sialic

简明释义

英[saɪˈælɪk]美[saɪˈælɪk]

adj. 唾液的；富硅铝的；硅铝质的

英英释义

单词用法

同义词

反义词

例句

1.The solid sialic acid was obtained by lyophilization after counteraction, filtration and separation using ion exchange chromatography.

水解液中和过滤后，用离子交换色谱分离与冷冻干燥得到唾液酸产品。

2.Some sialic acid is on the external surface of lysosomes.

有些唾液酸位于溶酶体的外表面。

3.Now, a defect in the synthesis of gangliosides, glycolipids that contain sialic acid and are abundant in the brain, has been shown to underlie an inherited form of epilepsy.

现在，有研究表明，在神经节苷脂的合成过程中起作用的糖脂缺陷或者障碍，会增加遗传性癫痫的发生几率，而这种糖脂福含唾液酸并且在大脑中的含量很多。

4.On the contrary, the L-lactate at high concentrations significantly increased the content of sialic acid and slightly decreased the site occupancy of N-linked oligosaccharides.

乳酸的作用相反，高浓度的乳酸增加了唾液酸含量，N -连接寡糖的位点占有率略有降低。

5.Objective To study the value of serum sialic acid(SA) level in diagnosis of malignancies and inflammatory diseases.

目的探讨血清唾液酸检测在恶性肿瘤及炎性疾病中的诊断价值。

6.Polymerization of fibrin monomer was inverse ratio with fibrinogen bound sialic acid. It suggests that fibrinogen boud sialic acid levels may be diagnostic index acquired dysfibrinogenaemia.

表明纤维蛋白原结合唾液酸的水平可作为诊断肝硬化获得性异常纤维蛋白血症的理想指标。

7.Objective: To establish a rapid and highly sensitive fluorescent method suitably used for clinical detection of sialic acid in serum samples.

目的：建立一种快速而灵敏的荧光分析法用于临床上血清涎酸分析测定。

8.Objective: To investigate the antiamnesic effect of pregnenolone sialic glycoside on memory impairment in mice.

目的：研究孕烯醇酮唾液酸苷对小鼠记忆障碍的改善作用。

9.The study focused on the role of sialic 唾液酸 acids in cellular interactions.

这项研究集中于<顺便>唾液酸在细胞相互作用中的作用。

10.Researchers discovered that sialic 唾液酸 residues can influence immune responses.

研究人员发现<顺便>唾液酸残基可以影响免疫反应。

11.Elevated levels of sialic 唾液酸 in blood can be indicative of certain diseases.

血液中<顺便>唾液酸水平升高可能是某些疾病的指示。

12.The presence of sialic 唾液酸 acids on the surface of pathogens helps them evade detection.

病原体表面存在的<顺便>唾液酸有助于它们逃避检测。

13.In glycoproteins, sialic 唾液酸 plays a crucial role in stability and function.

