cisplatin

简明释义

英[sɪsˈplætɪn]美[sɪsˈpleɪtn]

n. 铂化合物，顺铂；顺氯氨铂

英英释义

单词用法

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例句

1.OBJECTIVE Study the influence of phosphonomycin on cisplatin renal toxicity.

目的考查磷霉素对顺铂肾毒性的影响。

2.When PIDD levels are artificially increased in human lung cancer cells, they become more resistant to cisplatin.

当PIDD水平在肺癌细胞人为增加时，它们对顺铂耐药性增强。

3.Aim To study the compatibility after mixing ondansetron injection, cisplatin for injection, and sodium chloride injection.

目的考察昂丹司琼注射液与注射用顺铂在氯化钠注射液中的稳定性。

4.Objective it is to discuss the antagonism of breviscapine on cochlea toxicity of Cisplatin.

目的探讨灯盏花素对顺铂耳蜗毒性的拮抗作用。

5.Objective to observe the efficacy, toxicity and survival of Taxotere and Cisplatin regimen in advanced non? - small cell lung cancer.

目的观察泰素蒂加顺铂方案治疗进展期非小细胞肺癌的临床疗效、毒副作用。

6.Objective To investigate the protective effect of curcumin(CMN) on cisplatin(CDDP)-induced nephrotoxicity in rats and plausible mechanism.

目的研究姜黄素（CMN）对顺铂（CDDP）所致肾损害的防护作用，并探讨其可能机制。

7.Methods:The inhibitory effects of Astragalus polysaccharides and cisplatin on growth of SGC-7901 cells was tested by the method of MTT.

方法：采用四甲基偶氮唑蓝（ MTT）法观察黄芪多糖和顺铂对胃癌SGC-7901细胞的抑制作用。

8.Conclusion Induction of cell apoptosis may be an important mechanism of anti tumor efficacy of cisplatin.

结论诱导细胞凋亡可能是顺铂抗肿瘤作用的重要机制。

9.The mechanism of action of cisplatin involves forming DNA cross-links that inhibit cancer cell replication.

顺铂的作用机制涉及形成DNA交联，抑制癌细胞复制。

10.Adverse effects of cisplatin can include nausea and kidney toxicity.

使用顺铂的副作用可能包括恶心和肾毒性。

11.Before starting cisplatin therapy, patients must undergo kidney function tests.

在开始顺铂治疗之前，患者必须进行肾功能测试。

12.Researchers are studying how cisplatin can be combined with other drugs to enhance its effectiveness.

研究人员正在研究如何将顺铂与其他药物结合以增强其效果。

13.The oncologist recommended treatment with cisplatin for the patient's testicular cancer.

肿瘤科医生建议使用顺铂治疗患者的睾丸癌。

作文

Cisplatin is a chemotherapy drug that has been widely used in the treatment of various types of cancer. This compound, which is a platinum-based antineoplastic agent, plays a significant role in modern oncology. Since its discovery in the 1960s, cisplatin (顺铂) has transformed cancer treatment protocols and has become a cornerstone for treating testicular, ovarian, bladder, and lung cancers.The mechanism of action of cisplatin involves the formation of DNA cross-links, which ultimately leads to cell death. When cisplatin enters the cancer cell, it gets activated and binds to the DNA, causing structural changes. This interaction prevents the DNA from replicating properly, thereby inhibiting the cancer cell's ability to grow and divide. The effectiveness of cisplatin is especially notable in rapidly dividing cells, which is characteristic of many tumors.Despite its efficacy, the use of cisplatin is not without challenges. One of the significant side effects includes nephrotoxicity, which can lead to kidney damage. Patients undergoing treatment with cisplatin often require close monitoring of their renal function. Other common side effects include nausea, vomiting, and myelosuppression, which is a decrease in bone marrow activity resulting in lower blood cell counts. These side effects can significantly impact a patient's quality of life and may necessitate supportive care or dose adjustments.Moreover, the development of resistance to cisplatin is a significant concern in clinical settings. Some tumors may become resistant to the drug over time, limiting its effectiveness. Researchers are continuously investigating ways to overcome this resistance, such as combining cisplatin with other therapeutic agents or using novel delivery methods to enhance its efficacy.In recent years, there has been a growing interest in personalized medicine, which aims to tailor cancer treatment based on individual patient characteristics. This approach may involve genetic testing to determine how a patient's tumor might respond to cisplatin and whether they are likely to experience severe side effects. By understanding the specific molecular profile of a tumor, oncologists can make more informed decisions about treatment options, potentially improving outcomes for patients.In conclusion, cisplatin (顺铂) remains an essential tool in the fight against cancer. Its ability to effectively target and kill cancer cells has saved countless lives and continues to be a subject of extensive research. While challenges such as side effects and drug resistance exist, ongoing advancements in cancer treatment and personalized medicine hold promise for enhancing the efficacy and safety of cisplatin. As we continue to learn more about this powerful drug, it is crucial to balance its benefits with the potential risks to provide the best possible care for cancer patients.

顺铂是一种化疗药物，广泛用于治疗各种类型的癌症。这种化合物是一种基于铂的抗肿瘤药物，在现代肿瘤学中发挥着重要作用。自20世纪60年代发现以来，cisplatin（顺铂）改变了癌症治疗方案，并成为治疗睾丸癌、卵巢癌、膀胱癌和肺癌的基石。cisplatin的作用机制涉及DNA交联的形成，最终导致细胞死亡。当cisplatin进入癌细胞时，它被激活并与DNA结合，导致结构变化。这种相互作用阻止DNA正常复制，从而抑制癌细胞的生长和分裂。cisplatin的有效性在快速分裂的细胞中尤其显著，这正是许多肿瘤的特征。尽管其疗效显著，但使用cisplatin并非没有挑战。其中一个主要副作用是肾毒性，可能导致肾脏损伤。接受cisplatin治疗的患者通常需要密切监测其肾功能。其他常见副作用包括恶心、呕吐和骨髓抑制，即骨髓活动减少，导致血细胞计数降低。这些副作用可能严重影响患者的生活质量，并可能需要支持性护理或调整剂量。此外，耐药性的产生是临床环境中的一个重大问题。一些肿瘤可能会随着时间的推移对cisplatin产生耐药性，从而限制其有效性。研究人员正在不断调查克服这种耐药性的方法，例如将cisplatin与其他治疗药物结合使用或采用新颖的给药方法以增强其疗效。近年来，个性化医学的兴趣日益增长，旨在根据个体患者特征量身定制癌症治疗。这种方法可能涉及基因检测，以确定患者的肿瘤可能如何对cisplatin作出反应，以及他们是否可能经历严重的副作用。通过了解肿瘤的特定分子特征，肿瘤科医生可以更明智地做出治疗选择，从而潜在改善患者的预后。总之，cisplatin（顺铂）仍然是抗击癌症的重要工具。它有效靶向并杀死癌细胞的能力拯救了无数生命，并继续成为广泛研究的对象。尽管存在诸如副作用和药物耐药性等挑战，但癌症治疗和个性化医学的持续进展为提高cisplatin的疗效和安全性带来了希望。随着我们对这种强大药物了解的不断加深，平衡其益处与潜在风险至关重要，以便为癌症患者提供最佳护理。