sulfathiazole

简明释义

英[ˌsʌlfəˈθaɪəzəʊl]美[ˌsʌlfəˈθaɪəˌzoʊl]

n. 磺胺塞唑（等于 sulphathiazole）

英英释义

单词用法

同义词

反义词

例句

1.The 38 patients in the contrast group orally take Sulfathiazole tablets for treatment.

对照组38例，口服柳氮磺胺嘧啶片治疗。

2.Objective: To introduce a preparation method and quality control of sulfathiazole cod -liver oil cream.

目的：介绍磺胺噻唑鱼肝油乳剂制备方法及质量控制。

3.Objective: To introduce a preparation method and quality control of sulfathiazole cod -liver oil cream.

目的：介绍磺胺噻唑鱼肝油乳剂制备方法及质量控制。

4.Patients should inform their doctors if they are allergic to sulfathiazole.

患者应告知医生他们是否对磺胺噻唑过敏。

5.The pharmacist recommended sulfathiazole as a topical treatment for skin infections.

药剂师推荐使用磺胺噻唑作为皮肤感染的局部治疗。

6.In veterinary medicine, sulfathiazole is often used to treat infections in animals.

在兽医学中，磺胺噻唑常用于治疗动物感染。

7.Side effects of sulfathiazole may include nausea and headache.

使用磺胺噻唑的副作用可能包括恶心和头痛。

8.The doctor prescribed sulfathiazole for the bacterial infection.

医生开了磺胺噻唑来治疗细菌感染。

作文

Sulfathiazole, a sulfonamide antibiotic, has been used in the treatment of various bacterial infections since its discovery in the 1930s. This compound is particularly effective against a range of Gram-positive and some Gram-negative bacteria. The mechanism of action of sulfathiazole involves the inhibition of bacterial growth by interfering with the synthesis of folic acid, which is essential for bacterial reproduction. By mimicking para-aminobenzoic acid (PABA), sulfathiazole effectively blocks the enzyme dihydropteroate synthase, thereby preventing the bacteria from producing folate necessary for DNA and RNA synthesis.The historical significance of sulfathiazole cannot be overstated; it paved the way for the development of other sulfonamide drugs and antibiotics. During World War II, sulfathiazole was widely used to treat infections among soldiers, significantly reducing mortality rates due to bacterial infections. Its introduction marked a turning point in medical history, as it was one of the first antibiotics that could be synthesized and mass-produced.However, with the advent of penicillin and other advanced antibiotics, the use of sulfathiazole has declined over the years. Despite this decline, it remains an important part of the pharmaceutical landscape, especially in developing countries where access to more modern antibiotics may be limited. It is still used in certain formulations for treating skin infections and urinary tract infections, showcasing its continued relevance.One notable application of sulfathiazole is in the veterinary field. It is often used to treat infections in animals, particularly in livestock, where it helps prevent the spread of disease in herds. The use of sulfathiazole in veterinary medicine underscores the importance of this antibiotic beyond human health, highlighting its role in agriculture and food production.Despite its benefits, the use of sulfathiazole is not without risks. Like many antibiotics, it can lead to the development of resistance if not used judiciously. Bacterial resistance to sulfathiazole has been documented, prompting healthcare providers to be cautious in its prescription. This concern emphasizes the need for ongoing research and monitoring of antibiotic usage to ensure that effective treatments remain available.In conclusion, sulfathiazole is a significant antibiotic that has played a crucial role in the fight against bacterial infections for nearly a century. Its ability to inhibit bacterial growth through folic acid synthesis disruption has made it a valuable tool in both human and veterinary medicine. While its use has diminished in favor of newer antibiotics, sulfathiazole continues to be relevant, particularly in resource-limited settings. As we move forward, it is essential to balance the use of such antibiotics with the need to prevent resistance, ensuring that they remain effective for future generations.

磺胺噻唑（sulfathiazole）是一种磺胺类抗生素，自20世纪30年代发现以来，已广泛用于治疗各种细菌感染。这种化合物对一系列革兰阳性和部分革兰阴性细菌特别有效。sulfathiazole的作用机制是通过干扰叶酸的合成来抑制细菌的生长，而叶酸对细菌的繁殖至关重要。通过模拟对氨基苯甲酸（PABA），sulfathiazole有效地阻止了二氢蝶酸合酶这种酶，从而防止细菌产生DNA和RNA合成所需的叶酸。sulfathiazole的历史意义不容小觑；它为其他磺胺类药物和抗生素的发展铺平了道路。在第二次世界大战期间，sulfathiazole被广泛用于治疗士兵的感染，显著降低了因细菌感染导致的死亡率。它的引入标志着医学历史的一个转折点，因为它是第一种可以合成和大规模生产的抗生素。然而，随着青霉素和其他先进抗生素的出现，sulfathiazole的使用在近年来有所下降。尽管如此，它仍然是制药领域的重要组成部分，特别是在发展中国家，那里对现代抗生素的获取可能有限。它仍然在某些制剂中用于治疗皮肤感染和尿路感染，展示了其持续的相关性。sulfathiazole的一个显著应用是在兽医领域。它常用于治疗动物的感染，特别是在牲畜中，有助于防止疾病在群体中的传播。在兽医医学中使用sulfathiazole突显了这种抗生素在超越人类健康方面的重要性，强调了它在农业和食品生产中的作用。尽管有其好处，sulfathiazole的使用并非没有风险。与许多抗生素一样，如果不加以谨慎使用，它可能导致耐药性的产生。已经记录到细菌对sulfathiazole的耐药性，这促使医疗提供者在开处方时保持谨慎。这一担忧强调了对抗生素使用进行持续研究和监测的必要性，以确保有效治疗仍然可用。总之，sulfathiazole是一种重要的抗生素，在近一个世纪的抗击细菌感染的斗争中发挥了关键作用。它通过干扰叶酸合成抑制细菌生长的能力使其成为人类和兽医医学中的宝贵工具。尽管其使用因更新的抗生素而减少，但sulfathiazole仍然保持相关性，特别是在资源有限的环境中。随着我们向前发展，平衡这种抗生素的使用与防止耐药性的需求至关重要，以确保它们在未来几代人中仍然有效。