acetylate

简明释义

英[əˈsetɪˌleɪt]美[əˈsetˌleɪt]

v. 加乙酰基于（分子，化合物）；把乙酸基加进（化合物）

第 三 人 称 单 数 a c e t y l a t e s

现 在 分 词 a c e t y l a t i n g

过 去 式 a c e t y l a t e d

过 去 分 词 a c e t y l a t e d

英英释义

单词用法

同义词

反义词

例句

1.The reaction proceeds at room temperature and the quality and yield of acetylate are comparison with ordinary method.

反应在常温下进行，乙酰化产物的产率和质量与原方法相当。

2.Study on the quantum chemical calculations is performed by means of MNDO method on VAX8350 computer for rubescensine A and its acetylate derivative.

本文用MNDO方法在VAX8350计算机上对冬凌草甲素及其乙酰衍生物进行了量子化学计算研究。

3.Study on the quantum chemical calculations is performed by means of MNDO method on VAX8350 computer for rubescensine A and its acetylate derivative.

本文用MNDO方法在VAX8350计算机上对冬凌草甲素及其乙酰衍生物进行了量子化学计算研究。

4.The team found that acetylating the drug increased its efficacy.

团队发现对药物进行乙酰化可以提高其疗效。

5.The researchers decided to acetylate the compound to enhance its solubility.

研究人员决定乙酰化该化合物以提高其溶解度。

6.To improve the flavor profile, they acetylated the food additive.

为了改善风味，他们对食品添加剂进行了乙酰化处理。

7.They used a chemical reaction to acetylate the alcohol, resulting in a new product.

他们通过化学反应对醇进行乙酰化，得到了新产品。

8.In order to study the enzyme's activity, scientists often acetylate specific substrates.

为了研究酶的活性，科学家们经常对特定底物进行乙酰化。

作文

The process of chemical modification is essential in many fields, particularly in biochemistry and pharmacology. One such modification is to acetylate a compound, which involves the addition of an acetyl group (CH3CO) to a molecule. This process can significantly alter the properties and functions of the original compound. For instance, when proteins are acetylated, this modification can affect their stability, activity, and interactions with other molecules. Understanding how to acetylate proteins is crucial in the development of new drugs and therapies. In the realm of enzymatic reactions, the enzyme responsible for acetylating substrates is known as an acetyltransferase. These enzymes play a vital role in various metabolic pathways. For example, the acetylation of histones, which are proteins that help package DNA in the nucleus, is a key regulatory mechanism in gene expression. When histones are acetylated, the DNA becomes more accessible for transcription, allowing genes to be expressed more readily.Moreover, the acetylation process is not limited to proteins; it also applies to small molecules and natural products. In the pharmaceutical industry, acetylating certain drugs can enhance their bioavailability or modify their pharmacokinetics. For instance, the analgesic drug aspirin is derived from salicylic acid through an acetylation reaction, which improves its effectiveness and reduces gastrointestinal irritation compared to its parent compound.In addition to its applications in medicine, acetylation is also significant in the field of polymer chemistry. Many polymers can be modified through acetylation to improve their thermal stability and mechanical properties. This is particularly important in the production of plastics and coatings that require specific characteristics to perform effectively in various environments.Despite the benefits of acetylation, it is essential to consider the potential drawbacks as well. Over-acetylation of proteins can lead to dysfunction and has been associated with various diseases, including cancer and neurodegenerative disorders. Therefore, researchers are continuously exploring the balance between necessary acetylation and its potential pathological effects. In conclusion, the ability to acetylate compounds is a powerful tool in both research and industry. By manipulating the acetylation status of a molecule, scientists can explore new avenues for drug development, improve biomolecular interactions, and enhance material properties. As our understanding of acetylation continues to grow, so too will its applications across various scientific disciplines, highlighting its importance in the advancement of technology and medicine.

化学修饰的过程在许多领域中都是至关重要的，特别是在生物化学和药理学中。其中一种修饰是对化合物进行乙酰化，这涉及将一个乙酰基（CH3CO）添加到分子上。这个过程可以显著改变原始化合物的性质和功能。例如，当蛋白质被乙酰化时，这种修饰可以影响它们的稳定性、活性以及与其他分子的相互作用。理解如何对蛋白质进行乙酰化对于新药和疗法的开发至关重要。在酶促反应的领域，负责对底物进行乙酰化的酶被称为乙酰转移酶。这些酶在各种代谢途径中发挥着重要作用。例如，组蛋白的乙酰化（组蛋白是帮助包装细胞核中DNA的蛋白质）是基因表达中的关键调控机制。当组蛋白被乙酰化时，DNA变得更易于转录，从而使基因能够更容易地表达。此外，乙酰化过程不仅限于蛋白质；它也适用于小分子和天然产物。在制药行业中，对某些药物进行乙酰化可以增强其生物利用度或改变其药代动力学。例如，镇痛药阿司匹林是通过对水杨酸进行乙酰化反应而得出的，这提高了其有效性并减少了与其母体化合物相比的胃肠刺激。除了在医学中的应用外，乙酰化在聚合物化学领域也具有重要意义。许多聚合物可以通过乙酰化进行改性，以改善其热稳定性和机械性能。这在生产需要特定特性的塑料和涂料方面尤其重要，以便在各种环境中有效地发挥作用。尽管乙酰化带来了许多好处，但考虑潜在的缺点也是必不可少的。蛋白质的过度乙酰化可能导致功能障碍，并与包括癌症和神经退行性疾病在内的各种疾病相关。因此，研究人员不断探索必要的乙酰化与其潜在病理效应之间的平衡。总之，能够对化合物进行乙酰化是一项在研究和工业中强大的工具。通过操控分子的乙酰化状态，科学家们可以探索新药开发的新途径，改善生物分子相互作用，并增强材料特性。随着我们对乙酰化的理解不断深入，它在各个科学学科中的应用也将不断增加，突显了其在技术和医学进步中的重要性。