vincristine

简明释义

英[vɪnˈkrɪstiːn]美[vɪnˈkrɪsˌtin]

n. [药] 长春新碱（一种抗肿瘤药）

英英释义

单词用法

同义词

反义词

例句

1.Microtubule dynamics test showed that S47 inhibited microtubule polymerization. Vincristine had a mechanism of action similar to that of S47.

微管微丝动力学试验证实，S47能抑制微管微丝的聚合，与长春新碱作用机理相同。

2.Conclusions The process is simple and reasonable with good reproducibility. It is effective to enrich highly purified vinblastine and vincristine.

结论该工艺简便合理，重复性良好，能得到高纯度的长春碱和长春新碱。

3.PURPOSE: the current standard therapy for patients with diffuse large B-cell lymphoma (DLBCL) is rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP).

背景：目前，弥漫大b细胞性淋巴瘤(DLBCL)的标准治疗方案为利妥昔单抗联合CHOP方案化疗(R - CHOP)。

4.Conclusions: Long-circulating liposome is a good drug delivery system for vincristine.

结论：长循环脂质体是长春新碱的理想载体。

5.OBJECTIVE To study the physical and chemical stability of vincristine sulfate-blank liposomes.

目的考察三瓶装硫酸长春新碱脂质体中空白脂质体的物理、化学稳定性。

6.And we've clearly seen children's performance in academic and on neuropsychological tests really be adversely or negatively affected when the child is getting the vincristine.

当孩子们服用长春新碱，我们很明显看到他们在学术和神经心理测试上表现变差。

7.Chemotherapy was given according to the protocol which consisted of lomustine, cisplatinum and vincristine after radiotherapy, but the patients were not given intrathecal chemotherapy.

所有患儿于放疗后接受长春新碱、环己亚硝脲、顺铂方案化疗，所有患者均未行鞘内化疗。

8.Objective To investigate the release rate and pharmacodynamics in vitro of of vincristine sulfate liposomes.

目的考察硫酸长春新碱脂质体的体外释放度及其药效。

9.Research shows that vincristine can be effective in treating certain types of cancer.

研究表明，维克利汀对某些类型的癌症治疗有效。

10.Patients receiving vincristine may experience side effects such as hair loss and constipation.

接受维克利汀治疗的患者可能会出现如脱发和便秘等副作用。

11.The nurse explained that vincristine is administered intravenously.

护士解释说，维克利汀是通过静脉注射给药的。

12.The doctor prescribed vincristine for the patient's leukemia treatment.

医生为病人的白血病治疗开了维克利汀。

13.During chemotherapy, vincristine is often combined with other drugs to enhance its effectiveness.

在化疗期间，维克利汀常常与其他药物联合使用以增强效果。

作文

Vincristine is a powerful chemotherapeutic agent that has been widely used in the treatment of various types of cancer, particularly pediatric leukemia and lymphoma. Derived from the periwinkle plant, it plays a crucial role in modern oncology. The mechanism of action of vincristine involves the inhibition of microtubule formation during cell division, which effectively halts the proliferation of cancer cells. This unique property makes vincristine an essential component of combination chemotherapy regimens.The discovery of vincristine dates back to the 1960s when researchers were exploring the medicinal properties of the Vinca rosea plant. Initially, it was found to have remarkable effects on cancerous cells in laboratory settings, leading to further clinical trials. Over the years, vincristine has proven to be particularly effective against childhood cancers, such as acute lymphoblastic leukemia (ALL). Its ability to cross the blood-brain barrier also makes it valuable in treating central nervous system tumors.However, the use of vincristine is not without its challenges. Like many chemotherapy drugs, it can cause a range of side effects. Patients may experience peripheral neuropathy, which manifests as numbness or tingling in the extremities. Other potential side effects include constipation, hair loss, and increased risk of infection due to its impact on the immune system. Therefore, careful monitoring and supportive care are essential for patients undergoing treatment with vincristine.Despite these challenges, the importance of vincristine in cancer treatment cannot be overstated. It is often used in conjunction with other chemotherapeutic agents to enhance efficacy and reduce the likelihood of resistance. For instance, in the treatment of certain types of lymphoma, vincristine is combined with drugs like prednisone and cyclophosphamide to improve outcomes.Research continues to explore the full potential of vincristine. Scientists are investigating ways to optimize its delivery and minimize side effects. Some studies are focused on developing new formulations that can target cancer cells more precisely, thereby reducing damage to healthy tissues. Additionally, ongoing clinical trials aim to identify the most effective combinations of vincristine with other targeted therapies and immunotherapies.In conclusion, vincristine remains a cornerstone of cancer treatment, especially in pediatric populations. Its unique mechanism of action and effectiveness against various malignancies underscore its significance in medical practice. As research progresses, there is hope that advancements will lead to improved treatment protocols that enhance the benefits of vincristine while minimizing its adverse effects. The journey of vincristine from a natural product to a vital chemotherapeutic agent exemplifies the potential of scientific discovery in the fight against cancer. Through continued innovation and collaboration within the medical community, we can strive towards better outcomes for patients battling this devastating disease.

长春新碱是一种强效的化疗药物，广泛用于治疗各种类型的癌症，尤其是儿童白血病和淋巴瘤。它源自常春藤植物，在现代肿瘤学中发挥着至关重要的作用。长春新碱的作用机制涉及在细胞分裂过程中抑制微管形成，从而有效阻止癌细胞的增殖。这一独特特性使得长春新碱成为化疗联合方案的重要组成部分。长春新碱的发现可以追溯到20世纪60年代，当时研究人员正在探索常春藤植物的药用特性。最初，它在实验室环境中对癌细胞表现出显著效果，促使了进一步的临床试验。多年来，长春新碱已被证明对儿童癌症（如急性淋巴细胞白血病）特别有效。它能够穿透血脑屏障，这也使其在治疗中枢神经系统肿瘤方面具有价值。然而，使用长春新碱并非没有挑战。与许多化疗药物一样，它可能会导致一系列副作用。患者可能会出现周围神经病变，表现为四肢麻木或刺痛。其他潜在的副作用包括便秘、脱发和由于其对免疫系统影响而增加感染风险。因此，对于接受长春新碱治疗的患者，仔细监测和支持性护理至关重要。尽管面临这些挑战，长春新碱在癌症治疗中的重要性不容小觑。它通常与其他化疗药物联合使用，以增强疗效并减少耐药的可能性。例如，在某些类型的淋巴瘤治疗中，长春新碱与泼尼松和环磷酰胺等药物结合使用，以改善治疗效果。研究仍在继续探索长春新碱的全部潜力。科学家们正在研究优化其给药方式和最小化副作用的方法。一些研究集中在开发可以更精确靶向癌细胞的新制剂，从而减少对健康组织的损害。此外，正在进行的临床试验旨在确定长春新碱与其他靶向疗法和免疫疗法的最佳组合。总之，长春新碱仍然是癌症治疗的基石，尤其是在儿童人群中。其独特的作用机制和对各种恶性肿瘤的有效性突显了其在医学实践中的重要性。随着研究的进展，人们希望通过改进的治疗方案来增强长春新碱的益处，同时最小化其不良反应。长春新碱从一种天然产品发展为重要的化疗药物的历程，展示了科学发现对抗癌症的潜力。通过医疗界内持续的创新与合作，我们可以努力实现对抗这种毁灭性疾病的患者更好的治疗结果。