在糖蛋白中，<顺便>唾液酸在稳定性和功能中起着关键作用。

作文

In the realm of biochemistry, the term sialic refers to a family of nine-carbon sugars that are typically found at the ends of glycan chains on glycoproteins and glycolipids. These sugars play a crucial role in various biological processes, including cell signaling, immune response, and cellular recognition. The presence of sialic acids on the surface of cells can influence how cells interact with one another and with pathogens, making them a significant focus of research in immunology and cancer biology.One of the most studied types of sialic acid is N-acetylneuraminic acid (Neu5Ac), which is widely distributed in animal tissues. This particular sialic acid is involved in numerous physiological functions. For instance, it contributes to the negative charge of the cell surface, which helps to repel other negatively charged entities, such as bacteria and viruses. This property is vital for maintaining the integrity of cells and preventing infection.Moreover, sialic acids are known to be involved in the modulation of immune responses. They can act as 'self' markers on the surface of cells, helping the immune system distinguish between the body’s own cells and foreign invaders. When the sialic acid residues are removed or altered, it can signal to the immune system that the cell is damaged or infected, triggering an immune response. This has important implications for understanding autoimmune diseases and developing therapies that can manipulate these pathways.In the context of cancer, the expression of sialic acids on tumor cells can also affect their behavior. Tumor cells often exhibit altered sialic acid profiles, which can enhance their ability to evade the immune system. For example, some cancers may overexpress specific sialic acids, leading to a protective shield that inhibits immune detection and destruction. Understanding these mechanisms is crucial for developing targeted cancer therapies that can disrupt the tumor's ability to hide from the immune system.Research into sialic acids extends beyond basic biology; it has practical applications in medicine and biotechnology. For instance, the presence of sialic acids on therapeutic proteins can influence their stability, distribution, and efficacy. Biopharmaceutical companies often engineer glycosylation patterns, including sialic acid content, to optimize drug performance and reduce potential side effects.Additionally, sialic acids are being explored as potential biomarkers for various diseases. Their levels can change in response to pathological conditions, making them useful indicators for diagnosis and prognosis. For example, elevated levels of certain sialic acids have been associated with cancer progression, while changes in sialic acid expression may be linked to neurodegenerative diseases.In conclusion, the study of sialic acids is a vibrant field that bridges fundamental science and clinical applications. As we continue to unravel the complexities of these fascinating molecules, we open new avenues for therapeutic interventions and enhance our understanding of health and disease. The significance of sialic acids in various biological processes underscores the intricate relationships between cellular structures and functions, highlighting the importance of ongoing research in this area.

在生物化学领域，术语sialic指的是一类通常存在于糖蛋白和糖脂的糖链末端的九碳糖。这些糖在多种生物过程中发挥着至关重要的作用，包括细胞信号传导、免疫反应和细胞识别。sialic酸在细胞表面的存在可以影响细胞之间以及与病原体之间的相互作用，这使得它们成为免疫学和癌症生物学研究的重点之一。最常被研究的sialic酸类型是N-乙酰神经氨酸（Neu5Ac），它广泛分布于动物组织中。这种特定的sialic酸参与了许多生理功能。例如，它有助于细胞表面的负电荷，这有助于排斥其他带负电的实体，如细菌和病毒。这一特性对于维持细胞的完整性和防止感染至关重要。此外，sialic酸已知与免疫反应的调节有关。它们可以作为细胞表面的“自我”标记，帮助免疫系统区分身体自身的细胞和外来入侵者。当sialic酸残基被去除或改变时，可能会向免疫系统发出信号，表明该细胞受损或感染，从而触发免疫反应。这对理解自身免疫性疾病和开发可以操控这些途径的治疗方法具有重要意义。在癌症的背景下，肿瘤细胞上sialic酸的表达也会影响其行为。肿瘤细胞通常表现出改变的sialic酸谱，这可能增强它们逃避免疫系统的能力。例如，一些癌症可能过度表达特定的sialic酸，从而形成一种保护屏障，抑制免疫检测和摧毁。理解这些机制对于开发能够破坏肿瘤隐藏能力的靶向癌症疗法至关重要。对sialic酸的研究不仅限于基础生物学；它在医学和生物技术方面有实际应用。例如，治疗性蛋白质上的sialic酸的存在可以影响其稳定性、分布和疗效。生物制药公司通常会工程化糖基化模式，包括sialic酸含量，以优化药物性能并减少潜在副作用。此外，sialic酸还被探索作为各种疾病的潜在生物标志物。它们的水平可以在病理状况下发生变化，使其成为诊断和预后的有用指标。例如，某些sialic酸水平的升高与癌症进展有关，而sialic酸表达的变化可能与神经退行性疾病相关。总之，sialic酸的研究是一个充满活力的领域，连接了基础科学和临床应用。随着我们继续揭示这些迷人分子的复杂性，我们为治疗干预开辟了新的途径，并增强了我们对健康和疾病的理解。sialic酸在各种生物过程中的重要性突显了细胞结构和功能之间复杂关系的重要性，强调了这一领域持续研究的重要性。