microsomal

简明释义

英[ˌmaɪkrəˈsoʊməl]美[ˌmaɪkrəˈsoʊməl]

微粒体

微粒体的

英英释义

单词用法

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例句

1.OBJECTIVE To investigate the protective effect of Punica granatum L. on rat liver microsomal lipid peroxidation.

目的研究石榴皮提取物对大鼠肝微粒体脂质过氧化损伤的保护作用。

2.Oxidative stress after PH can not only impede hepatocellular proliferation, but also damage liver microsomal CYP450.

PH引起的氧化应激和炎症因子不仅阻碍肝细胞增殖，还可损伤肝微粒体CYP450酶。

3.An example of a flavoprotein undergoing a one-electron transfer is with the microsomal NADPH-cytochrome P450 reductase.

的一个经历一个单电子转移黄素蛋白的例子是与微粒NADPH-细胞色素P 450还原酶。

4.The effects of sodium dodecyl sulfonate (SDS) on lipid peroxidation in rat liver microsomal system has been studied.

文章报告了阳离子表面活性剂十二烷基硫酸钠(SDS)对大鼠肝微粒体脂质过氧化模型的影响。

5.The results indicate that CBD exerts toxic effect on the macrophages of rat and mouse and the toxicity may be altered by liver microsomal MFO.

这些结果表明，CBD对鼠类巨噬细胞具有毒性作用，并且可能受肝微粒体混合功能氧化酶的影响。

6.Slentrol is a new chemical entity called a selective microsomal triglyceride transfer protein inhibitor, which blocks the assembly and release of lipoproteins into the bloodstream.

Slentrol是一种新型化学物质，选择性微粒体甘油三酸酯转移蛋白抑制剂，阻断脂蛋白在血液中的合成和释放。

7.Conclusion Chronic intermittent hypoxia can increase rat liver microsomal ERD and ANH activities. The mechanism is related to up-regulation of CYP3A2 and CYP2E1 expression at the transcriptive levels.

结论慢性间断性低氧能明显增加大鼠肝脏erd (CYP3A2)和ANH (CYP2E1)活性，其机制可能与其在转录水平上提高肝脏cyp3a2和CYP2E1的基因表达水平有关。

8.The liver cells contain a significant amount of microsomal 微粒体的 enzymes that are crucial for drug metabolism.

肝细胞中含有大量的微粒体的酶，这对药物代谢至关重要。

9.Researchers found that the microsomal 微粒体的 fraction of the cells had higher activity in detoxifying harmful substances.

研究人员发现，细胞的微粒体的部分在解毒有害物质方面具有更高的活性。

10.The microsomal 微粒体的 membrane plays a key role in the transport of proteins within the cell.

微粒体的膜在细胞内蛋白质运输中发挥着关键作用。

11.The study focused on the microsomal 微粒体的 oxidation of fatty acids in human liver tissues.

该研究集中于人类肝组织中微粒体的脂肪酸氧化。

12.In pharmacology, understanding the microsomal 微粒体的 enzyme systems is essential for predicting drug interactions.

在药理学中，理解微粒体的酶系统对于预测药物相互作用至关重要。

作文

In the world of biochemistry, the term microsomal refers to the fraction of cellular components that are derived from the endoplasmic reticulum and is crucial for understanding various metabolic processes. The microsomal fraction contains a variety of enzymes that play a significant role in drug metabolism and the biotransformation of xenobiotics. These enzymes, primarily cytochrome P450 enzymes, are responsible for the oxidation of organic substances, which is essential for detoxifying harmful compounds and facilitating their excretion from the body.One of the most interesting aspects of microsomal enzymes is their adaptability. They can metabolize a wide range of substrates, including pharmaceuticals, environmental pollutants, and endogenous compounds. For instance, when a new drug is introduced into the market, researchers often conduct studies on its microsomal metabolism to predict how the body will process it. This is crucial because the efficiency and pathways of metabolism can significantly influence a drug's efficacy and safety.The study of microsomal enzymes has also led to advancements in personalized medicine. By understanding an individual's unique metabolic profile, healthcare providers can tailor drug therapies to minimize adverse effects and maximize therapeutic benefits. This personalized approach is particularly important in treating chronic diseases where patients may respond differently to the same medication due to variations in their microsomal enzyme activity.Moreover, the microsomal fraction is not only limited to human biology; it is also studied in various animal models to understand interspecies differences in drug metabolism. Such research helps in predicting how humans might react to certain drugs based on animal studies. It is fascinating to see how the microsomal systems of different species can vary significantly, affecting the pharmacokinetics and pharmacodynamics of drugs.Additionally, the role of microsomal enzymes extends beyond just drug metabolism. They are also involved in the synthesis of lipids and the metabolism of fatty acids. This connection highlights the importance of microsomal enzymes in maintaining overall cellular health and function. Dysregulation of these enzymes can lead to various diseases, including metabolic disorders and cancer. Therefore, understanding the function and regulation of microsomal enzymes is vital for developing therapeutic strategies aimed at these conditions.In conclusion, the significance of microsomal enzymes in biochemistry cannot be overstated. They are essential for drug metabolism, personalized medicine, and understanding interspecies differences in pharmacology. As research continues to uncover the complexities of microsomal functions, we can expect to see innovative approaches in drug development and disease treatment that leverage this knowledge. The exploration of microsomal systems will undoubtedly pave the way for breakthroughs in medical science, ultimately leading to improved health outcomes for individuals worldwide.

在生物化学的世界中，术语microsomal指的是源自内质网的细胞成分的分数，对于理解各种代谢过程至关重要。microsomal分数包含多种酶，这些酶在药物代谢和外源性物质的生物转化中发挥着重要作用。这些酶，主要是细胞色素P450酶，负责有机物质的氧化，这对于解毒有害化合物并促进其从体内排泄至关重要。microsomal酶的一个有趣方面是它们的适应性。它们可以代谢广泛的底物，包括药物、环境污染物和内源性化合物。例如，当一种新药上市时，研究人员通常会对其microsomal代谢进行研究，以预测身体将如何处理它。这一点至关重要，因为代谢的效率和途径可以显著影响药物的疗效和安全性。对microsomal酶的研究还推动了个性化医学的发展。通过了解个体独特的代谢特征，医疗提供者可以量身定制药物治疗，以最小化不良反应并最大化治疗效果。这种个性化的方法在治疗慢性疾病时尤为重要，因为患者对相同药物的反应可能因其microsomal酶活性的差异而不同。此外，microsomal分数不仅限于人类生物学；它也在各种动物模型中进行研究，以了解物种间药物代谢的差异。这种研究有助于预测人类对某些药物的反应，基于动物研究。看到不同物种的microsomal系统可能存在显著差异，影响药物的药代动力学和药效动力学，真是令人着迷。此外，microsomal酶的作用不仅限于药物代谢。它们还参与脂质的合成和脂肪酸的代谢。这一联系突显了microsomal酶在维持整体细胞健康和功能方面的重要性。这些酶的失调可能导致各种疾病，包括代谢紊乱和癌症。因此，理解microsomal酶的功能和调节对于开发针对这些疾病的治疗策略至关重要。总之，microsomal酶在生物化学中的重要性不容小觑。它们对于药物代谢、个性化医学以及理解药理学中的物种间差异至关重要。随着研究不断揭示microsomal功能的复杂性，我们可以期待在药物开发和疾病治疗中看到利用这一知识的创新方法。对microsomal系统的探索无疑将为医学科学的突破铺平道路，最终改善全球个体的健康结果。