asparaginase

简明释义

英[ˌæspəˈrædʒɪneɪs]美[əˈspærədʒəˌnes;əˈspærədʒəˌne

n. [生化] 天冬酰胺酶

英英释义

单词用法

同义词

反义词

例句

1.Objective: To investigate the characteristics of adverse drug reaction (ADR) in children caused by L-asparaginase (L-ASP) from clinical practice, and to provide reference for rational use of drugs.

目的：以临床实例出发探讨左旋门冬酰胺酶不良反应在儿童的发生特点，为临床用药安全提供依据。

2.Purpose: To give an appraisal of recombinant L-asparaginase.

目的：对重组l天冬酰胺酶进行鉴定。

3.L asparaginase is a very effective anti tumor agent.

天冬酰胺酶具有显著的抗肿瘤作用。

4.Conclusion: The application of recombinant L-asparaginase was promising.

结论：重组l天冬酰胺酶具有较好的应用前景。

5.The more we learn about the molecular interactions between these cells the more likely we'll be able to enhance the anti-leukemic action of asparaginase and perhaps other anti-leukemic drugs as well.

这些细胞间分子的相互作用我们知道的越多，我们也就越能加强天冬酰胺酶或者其他的抗白血病药物的作用。

6.Streptokinase and urokinase are important in thrombolytics, and asparaginase is used as a cytostatic agent in the treatment of leukemia.

链激酶和尿激酶溶栓是重要的，是天冬酰胺酶在治疗白血病细胞生长剂。

7.Objective Evaluate the uncertainty of Asparaginase for injection titer measurement.

目的：对门冬酰胺酶效价测量的不确定度进行评定。

8.In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase I activity.

在具体实施方式中，本发明提供了用于诱导和稳定腈水合酶活性、酰胺酶活性和天冬酰胺酶I活性的方法。

9.The more we learn about the molecular interactions between these cells the more likely we'll be able to enhance the anti-leukemic action of asparaginase and perhaps other anti-leukemic drugs as well.

这些细胞间分子的相互作用我们知道的越多，我们也就越能加强天冬酰胺酶或者其他的抗白血病药物的作用。

10.Side effects of asparaginase can include allergic reactions and pancreatitis.

使用天冬氨酸酶的副作用可能包括过敏反应和胰腺炎。

11.Monitoring liver function is important for patients receiving asparaginase therapy.

接受天冬氨酸酶治疗的患者需要监测肝功能。

12.The mechanism of action of asparaginase involves depleting asparagine levels in the body.

天冬氨酸酶的作用机制涉及消耗体内的天冬氨酸水平。

13.The doctor prescribed asparaginase for the patient's leukemia treatment.

医生为患者的白血病治疗开了天冬氨酸酶。

14.Children with acute lymphoblastic leukemia often receive asparaginase as part of their chemotherapy regimen.

