dissociation constant

简明释义

分解常数

英英释义

例句

1.Researchers often measure the dissociation constant to evaluate drug efficacy.

研究人员常常测量dissociation constant（解离常数）来评估药物的有效性。

2.A lower dissociation constant indicates a stronger binding affinity between the ligand and the receptor.

较低的dissociation constant（解离常数）表明配体与受体之间的结合亲和力更强。

3.The dissociation constant of a weak acid helps predict its strength in solution.

弱酸的dissociation constant（解离常数）有助于预测其在溶液中的强度。

4.The dissociation constant can be used to calculate the concentration of free ions in solution.

可以使用dissociation constant（解离常数）来计算溶液中自由离子的浓度。

5.In biochemistry, the dissociation constant is crucial for understanding enzyme-substrate interactions.

在生物化学中，dissociation constant（解离常数）对于理解酶-底物相互作用至关重要。

作文

The concept of dissociation constant is pivotal in the field of chemistry, particularly in understanding chemical equilibria. The dissociation constant (often represented as Kd) quantifies the extent to which a compound dissociates into its constituent parts in a solution. This parameter is crucial for predicting how substances interact in various environments, including biological systems. For instance, enzymes and substrates interact based on their affinity, which can be described using the dissociation constant. A lower dissociation constant indicates a higher affinity between the two molecules, meaning they are more likely to remain bound together rather than dissociate. Conversely, a higher dissociation constant suggests a weaker interaction, leading to a greater likelihood of separation.Understanding the dissociation constant also has practical implications in pharmacology. Drugs often function by binding to specific receptors in the body, and the strength of this binding can be assessed through the dissociation constant. For example, if a drug has a low dissociation constant, it means that it binds tightly to its target receptor, which can result in prolonged effects. This characteristic is essential when designing drugs to ensure they have the desired therapeutic effects without causing significant side effects due to off-target interactions.In biochemical reactions, the dissociation constant helps in understanding the dynamics of enzyme-substrate complexes. Enzymes are biological catalysts that speed up reactions, and their efficiency often depends on how well they can bind to their substrates. By studying the dissociation constant, researchers can determine the optimal conditions for enzyme activity, including pH and temperature, which can significantly affect the binding affinity.Moreover, the dissociation constant is not only relevant in isolated systems but also plays a critical role in complex biological processes. For instance, in cellular signaling pathways, the binding of hormones to their receptors can be analyzed through the dissociation constant. Understanding these interactions can lead to advancements in targeted therapies for diseases such as cancer, where the signaling pathways often become dysregulated.In summary, the dissociation constant is a fundamental concept that provides insights into the behavior of molecules in a variety of contexts, from simple chemical reactions to complex biological systems. By mastering this concept, one can gain a deeper appreciation of the underlying principles that govern molecular interactions and their implications in real-world applications. Whether in the laboratory or in clinical settings, knowledge of the dissociation constant is invaluable for scientists and healthcare professionals alike, as it informs decisions that can lead to significant advancements in health and medicine.

“解离常数”这一概念在化学领域中至关重要，特别是在理解化学平衡方面。“解离常数”（通常表示为Kd）量化了化合物在溶液中解离为其组成部分的程度。这个参数对于预测物质在各种环境中的相互作用至关重要，包括生物系统。例如，酶和底物之间的相互作用基于它们的亲和力，这可以通过“解离常数”来描述。较低的“解离常数”表示两个分子之间的亲和力较高，这意味着它们更可能保持结合而不是解离。相反，较高的“解离常数”则表明相互作用较弱，从而导致分离的可能性增加。理解“解离常数”在药理学中也具有实际意义。药物通常通过与体内特定受体结合来发挥作用，而这种结合的强度可以通过“解离常数”来评估。例如，如果一种药物具有较低的“解离常数”，这意味着它与其靶受体紧密结合，可能会导致较长的效果。这一特性在药物设计中至关重要，以确保它们具有所需的治疗效果，同时不会因非靶向相互作用而引起显著的副作用。在生化反应中，“解离常数”有助于理解酶-底物复合物的动态。酶是加速反应的生物催化剂，其效率往往取决于它们与底物的结合能力。通过研究“解离常数”，研究人员可以确定酶活性的最佳条件，包括pH值和温度，这些条件可能会显著影响结合亲和力。此外，“解离常数”不仅在孤立系统中相关，而且在复杂的生物过程中也发挥着关键作用。例如，在细胞信号传导通路中，激素与其受体的结合可以通过“解离常数”进行分析。理解这些相互作用可以推动针对癌症等疾病的靶向疗法的发展，因为这些信号通路通常会失调。总之，“解离常数”是一个基本概念，提供了对各种背景下分子行为的深入理解，从简单的化学反应到复杂的生物系统。通过掌握这一概念，人们可以更深刻地理解支配分子相互作用的基本原理及其在现实应用中的意义。无论是在实验室还是临床环境中，对“解离常数”的了解对科学家和医疗专业人员来说都是无价的，因为它为能够带来健康和医学重大进展的决策提供了信息。