intragenic

简明释义

英[ˌɪntrəˈdʒenɪk]美[ɪntrəˈdʒenɪk]

adj. [遗] 基因内的

英英释义

单词用法

同义词

反义词

例句

1.Conclusions No functional FANCA protein was found in these 3 cases of FA-A, and intragenic deletion, frame shift and splice site mutation were the major pathogenic mutations found in FANCA gene.

结论3例FA-A型患者均无功能性FANCA蛋白表达；基因缺失、移码突变和剪切位点突变是FANCA基因的主要失活方式。

2.The intragenic and extragenic recombination results in variation. Recombination also is involved in generation novel resistance specificities.

基因间和基因内重组导致了变异，也导致了新特异性抗病基因的产生。

3.It is necessary to detect the large intragenic MMR genes deletions in the molecular detection of HNPCC.

在分子遗传学检测中有必要开展MMR基因大片段缺失的检测。

4.Conclusions No functional FANCA protein was found in these 3 cases of FA-A, and intragenic deletion, frame shift and splice site mutation were the major pathogenic mutations found in FANCA gene.

结论3例FA-A型患者均无功能性FANCA蛋白表达；基因缺失、移码突变和剪切位点突变是FANCA基因的主要失活方式。

5.Methods: Using the polymerase chain reaction technique (PCRT), LOHs in 10 samples of hereditary ovarian cancer at intragenic loci were detected.

方法：应用多聚合酶链反应技术(PCRT)，对10份遗传性卵巢癌组织中BRCA1基因内部的D17S855微卫星位点进行LOH检测。

6.Both frameshift and missense mutations can be suppressed by intragenic suppressors.

两个突变发生在同一基因内的抑制，叫基因内抑制。

7.Both frameshift and missense mutations can be suppressed by intragenic suppressors.

移码突变和异义突变都能被基因内抑制基因所抑制。

8.The researchers discovered an intragenic 基因内的 mutation that affected the organism's ability to metabolize certain nutrients.

研究人员发现了一种影响生物体代谢某些营养素能力的intragenic 基因内的突变。

9.In the study of cancer, scientists focused on intragenic 基因内的 alterations that could lead to uncontrolled cell growth.

在癌症研究中，科学家们专注于可能导致细胞失控生长的intragenic 基因内的改变。

10.The intragenic 基因内的 sequences were analyzed to determine their role in gene expression regulation.

对intragenic 基因内的序列进行了分析，以确定它们在基因表达调控中的作用。

11.The findings suggest that intragenic 基因内的 changes can significantly impact phenotypic traits.

研究结果表明，intragenic 基因内的变化可以显著影响表型特征。

12.Understanding intragenic 基因内的 interactions is crucial for developing targeted therapies.

了解intragenic 基因内的相互作用对于开发靶向疗法至关重要。

作文

In recent years, the field of genetics has advanced tremendously, leading to new discoveries and applications that were once thought to be the realm of science fiction. One of the fascinating concepts arising from this research is the idea of intragenic mutations. These are changes that occur within a gene itself, as opposed to between genes or in non-coding regions of the DNA. Understanding intragenic alterations is essential for comprehending how genetic variations can influence traits and contribute to diseases.To illustrate this concept, consider a simple example: a gene responsible for producing a specific enzyme may undergo an intragenic mutation that alters its amino acid sequence. This change can affect the enzyme's structure and function, potentially leading to metabolic disorders. For instance, in certain cases of phenylketonuria (PKU), a single nucleotide change within the phenylalanine hydroxylase gene can result in a dysfunctional enzyme that cannot properly metabolize phenylalanine, causing severe health issues if not managed.The significance of intragenic mutations extends beyond individual health; they also play a crucial role in evolution. Natural selection acts on these mutations, favoring those that provide a survival advantage. Over time, beneficial intragenic changes can lead to the emergence of new traits within a population, contributing to the diversity of life we see today. For example, the development of antibiotic resistance in bacteria often stems from intragenic mutations that allow them to survive in the presence of drugs that would otherwise kill them.Moreover, the study of intragenic mutations has implications for genetic engineering and biotechnology. Scientists are increasingly able to edit genes with precision using techniques like CRISPR-Cas9. By understanding how intragenic changes affect gene function, researchers can design targeted interventions to correct genetic disorders or enhance desirable traits in crops and livestock. This has opened up exciting possibilities for improving food security and human health.However, the manipulation of intragenic sequences also raises ethical questions. As we gain the ability to alter the genetic makeup of organisms, we must consider the potential consequences of these changes. The risks of unintended effects from intragenic edits, such as off-target mutations or unforeseen interactions within the genome, must be carefully evaluated. Society must engage in discussions about the moral implications of genetic manipulation and establish guidelines to ensure responsible use of this powerful technology.In conclusion, intragenic mutations represent a vital aspect of genetics, influencing everything from individual health to evolutionary processes and biotechnological advancements. As our understanding of these mutations deepens, we unlock the potential to address complex challenges in medicine and agriculture. However, with this power comes the responsibility to tread carefully, considering both the benefits and the ethical dilemmas that arise from manipulating the very building blocks of life. The journey of exploring intragenic changes is just beginning, and it promises to shape the future of science and society in profound ways.

近年来，遗传学领域取得了巨大的进展，导致了一些曾被认为是科幻领域的新发现和应用。其中一个引人入胜的概念是intragenic突变的思想。这些变化发生在基因内部，而不是基因之间或DNA的非编码区域。理解intragenic改变对于理解遗传变异如何影响性状并导致疾病至关重要。为了说明这一概念，考虑一个简单的例子：负责产生特定酶的基因可能会经历intragenic突变，从而改变其氨基酸序列。这种变化可能会影响酶的结构和功能，潜在地导致代谢紊乱。例如，在某些苯丙酮尿症（PKU）病例中，苯丙氨酸羟化酶基因内的单个核苷酸变化可能导致功能失常的酶，无法正确代谢苯丙氨酸，如果不加以管理，会造成严重的健康问题。intragenic突变的重要性不仅限于个人健康；它们在进化中也发挥着关键作用。自然选择对这些突变施加影响，青睐那些提供生存优势的突变。随着时间的推移，有益的intragenic变化可以导致种群中新性状的出现，促进我们今天所看到的生命的多样性。例如，细菌中的抗生素耐药性的发展通常源于intragenic突变，使它们能够在本应杀死它们的药物存在下生存。此外，研究intragenic突变对基因工程和生物技术也有重要意义。科学家们越来越能够使用CRISPR-Cas9等技术精确编辑基因。通过理解intragenic变化如何影响基因功能，研究人员可以设计针对性的干预措施，以纠正遗传疾病或增强农作物和家畜的理想性状。这为改善粮食安全和人类健康开辟了令人兴奋的可能性。然而，操纵intragenic序列也引发了伦理问题。随着我们获得改变生物体遗传构成的能力，我们必须考虑这些变化的潜在后果。来自intragenic编辑的意外效应风险，例如脱靶突变或基因组内未预见的相互作用，必须仔细评估。社会必须参与关于基因操纵的道德影响的讨论，并建立指导方针，以确保负责任地使用这一强大技术。总之，intragenic突变代表遗传学的一个重要方面，影响从个人健康到进化过程以及生物技术进步的一切。随着我们对这些突变的理解加深，我们打开了解决医学和农业复杂挑战的潜力。然而，伴随这种力量而来的是责任，我们必须谨慎行事，考虑操纵生命基本构建块所带来的好处和伦理困境。探索intragenic变化的旅程才刚刚开始，它承诺将在深远的方式上塑造科学和社会的未来。