immunotoxin

简明释义

英[ˌɪmjʊnəʊˈtɒksɪn]美[ˌɪmjənoʊˈtɑːksɪn]

n. 抗毒素

英英释义

单词用法

同义词

反义词

例句

1.The preparation process of the immunotoxin plasmid includes the construction of the recombinant plasmid, the preparation of the recombinant transinfected engineering bacterium and other steps.

该免疫毒素质粒的制备方法包括重组质粒的构建、重组质粒转染的工程菌的制备等步骤。

2.Immunotoxin is a novel class of targeted agents in recent years, which is composed of toxin fragment and antibody or cytokine.

免疫毒素是近年来新兴的一种特异性靶向治疗药物，由毒素蛋白和载体两部分构成。

3.The development situation and application prospect of immunotoxin therapy in oral disease are reviewed in this paper.

本文主要综述了免疫毒素在口腔相关疾病生物治疗中应用的研究进展。

4.The preparation process of the immunotoxin plasmid includes the construction of the recombinant plasmid, the preparation of the recombinant transinfected engineering bacterium and other steps.

该免疫毒素质粒的制备方法包括重组质粒的构建、重组质粒转染的工程菌的制备等步骤。

5.Doctors are excited about the potential of immunotoxins 免疫毒素 to revolutionize cancer therapy.

医生们对免疫毒素 免疫毒素在癌症治疗中可能带来的革命性感到兴奋。

6.The clinical trial showed promising results for the immunotoxin 免疫毒素 in treating leukemia.

临床试验显示，该免疫毒素 免疫毒素在治疗白血病方面有良好的效果。

7.Scientists are investigating how immunotoxins 免疫毒素 can be used to treat autoimmune diseases.

科学家们正在研究如何利用免疫毒素 免疫毒素来治疗自身免疫疾病。

8.The use of immunotoxins 免疫毒素 in targeted therapy reduces side effects compared to traditional chemotherapy.

与传统化疗相比，使用免疫毒素 免疫毒素的靶向治疗减少了副作用。

9.Researchers are developing a new type of immunotoxin 免疫毒素 that targets cancer cells more effectively.

研究人员正在开发一种新型的免疫毒素 免疫毒素，能够更有效地靶向癌细胞。

作文

In the realm of modern medicine, the development of targeted therapies has revolutionized the treatment of various diseases, particularly cancer. One such innovative approach is the use of immunotoxin, a powerful tool that combines the specificity of antibodies with the cytotoxic effects of toxins. This unique combination allows for precise targeting of cancerous cells while minimizing damage to healthy tissues. The concept of immunotoxin is rooted in the principles of immunology and biochemistry, where antibodies are engineered to deliver lethal agents directly to malignant cells.The mechanism of action of immunotoxin involves the binding of an antibody to a specific antigen present on the surface of cancer cells. Once bound, the immunotoxin is internalized by the cell, leading to the release of the attached toxin, which can induce apoptosis or programmed cell death. This targeted approach not only enhances the efficacy of the treatment but also reduces the side effects commonly associated with traditional chemotherapy.One of the most notable examples of immunotoxin therapy is the use of ricin A-chain conjugated to monoclonal antibodies. Ricin, derived from the castor bean, is a potent toxin that inhibits protein synthesis, leading to cell death. By linking this toxin to antibodies that specifically target tumor-associated antigens, researchers have created a formidable weapon against cancer. Clinical trials have shown promising results, demonstrating significant tumor regression in patients treated with immunotoxin therapies.Moreover, immunotoxin therapies are not limited to treating solid tumors; they have also been explored for hematological malignancies. For instance, immunotoxin targeting CD22 has been utilized in the treatment of B-cell malignancies, showcasing its versatility and potential in various cancer types.Despite the advancements in immunotoxin research, several challenges remain. One major hurdle is the potential for the development of resistance, as cancer cells may alter their surface antigens to evade detection by the immunotoxin. Furthermore, the production of immunotoxin requires sophisticated biotechnological processes, which can be costly and time-consuming. Ensuring the stability and safety of these therapeutic agents is also crucial, as any adverse effects could undermine their clinical utility.In conclusion, immunotoxin represents a promising frontier in cancer therapy, offering a more targeted and effective approach to treatment. As research continues to evolve, it is essential to address the existing challenges and optimize the design of immunotoxin therapies. The potential to improve patient outcomes and reduce the burden of cancer underscores the importance of this innovative strategy in the ongoing battle against one of humanity's most formidable foes. With continued investment and exploration in this field, immunotoxin could pave the way for a new era in personalized medicine, providing hope for countless patients worldwide.

在现代医学领域，靶向疗法的发展彻底改变了各种疾病的治疗，特别是癌症。一种创新的方法是使用免疫毒素，这是一种强大的工具，将抗体的特异性与毒素的细胞毒性效应结合在一起。这种独特的组合使得能够精确靶向癌细胞，同时最小化对健康组织的损害。免疫毒素的概念根植于免疫学和生物化学的原理中，其中抗体被设计用于直接将致命剂送达恶性细胞。免疫毒素的作用机制涉及抗体与癌细胞表面特定抗原的结合。一旦结合，免疫毒素就会被细胞内化，导致附着的毒素释放，从而诱导细胞凋亡或程序性细胞死亡。这种靶向方法不仅提高了治疗的有效性，还减少了传统化疗常见的副作用。最著名的免疫毒素疗法之一是将蓖麻毒素A链与单克隆抗体结合使用。蓖麻毒素源自蓖麻种子，是一种强效毒素，能够抑制蛋白质合成，导致细胞死亡。通过将这种毒素与特异性靶向肿瘤相关抗原的抗体连接，研究人员创造了一种强大的癌症武器。临床试验显示出令人鼓舞的结果，证明接受免疫毒素治疗的患者肿瘤显著缩小。此外，免疫毒素疗法并不限于治疗实体肿瘤；它们也被探索用于血液恶性肿瘤。例如，靶向CD22的免疫毒素已在B细胞恶性肿瘤的治疗中得到应用，展示了其在各种癌症类型中的多样性和潜力。尽管免疫毒素研究取得了进展，但仍然存在几个挑战。一个主要障碍是耐药性的产生，因为癌细胞可能会改变其表面抗原以逃避免疫毒素的检测。此外，生产免疫毒素需要复杂的生物技术过程，这可能成本高昂且耗时。确保这些治疗剂的稳定性和安全性也至关重要，因为任何不良反应都可能削弱其临床效用。总之，免疫毒素代表了癌症治疗中的一个有前景的前沿，为治疗提供了更为靶向和有效的方法。随着研究的不断发展，解决现有挑战并优化免疫毒素疗法的设计至关重要。改善患者预后和减轻癌症负担的潜力突显了这一创新策略在与人类最可怕的敌人之一的持续斗争中的重要性。随着在这一领域的持续投资和探索，免疫毒素可能为个性化医学的新纪元铺平道路，为全球无数患者提供希望。