急性淋巴细胞白血病的儿童通常在化疗方案中接受天冬氨酸酶。

作文

Asparaginase is an enzyme that plays a crucial role in the treatment of certain types of cancer, particularly acute lymphoblastic leukemia (ALL). This enzyme works by breaking down the amino acid asparagine, which is essential for the growth and survival of some cancer cells. In patients with ALL, their bodies often cannot produce enough asparagine on their own, making them dependent on external sources. By administering asparaginase, doctors can effectively starve these cancer cells of the nutrients they need to proliferate. The use of asparaginase in chemotherapy has revolutionized the way we approach cancer treatment, providing a targeted method to combat this aggressive disease.The discovery of asparaginase dates back to the 1960s when researchers began exploring its potential in oncology. Initially, it was derived from E. coli bacteria, which produce the enzyme naturally. Later, recombinant DNA technology allowed for the production of asparaginase from other sources, increasing its availability and effectiveness. The ability to produce this enzyme in large quantities has made it a staple in cancer treatment protocols around the world.One of the significant advantages of using asparaginase is its relatively low toxicity compared to traditional chemotherapy agents. While many chemotherapy drugs target rapidly dividing cells indiscriminately, leading to side effects such as hair loss and nausea, asparaginase specifically targets the metabolic needs of leukemic cells. This selectivity means that patients often experience fewer severe side effects, allowing for a better quality of life during treatment.However, the use of asparaginase is not without its challenges. Some patients may develop allergic reactions to the enzyme, which can range from mild to severe. Additionally, monitoring is required to manage potential complications such as pancreatitis and blood clotting disorders. Therefore, while asparaginase is a powerful tool in the fight against cancer, it must be administered with caution and under close medical supervision.In recent years, research has continued to explore the potential applications of asparaginase beyond leukemia. Studies are investigating its efficacy in treating other malignancies, including solid tumors, where the role of asparagine in tumor metabolism may provide new avenues for therapy. This ongoing research highlights the importance of asparaginase not only as a treatment option but also as a subject of scientific inquiry that could lead to further advancements in cancer care.In conclusion, asparaginase represents a significant advancement in the treatment of specific cancers, particularly acute lymphoblastic leukemia. Its ability to selectively target cancer cell metabolism offers a more tailored approach to chemotherapy, resulting in improved patient outcomes and reduced side effects. As research continues to expand our understanding of this enzyme, we may uncover even more ways to utilize asparaginase in the battle against cancer, ultimately leading to better therapies and increased survival rates for patients worldwide.

天冬氨酸酶是一种在某些类型癌症的治疗中发挥重要作用的酶，特别是急性淋巴细胞白血病（ALL）。这种酶通过分解氨基酸天冬氨酸来工作，天冬氨酸是某些癌细胞生长和存活所必需的。在患有ALL的患者中，他们的身体通常无法自行产生足够的天冬氨酸，这使他们依赖外部来源。通过施用天冬氨酸酶，医生可以有效地使这些癌细胞饥饿，无法获取它们繁殖所需的营养。天冬氨酸酶在化疗中的使用彻底改变了我们对抗癌症的方式，提供了一种针对性的方法来对抗这种侵袭性疾病。天冬氨酸酶的发现可以追溯到20世纪60年代，当时研究人员开始探索其在肿瘤学中的潜力。最初，它是从大肠杆菌中提取的，这种细菌自然产生这种酶。后来，重组DNA技术使得从其他来源生产天冬氨酸酶成为可能，增加了其可用性和有效性。能够大量生产这种酶使其成为世界各地癌症治疗方案的主流。使用天冬氨酸酶的一个显著优势是与传统化疗药物相比，其毒性相对较低。虽然许多化疗药物无差别地针对快速分裂的细胞，导致诸如脱发和恶心等副作用，但天冬氨酸酶专门针对白血病细胞的代谢需求。这种选择性意味着患者通常经历较少的严重副作用，从而在治疗期间更好地生活质量。然而，使用天冬氨酸酶并非没有挑战。一些患者可能会对该酶产生过敏反应，这种反应可以从轻微到严重。此外，需要监测以管理潜在的并发症，如胰腺炎和血液凝块。因此，虽然天冬氨酸酶是对抗癌症的强大工具，但必须谨慎使用，并在密切的医疗监督下进行。近年来，研究继续探索天冬氨酸酶在白血病之外的潜在应用。研究正在调查其在治疗其他恶性肿瘤中的有效性，包括固体肿瘤，在这些肿瘤中，天冬氨酸在肿瘤代谢中的作用可能提供新的治疗途径。这项持续的研究突显了天冬氨酸酶的重要性，不仅作为一种治疗选择，而且作为科学探究的主题，可能会导致癌症护理的进一步进展。总之，天冬氨酸酶代表了在特定癌症治疗方面的重要进展，尤其是急性淋巴细胞白血病。它能够选择性地针对癌细胞的代谢提供了更具针对性的化疗方法，从而改善患者的预后并减少副作用。随着研究继续扩展我们对这种酶的理解，我们可能会发现更多利用天冬氨酸酶对抗癌症的新方法，最终导致更好的治疗和全球患者的生存率提高。