haptoglobin

简明释义

英[ˌhæptəˈɡləʊbɪn]美[ˈhæptəˌɡloʊbɪn]

n. [生化] 触珠蛋白；[生化] 结合珠蛋白

英英释义

单词用法

同义词

反义词

例句

1.Based on our observations, the subunit structures of haptoglobin protein conjugates are largely consistent with the known model.

根据我们的发现，血红素结合蛋白同原体的次单元结构大部分和已知模型相符合。

2.In intravascular hemolytic anemia, more RBC are destroyed in the circulation (hemoglobinemia) than can be bound to haptoglobin.

当发生血管内溶血性贫血，更多红细胞在血液循环(血红蛋白血症)被破坏以至于超出肝球蛋白质的结合能力。

3.There are several versions of the haptoglobin gene.

有几种版本的结合珠蛋白基因。

4.This is quickly converted to Hgb dimers that bind to haptoglobin and are transported to the liver, where they are metabolized in the same manner as products from RBC removed by phagocytosis.

然后迅速转化为血红蛋白二聚体与肝球蛋白质结合，并运送到肝脏经吞噬作用除去。

5.Conclusion The haptoglobin may be a potential biomarker for monitoring prognosis in patients with leukemia treated by stem cell transplantation.

结论触珠蛋白有可能成为白血病干细胞移植治疗疗效评价及疗程监测的标志物。

6.This is quickly converted to Hgb dimers that bind to haptoglobin and are transported to the liver, where they are metabolized in the same manner as products from RBC removed by phagocytosis.

然后迅速转化为血红蛋白二聚体与肝球蛋白质结合，并运送到肝脏经吞噬作用除去。

7.A simpler method for preparing haptoglobin from the waste residue of Rivanol - ammonium sulphate fractionation of human serum during the production of human immunoglobulin is described.

本文报告了从利凡诺-硫酸铵法生产人血免疫球蛋白的废渣中，制备结合珠蛋白的一种简易方法。

8.The doctor ordered a blood test to measure the level of haptoglobin, which helps assess hemolysis.

医生要求进行血液测试以测量结合球蛋白的水平，这有助于评估溶血。

9.In cases of liver disease, haptoglobin levels may be significantly altered.

在肝病病例中，结合球蛋白水平可能会显著改变。

10.A low haptoglobin level can indicate a possible hemolytic anemia.

低结合球蛋白水平可能表明存在潜在的溶血性贫血。

11.The presence of free hemoglobin in the blood can lead to decreased haptoglobin levels.

血液中游离的血红蛋白的存在可以导致结合球蛋白水平降低。

12.Monitoring haptoglobin is crucial for patients undergoing treatment for autoimmune disorders.

监测结合球蛋白对接受自身免疫性疾病治疗的患者至关重要。

作文

Haptoglobin is a protein that plays a crucial role in the human body, particularly in the context of hemoglobin metabolism. When red blood cells are destroyed, they release hemoglobin into the bloodstream. This free hemoglobin can be harmful because it can lead to oxidative damage and kidney injury. To mitigate these risks, the body utilizes a protein called haptoglobin (结合蛋白), which binds to free hemoglobin. This binding process not only helps to prevent the potential damage caused by free hemoglobin but also facilitates its removal from the bloodstream. Once haptoglobin binds to hemoglobin, the complex is recognized and taken up by the liver, where it can be processed and eliminated safely.The importance of haptoglobin extends beyond just protecting the body from the harmful effects of hemoglobin. It is also a significant marker for various medical conditions. For instance, low levels of haptoglobin in the blood can indicate hemolysis, a condition where red blood cells are destroyed faster than they can be produced. This can occur in several disorders, including autoimmune diseases, certain infections, and reactions to medications. On the other hand, elevated levels of haptoglobin may suggest inflammation or tissue damage, as the liver produces more of this protein in response to inflammatory cytokines.In clinical settings, measuring haptoglobin levels can provide valuable insights into a patient's health status. For example, when a physician suspects hemolytic anemia, they may order a haptoglobin test alongside other tests to confirm the diagnosis. The results can guide treatment decisions and help monitor the effectiveness of interventions. Moreover, understanding the dynamics of haptoglobin can aid researchers in developing new therapies for conditions associated with hemolysis and inflammation.Interestingly, the genetic variations in the haptoglobin gene can influence an individual's susceptibility to certain diseases. Studies have shown that different haptoglobin phenotypes may affect how the body responds to oxidative stress and inflammation. For instance, individuals with the Hp2-2 genotype might experience more severe outcomes in conditions like sepsis compared to those with other genotypes. This highlights the potential of haptoglobin not only as a biomarker but also as a target for personalized medicine, where treatments could be tailored based on a person's genetic makeup.In conclusion, haptoglobin is much more than just a simple protein; it is a vital component of our body's defense mechanisms against oxidative stress and inflammation. Its role in binding free hemoglobin protects our tissues from damage and aids in the recovery process following hemolysis. Furthermore, the measurement of haptoglobin levels can provide critical information about a person's health, guiding diagnostic and therapeutic strategies. As research continues to unveil the complexities of haptoglobin and its implications in various diseases, it will undoubtedly remain a focal point in both clinical practice and scientific investigation.

结合蛋白是人体中一种重要的蛋白质，尤其是在血红蛋白代谢的背景下。当红细胞被破坏时，它们会将血红蛋白释放到血液中。这种游离的血红蛋白可能是有害的，因为它可能导致氧化损伤和肾损伤。为了减轻这些风险，身体利用一种名为结合蛋白（haptoglobin）的蛋白质，它可以与游离的血红蛋白结合。这一结合过程不仅有助于防止游离血红蛋白造成的潜在损害，还促进了其从血液中的去除。一旦结合蛋白与血红蛋白结合，形成的复合物就会被肝脏识别并摄取，在那里可以安全地进行处理和排除。结合蛋白的重要性不仅仅体现在保护身体免受血红蛋白的有害影响上。它还是多种医学条件的重要标志。例如，血液中低水平的结合蛋白可能表明溶血，即红细胞被破坏的速度超过了它们的产生速度。这种情况可能发生在几种疾病中，包括自身免疫性疾病、某些感染和对药物的反应。另一方面，升高的结合蛋白水平可能暗示炎症或组织损伤，因为肝脏在炎症细胞因子的刺激下产生更多这种蛋白质。在临床环境中，测量结合蛋白水平可以提供有关患者健康状况的宝贵见解。例如，当医生怀疑溶血性贫血时，他们可能会在确认诊断时要求进行结合蛋白测试。这些结果可以指导治疗决策，并帮助监测干预措施的有效性。此外，了解结合蛋白的动态变化可以帮助研究人员开发新的疗法，以应对与溶血和炎症相关的疾病。有趣的是，结合蛋白基因的遗传变异可能影响个体对某些疾病的易感性。研究表明，不同的结合蛋白表型可能影响身体对氧化压力和炎症的反应。例如，Hp2-2基因型的个体在脓毒症等疾病中可能经历更严重的结果，而与其他基因型相比。这突显了结合蛋白作为生物标志物的潜力，也作为个性化医学的目标，治疗可以根据个人的基因组成进行调整。总之，结合蛋白不仅仅是一种简单的蛋白质；它是我们身体抵御氧化压力和炎症的重要组成部分。它在结合游离血红蛋白方面的作用保护我们的组织免受损害，并有助于在溶血后恢复过程。此外，测量结合蛋白水平可以提供有关一个人健康状况的关键信息，从而指导诊断和治疗策略。随着研究继续揭示结合蛋白的复杂性及其在各种疾病中的影响，它无疑将继续成为临床实践和科学研究的焦点。