global alignment

简明释义

全局对准

英英释义

例句

1.Achieving global alignment 全球一致性 in product development can lead to a more streamlined process and better outcomes.

在产品开发中实现全球一致性可以导致更高效的流程和更好的结果。

2.The project manager emphasized the need for global alignment 全球一致性 in the project goals to avoid confusion among team members.

项目经理强调了在项目目标中需要全球一致性，以避免团队成员之间的混淆。

3.The conference aimed to foster global alignment 全球一致性 among international stakeholders on climate change policies.

会议旨在促进国际利益相关者在气候变化政策方面的全球一致性。

4.The team focused on achieving global alignment 全球一致性 in their marketing strategy to ensure all departments were on the same page.

团队专注于在他们的营销策略中实现全球一致性，以确保所有部门步调一致。

5.During the merger, it was crucial to establish global alignment 全球一致性 between the two companies' cultures.

在合并过程中，建立两家公司文化之间的全球一致性至关重要。

作文

In the field of bioinformatics, the term global alignment refers to a method used to align sequences of DNA, RNA, or proteins across their entire length. This technique is crucial for understanding the evolutionary relationships between different species and for identifying conserved sequences that may be functionally important. The process of global alignment involves comparing two or more sequences to find the best possible match by inserting gaps where necessary. By doing so, researchers can assess how similar the sequences are, which can provide insights into their biological functions.One of the most widely used algorithms for global alignment is the Needleman-Wunsch algorithm. This algorithm employs dynamic programming to systematically compare sequences and compute a score based on matches, mismatches, and gaps. The result is a comprehensive alignment that shows the best possible correspondence between the sequences being compared. The significance of global alignment lies in its ability to highlight regions of similarity that might indicate shared ancestry or functional characteristics.The application of global alignment extends beyond mere academic interest; it has practical implications in various fields such as medicine, genetics, and agriculture. For instance, by aligning the genome sequences of different organisms, scientists can identify genes that are conserved across species, which can lead to discoveries about gene function and regulation. In medical research, global alignment can help in identifying mutations associated with diseases, thereby aiding in the development of targeted therapies.Furthermore, global alignment plays a critical role in evolutionary biology. By aligning sequences from different species, researchers can construct phylogenetic trees that depict the evolutionary pathways of organisms. This allows scientists to trace the lineage of species and understand how they have diverged over time. In this context, global alignment not only provides a means of comparison but also serves as a tool for reconstructing the history of life on Earth.However, it is essential to acknowledge the limitations of global alignment. While it is powerful for comparing sequences of similar lengths, it may not be as effective for sequences that vary significantly in size or complexity. In such cases, local alignment methods, which focus on identifying the most similar subsequences, may be more appropriate. Despite these challenges, the importance of global alignment in advancing our understanding of biological systems cannot be overstated.In conclusion, global alignment is a fundamental concept in bioinformatics that enables the comparison of biological sequences across their entire length. Its applications in evolutionary biology, medicine, and genetics underscore its significance in modern science. As technology continues to advance, the methods for performing global alignment will likely become even more sophisticated, allowing for deeper insights into the complexities of life at the molecular level. Researchers must continue to refine these techniques to enhance their accuracy and applicability, ensuring that global alignment remains a vital tool in the exploration of biological data.

在生物信息学领域，术语全局比对指的是一种用于对DNA、RNA或蛋白质序列进行比对的方法，涉及到整个序列的长度。这种技术对于理解不同物种之间的进化关系以及识别可能在功能上重要的保守序列至关重要。全局比对的过程包括比较两个或多个序列，以找到最佳匹配，通过必要的插入空格来实现。通过这样做，研究人员可以评估序列的相似性，这可以提供有关其生物功能的见解。最广泛使用的全局比对算法之一是Needleman-Wunsch算法。该算法采用动态规划系统地比较序列，并根据匹配、错配和缺口计算得分。结果是一个全面的比对，显示所比较序列之间的最佳对应关系。全局比对的重要性在于它能够突出相似区域，这些区域可能表明共享的祖先或功能特征。全局比对的应用超出了单纯的学术兴趣；它在医学、遗传学和农业等多个领域具有实际意义。例如，通过对不同生物的基因组序列进行比对，科学家可以识别跨物种保守的基因，这可能导致对基因功能和调控的发现。在医学研究中，全局比对可以帮助识别与疾病相关的突变，从而有助于开发针对性的治疗方法。此外，全局比对在进化生物学中发挥着关键作用。通过对来自不同物种的序列进行比对，研究人员可以构建描绘生物进化路径的系统发育树。这使科学家能够追踪物种的谱系，并理解它们如何随时间演变。在这个背景下，全局比对不仅提供了一种比较手段，而且还作为重建地球生命历史的工具。然而，必须承认全局比对的局限性。虽然它在比较相似长度的序列时非常强大，但对于大小或复杂性差异显著的序列，它可能不那么有效。在这种情况下，局部比对方法可能更为合适，局部比对方法专注于识别最相似的子序列。尽管存在这些挑战，全局比对在推动我们理解生物系统方面的重要性不可低估。总之，全局比对是生物信息学中的一个基本概念，使得对生物序列进行全面的比较成为可能。它在进化生物学、医学和遗传学中的应用突显了其在现代科学中的重要性。随着技术的不断进步，进行全局比对的方法可能会变得更加复杂，从而允许对生命复杂性的更深入的见解。研究人员必须继续完善这些技术，以提高其准确性和适用性，确保全局比对在探索生物数据中仍然是一种重要工具。