paracrine

简明释义

英[/ˈpærəˌkraɪn/]美[/ˈpærəˌkraɪn/]

n. [生理] 旁分泌；副分泌；旁泌性

英英释义

单词用法

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例句

1.Paracrine signaling between these intimately associated cells also regulates the process of germ cell death.

细胞之间的旁分泌信号转导亦调节着生精细胞凋亡的过程。

2.The resulting PGE2 operates in an autocrine manner, cooperating with ongoing paracrine IL-1 signaling, to induce expression of a group of cytokines by the MSCs.

PGE2自分泌的方式运作配合旁分泌的IL - 1信号诱发间充质干细胞大量细胞因子的表达。

3.Conclusion: It was suggested that MMP-2 expression is increased by paracrine stimulation mediated by soluble factors originated from oral CAFs and MMP-9 expression requires direct cell-cell contact.

结论：MMP - 2表达增加可能受到源自口腔癌相关成纤维细胞可溶性因子的旁分泌介导，而MMP - 9表达可能需要口腔癌细胞与癌相关成纤维细胞的直接接触。

4.Cytokines are polypeptides, and mediate cellular responses through autocrine and paracrine.

细胞因子是一类小分子多肽，通过自分泌和旁分泌传递细胞应答。

5.Chinese Herbs may enhance expression of HB-EGF on trophoblast through autocrine and paracrine role, and may enhance proliferation, invasion and tolerance anoxia of trophoblast.

中药可能通过自分泌或旁分泌增加滋养细胞HB - EGF表达，增强滋养细胞的增殖及侵入和对缺氧的耐受。

6.Some herbal medicine may stimulate the release of angiogenesis factors and a paracrine on the surrounding ischemic tissue, thereby enhancing the local ang...

一些中药也可通过刺激心肌缺血区各种血管生成因子和旁分泌达到促进血管生长的目标。

7.Some growth factors operate via paracrine signaling to stimulate tissue repair.

一些生长因子通过旁分泌信号刺激组织修复。

8.The paracrine factors released by immune cells can influence neighboring cells during an inflammatory response.

免疫细胞释放的旁分泌因子可以在炎症反应中影响邻近细胞。

9.The interaction between neurons often involves paracrine signaling to modulate synaptic strength.

神经元之间的相互作用通常涉及旁分泌信号以调节突触强度。

10.The paracrine signaling system is crucial for cell communication in tissues.

该旁分泌信号系统对于组织中的细胞通信至关重要。

11.In the pancreas, insulin acts through a paracrine mechanism to regulate blood sugar levels.

在胰腺中，胰岛素通过旁分泌机制调节血糖水平。

作文

In the intricate world of cellular communication, various mechanisms ensure that cells can coordinate their functions effectively. One such mechanism is known as paracrine signaling. This process involves the release of signaling molecules by a cell, which then act on nearby target cells within the same tissue. Unlike endocrine signaling, where hormones are released into the bloodstream to affect distant organs, paracrine signaling allows for localized and rapid responses, making it crucial for many physiological processes.The significance of paracrine signaling can be observed in numerous biological contexts. For example, during the immune response, certain immune cells release cytokines, which are a type of paracrine signaling molecule. These cytokines act on neighboring immune cells, enhancing their activity and promoting a swift response to pathogens. This localized communication ensures that the immune system can react quickly to infections, highlighting the importance of paracrine signaling in maintaining health.Another notable example of paracrine signaling occurs during the development of tissues. In embryonic development, cells often communicate through paracrine factors to guide the differentiation of stem cells into specific cell types. For instance, growth factors released by one group of cells can influence adjacent cells to develop into muscle or nerve cells. This precise regulation is vital for proper tissue formation and organ development.Furthermore, paracrine signaling plays a critical role in the regulation of various physiological functions, including wound healing and tissue repair. When an injury occurs, damaged cells release growth factors and other signaling molecules that act on surrounding cells to stimulate proliferation and migration. This coordinated effort helps to restore the integrity of the tissue, showcasing how paracrine signaling facilitates healing processes in the body.However, dysregulation of paracrine signaling can lead to pathological conditions. For instance, in cancer, tumor cells may exploit paracrine signaling to promote their own growth and survival while inhibiting the surrounding healthy cells. This aberrant communication can create a favorable microenvironment for tumors, allowing them to thrive and metastasize. Understanding the mechanisms of paracrine signaling in cancer biology is essential for developing targeted therapies that can disrupt these harmful interactions.In conclusion, paracrine signaling is a fundamental aspect of cellular communication that allows for localized and efficient responses among neighboring cells. Its role in immune responses, tissue development, and healing processes underscores its importance in maintaining homeostasis within the body. Conversely, when paracrine signaling becomes dysregulated, it can contribute to disease progression, particularly in cancer. As research continues to uncover the complexities of paracrine signaling pathways, it holds promise for advancing our understanding of various biological processes and developing innovative therapeutic strategies.

在细胞通信的复杂世界中，各种机制确保细胞能够有效地协调其功能。其中一种机制被称为旁分泌信号传递。这个过程涉及细胞释放信号分子，然后这些分子作用于同一组织内附近的靶细胞。与内分泌信号传递不同，后者是激素释放到血液中以影响远处器官，旁分泌信号传递允许局部和快速反应，使其在许多生理过程中至关重要。旁分泌信号传递的重要性可以在多个生物学背景中观察到。例如，在免疫反应期间，某些免疫细胞释放细胞因子，这是一种旁分泌信号分子。这些细胞因子作用于邻近的免疫细胞，增强它们的活性并促进对病原体的快速反应。这种局部通信确保免疫系统可以迅速对感染作出反应，突显了旁分泌信号传递在维持健康方面的重要性。另一个显著的旁分泌信号传递的例子发生在组织发育过程中。在胚胎发育过程中，细胞常常通过旁分泌因子进行通信，以指导干细胞向特定细胞类型的分化。例如，一组细胞释放的生长因子可以影响相邻细胞发育成肌肉或神经细胞。这种精确的调节对于适当的组织形成和器官发育至关重要。此外，旁分泌信号传递在调节各种生理功能方面也发挥着关键作用，包括创伤愈合和组织修复。当发生损伤时，受损细胞释放生长因子和其他信号分子，这些分子作用于周围细胞以刺激增殖和迁移。这种协调的努力有助于恢复组织的完整性，展示了旁分泌信号传递如何促进身体的愈合过程。然而，旁分泌信号传递的失调可能导致病理状况。例如，在癌症中，肿瘤细胞可能利用旁分泌信号传递来促进自身的生长和存活，同时抑制周围的健康细胞。这种异常的通信可以为肿瘤创造一个有利的微环境，使它们能够繁荣和转移。了解旁分泌信号传递在癌症生物学中的机制对开发能够破坏这些有害相互作用的靶向疗法至关重要。总之，旁分泌信号传递是细胞通信的一个基本方面，允许邻近细胞之间进行局部和有效的反应。它在免疫反应、组织发育和愈合过程中的作用凸显了其在维持身体稳态方面的重要性。相反，当旁分泌信号传递失调时，它可能会促成疾病进展，特别是在癌症中。随着研究继续揭示旁分泌信号传递通路的复杂性，它有望推进我们对各种生物过程的理解，并开发创新的治疗策略。