radiation insensitivity

简明释义

辐射不灵敏性

英英释义

例句

1.Scientists aim to understand the genetic basis of radiation insensitivity in these resilient organisms.

科学家们旨在了解这些抗逆生物中辐射不敏感性的遗传基础。

2.The development of materials with radiation insensitivity is crucial for building structures near nuclear power plants.

开发具有辐射不敏感性的材料对于在核电站附近建造结构至关重要。

3.The discovery of radiation insensitivity in some microorganisms could revolutionize our approach to space exploration.

某些微生物中发现的辐射不敏感性可能会彻底改变我们对太空探索的看法。

4.The new breed of bacteria exhibits radiation insensitivity, allowing it to thrive in high-radiation environments.

这种新型细菌表现出辐射不敏感性，使其能够在高辐射环境中生存。

5.Researchers are studying the radiation insensitivity of certain plant species to develop crops that can withstand nuclear fallout.

研究人员正在研究某些植物物种的辐射不敏感性，以开发能够抵御核辐射的作物。

作文

In the field of biology and medicine, the term radiation insensitivity refers to the ability of certain cells or organisms to withstand exposure to ionizing radiation without undergoing significant damage. This phenomenon is particularly important in understanding how some cancer cells can survive radiation therapy, which is a common treatment for various types of cancer. The concept of radiation insensitivity is crucial in developing more effective treatment strategies that target these resilient cells while minimizing harm to healthy tissues.Radiation therapy works by damaging the DNA of cancer cells, leading to cell death or the inability to replicate. However, some cancer cells possess mechanisms that allow them to repair this damage efficiently, making them resistant to the effects of radiation. This resistance is what we refer to as radiation insensitivity. Understanding the underlying mechanisms of this insensitivity can provide valuable insights into cancer treatment and help researchers develop drugs that can sensitize resistant tumors to radiation.One of the key factors contributing to radiation insensitivity is the presence of specific proteins that facilitate DNA repair. For instance, proteins involved in the homologous recombination repair pathway play a significant role in repairing double-strand breaks caused by radiation. Tumors with high levels of these repair proteins often show increased resistance to radiation therapy, as they can effectively mend the damage inflicted by the treatment.Moreover, the tumor microenvironment can also influence radiation insensitivity. Factors such as hypoxia (low oxygen levels) within tumors can create conditions that promote survival and resistance to radiation. Hypoxic cells are often less sensitive to radiation because the lack of oxygen impairs the formation of free radicals, which are crucial for damaging DNA during radiation exposure. Consequently, understanding the tumor microenvironment's role in radiation insensitivity can lead to innovative approaches to enhance the efficacy of radiation therapy.Researchers are actively exploring various strategies to overcome radiation insensitivity. One promising approach involves combining radiation therapy with targeted therapies that inhibit DNA repair pathways. By blocking the mechanisms that allow cancer cells to repair their DNA, these combined treatments aim to increase the effectiveness of radiation therapy and reduce the likelihood of tumor recurrence.Additionally, immunotherapy has emerged as a potential strategy to address radiation insensitivity. Certain immune cells can be activated to recognize and attack cancer cells that have survived radiation treatment. By enhancing the immune response against these resistant cells, researchers hope to improve patient outcomes and reduce the chances of treatment failure.In conclusion, understanding radiation insensitivity is vital for advancing cancer treatment. By identifying the mechanisms that confer resistance to radiation therapy, researchers can develop more effective strategies to combat cancer. As our knowledge of this phenomenon grows, so too does the potential for improved therapeutic options that can ultimately lead to better outcomes for patients fighting against cancer.

在生物学和医学领域，术语辐射不敏感性指的是某些细胞或生物体在暴露于电离辐射时能够承受而不发生显著损伤的能力。这一现象在理解某些癌细胞如何在放疗中存活时尤为重要，而放疗是多种类型癌症的常见治疗方法。辐射不敏感性的概念对于开发更有效的治疗策略至关重要，这些策略旨在针对这些顽强的细胞，同时最小化对健康组织的伤害。放疗通过损伤癌细胞的DNA来发挥作用，导致细胞死亡或无法复制。然而，一些癌细胞具有能够有效修复这种损伤的机制，使它们对放疗的影响产生抵抗力。这种抵抗力就是我们所称的辐射不敏感性。理解这种不敏感性的基本机制可以为癌症治疗提供有价值的见解，并帮助研究人员开发能够使耐药肿瘤对辐射更加敏感的药物。导致辐射不敏感性的关键因素之一是特定蛋白质的存在，这些蛋白质促进DNA修复。例如，参与同源重组修复途径的蛋白质在修复放射引起的双链断裂中发挥重要作用。具有高水平这些修复蛋白的肿瘤通常表现出对放疗的增强抵抗力，因为它们能够有效地修复治疗造成的损伤。此外，肿瘤微环境也会影响辐射不敏感性。肿瘤内的缺氧（低氧水平）等因素可能会创造出促进生存和抵抗辐射的条件。缺氧细胞通常对辐射不太敏感，因为缺乏氧气会削弱自由基的形成，而自由基在辐射暴露期间对DNA造成损伤。因此，了解肿瘤微环境在辐射不敏感性中的作用可能会导致创新的方法，以增强放疗的有效性。研究人员正在积极探索克服辐射不敏感性的各种策略。一种有前景的方法是将放疗与靶向治疗结合使用，这些靶向治疗抑制DNA修复途径。通过阻断允许癌细胞修复其DNA的机制，这些联合治疗旨在提高放疗的有效性，并减少肿瘤复发的可能性。此外，免疫疗法已经成为应对辐射不敏感性的潜在策略。某些免疫细胞可以被激活以识别和攻击在放疗中存活的癌细胞。通过增强对这些耐药细胞的免疫反应，研究人员希望改善患者的预后，并减少治疗失败的可能性。总之，理解辐射不敏感性对于推进癌症治疗至关重要。通过识别赋予放疗抵抗力的机制，研究人员可以开发更有效的策略来对抗癌症。随着我们对这一现象的认识不断加深，改善治疗选择的潜力也在不断增长，这最终可以为与癌症斗争的患者带来更好的结果。