regulate various biological processes. For instance, proteoglycans (蛋白聚糖) interact with growth factors and cytokines, modulating their availability and activity. This interaction is vital for wound healing, tissue repair, and inflammation responses.Moreover, proteoglycans (蛋白聚糖) have been implicated in several diseases. Abnormal expression or modification of proteoglycans (蛋白聚糖) can lead to pathological conditions, including cancer, where they may affect tumor growth and metastasis. Research has shown that certain proteoglycans (蛋白聚糖) can promote or inhibit cancer cell proliferation, highlighting their potential as therapeutic targets.The study of proteoglycans (蛋白聚糖) is an evolving field, with ongoing research aimed at understanding their diverse functions and mechanisms of action. Advances in biotechnology and molecular biology have enabled scientists to investigate the roles of specific proteoglycans (蛋白聚糖) in greater detail. For example, techniques such as mass spectrometry and gene editing allow researchers to analyze proteoglycans (蛋白聚糖) at the molecular level, providing insights into their structure-function relationships.In conclusion, proteoglycans (蛋白聚糖) are essential components of the extracellular matrix that contribute significantly to the structural and functional properties of various tissues. Their ability to retain water, interact with other biomolecules, and participate in cell signaling underscores their importance in maintaining tissue homeostasis and responding to injury. Understanding the role of proteoglycans (蛋白聚糖) in health and disease may pave the way for novel therapeutic strategies in regenerative medicine and oncology.