docking strain

简明释义

进坞期变形

英英释义

例句

1.The research focused on the effects of docking strain 对接应变 in marine vessel connections.

该研究集中于海洋船舶连接中的对接应变影响。

2.During the simulation, we observed significant docking strain 对接应变 at the joint interfaces.

在模拟过程中，我们观察到关节接口处的显著对接应变。

3.Engineers measured the docking strain 对接应变 to ensure the structural integrity of the spacecraft.

工程师测量了对接应变，以确保航天器的结构完整性。

4.In robotic arms, managing docking strain 对接应变 is crucial for precise movements.

在机器人手臂中，管理对接应变对于精确运动至关重要。

5.The software update improved the handling of the docking strain 对接应变 during the loading process.

软件更新改善了在加载过程中对接应变的处理。

作文

In the field of biochemistry and molecular biology, the term docking strain refers to the conformational changes that a molecule undergoes when it binds to a target protein. This concept is crucial for understanding how drugs interact with their biological targets. When a potential drug molecule approaches a protein, it must fit into the protein's active site, which often requires specific changes in its shape and orientation. The docking strain can be thought of as the energy cost associated with these conformational adjustments. A lower docking strain indicates a more favorable interaction, suggesting that the drug will bind more effectively and produce a therapeutic effect.The importance of minimizing docking strain cannot be overstated. In drug design, researchers strive to create molecules that not only fit well into the target site but also maintain stability during the binding process. High docking strain can lead to unstable complexes that may dissociate quickly, reducing the efficacy of the drug. Therefore, computational methods are often employed to predict and optimize the binding affinity of drug candidates by assessing their docking strain against various target proteins.Moreover, the concept of docking strain extends beyond just drug discovery. It plays a significant role in enzyme-substrate interactions, where the substrate must also adapt to fit into the enzyme's active site. Understanding the docking strain involved in these interactions can provide insights into enzyme kinetics and regulation, offering valuable information for biochemical research.In conclusion, the term docking strain encapsulates the challenges faced by molecules during the binding process to proteins. By studying and optimizing docking strain, scientists can enhance drug design, improve therapeutic outcomes, and deepen our understanding of molecular interactions in biological systems. As research progresses, the implications of docking strain will continue to shape the future of biochemistry and pharmacology, leading to more effective and targeted therapies for various diseases.

在生物化学和分子生物学领域，术语docking strain指的是分子在与目标蛋白结合时所经历的构象变化。这个概念对于理解药物如何与其生物靶标相互作用至关重要。当潜在药物分子接近蛋白质时，它必须适应蛋白质的活性位点，这通常需要其形状和方向的特定变化。docking strain可以被视为这些构象调整所需的能量成本。较低的docking strain表示更有利的相互作用，表明药物将更有效地结合并产生治疗效果。降低docking strain的重要性不容小觑。在药物设计中，研究人员努力创造不仅能够很好地适应靶位点而且在结合过程中保持稳定的分子。高docking strain可能导致不稳定的复合物，这些复合物可能迅速解离，从而降低药物的疗效。因此，通常采用计算方法来预测和优化药物候选者的结合亲和力，通过评估它们相对于各种目标蛋白的docking strain。此外，docking strain的概念不仅限于药物发现。它在酶-底物相互作用中也发挥着重要作用，其中底物也必须适应酶的活性位点。理解这些相互作用中涉及的docking strain可以提供对酶动力学和调控的深入见解，为生化研究提供宝贵的信息。总之，术语docking strain概括了分子在与蛋白质结合过程中面临的挑战。通过研究和优化docking strain，科学家可以增强药物设计，提高治疗效果，并加深我们对生物系统中分子相互作用的理解。随着研究的进展，docking strain的影响将继续塑造生物化学和药理学的未来，导致针对各种疾病的更有效和更具针对性的治疗方案。