stereochemical

简明释义

英[/ˌstɛrɪəʊˈkɛmɪkəl/]美[/ˌstɛriəˈkɛmɪkəl/]

adj. 立体化学的

英英释义

单词用法

同义词

反义词

例句

1.Moreover, the parameters affected the stereochemical outcome of the reaction, such as solvent, substrate design, immobilization and directed evolution, were more understanding.

另外，人们对影响反应生成的立体化学产物的参数(如溶剂、底物设计、固定化、定向进化等)有了进一步的了解。

2.A study to determine the factors influencing the stereochemical results has been reported.

有关测定这类立体化学的影响因素的研究，也有报导。

3.The binding geometry determined by interaction of the residues and bases in recognition area is indicated in the stereochemical chart.

决定氨基酸残基和碱基相互关系的结合几何图形表示为立体化学图，它表明了识别的特异性。

4.Biocatalysis has become one of the most promising and effective methods in the asymmetric synthesis for its outstanding stereochemical specificity.

生物催化因其高效和高度的立体选择性，成为手性合成最重要的方法之一。

5.Moreover, the parameters affected the stereochemical outcome of the reaction, such as solvent, substrate design, immobilization and directed evolution, were more understanding.

另外，人们对影响反应生成的立体化学产物的参数(如溶剂、底物设计、固定化、定向进化等)有了进一步的了解。

6.Because of its unique stereochemical properties, the axially dissymmetric biaryls have been studied with great interesting since 1970s.

轴不对称联芳香化合物具有独特的立体化学性质，从七十年代以来受到有机化学家的重视。

7.Understanding the stereochemical 立体化学的 configuration is crucial for drug design.

理解立体化学的构型对于药物设计至关重要。

8.The stereochemical 立体化学的 features of the molecule were analyzed using NMR spectroscopy.

该分子的立体化学的特征通过核磁共振光谱法进行了分析。

9.In organic chemistry, stereochemical 立体化学的 considerations are essential for predicting reaction outcomes.

在有机化学中，立体化学的考虑对于预测反应结果至关重要。

10.The stereochemical 立体化学的 arrangement of atoms can affect the physical properties of a molecule.

原子的立体化学的排列可以影响分子的物理性质。

11.The study of the compound's stereochemical 立体化学的 properties revealed unexpected reactivity.

对该化合物的立体化学的性质的研究揭示了意想不到的反应性。

作文

In the field of chemistry, the term stereochemical refers to the study of the spatial arrangement of atoms within molecules and how this arrangement affects their chemical properties and reactions. Understanding stereochemical principles is crucial for chemists, especially when it comes to the synthesis of complex organic compounds. The three-dimensional structure of a molecule can significantly influence its reactivity, biological activity, and overall function. For instance, consider the case of chiral molecules, which are non-superimposable mirror images of each other. These molecules exhibit different stereochemical configurations, leading to distinct interactions with biological systems. A classic example is the drug thalidomide, which was marketed as a sedative in the 1950s. One enantiomer of thalidomide had the desired sedative effects, while the other caused severe birth defects. This tragic outcome highlighted the importance of stereochemical considerations in drug development. Moreover, the concept of stereochemical is not limited to organic chemistry; it also extends to inorganic and physical chemistry. In inorganic complexes, the arrangement of ligands around a central metal atom can lead to different geometrical isomers, impacting the compound's color, magnetic properties, and reactivity. For example, octahedral complexes can exist in various stereochemical forms, such as facial and meridional isomers, which have different properties despite having the same molecular formula. In addition to its implications in synthesis and reactivity, stereochemical analysis is vital in the field of biochemistry. Enzymes, which are biological catalysts, often exhibit high specificity for certain stereochemical configurations of substrates. This specificity is due to the precise shape and charge distribution of the enzyme's active site, which allows it to interact favorably with only certain isomers. Consequently, understanding the stereochemical nature of substrates can aid in the design of more effective drugs and biocatalysts. Furthermore, advancements in analytical techniques, such as nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, have allowed chemists to determine the stereochemical configurations of molecules with greater accuracy. These techniques provide insights into the three-dimensional structures of compounds, enabling researchers to elucidate reaction mechanisms and predict the outcomes of chemical reactions. In conclusion, the study of stereochemical aspects of molecules is fundamental to many areas of chemistry and biochemistry. It plays a critical role in the understanding of molecular behavior, the development of new drugs, and the design of catalysts. As research continues to evolve, the importance of stereochemical considerations will only grow, paving the way for innovations in various scientific fields. Chemists must remain vigilant in their understanding of stereochemical principles to harness the full potential of molecular science and improve our quality of life.

在化学领域，术语立体化学指的是研究分子中原子的空间排列以及这种排列如何影响它们的化学性质和反应。理解立体化学原理对化学家至关重要，尤其是在合成复杂有机化合物时。分子的三维结构可以显著影响其反应性、生物活性和整体功能。例如，考虑手性分子的情况，这些分子是彼此不可叠加的镜像。这些分子表现出不同的立体化学构型，导致与生物系统的不同相互作用。一个经典的例子是药物沙利度胺，它在1950年代作为镇静剂上市。沙利度胺的一个对映体具有所需的镇静效果，而另一个则导致严重的出生缺陷。这一悲惨后果突显了在药物开发中考虑立体化学的重要性。此外，立体化学的概念不仅限于有机化学；它还扩展到无机和物理化学。在无机络合物中，配体围绕中心金属原子的排列可以导致不同的几何异构体，从而影响化合物的颜色、磁性和反应性。例如，八面体络合物可以存在于各种立体化学形式中，如面向异构体和经度异构体，尽管它们具有相同的分子式，但却具有不同的性质。除了在合成和反应性方面的影响外，立体化学分析在生物化学领域也至关重要。酶，即生物催化剂，通常对某些立体化学构型的底物表现出高度特异性。这种特异性是由于酶活性位点的精确形状和电荷分布，使其只能与某些异构体进行有利的相互作用。因此，理解底物的立体化学特性可以帮助设计更有效的药物和生物催化剂。此外，核磁共振（NMR）光谱和X射线晶体学等分析技术的进步使化学家能够更准确地确定分子的立体化学构型。这些技术提供了对化合物三维结构的洞察，使研究人员能够阐明反应机制并预测化学反应的结果。总之，研究分子的立体化学方面是化学和生物化学许多领域的基础。它在理解分子行为、新药开发和催化剂设计中发挥着关键作用。随着研究的不断发展，立体化学考虑的重要性将只会增加，为各个科学领域的创新铺平道路。化学家必须保持对立体化学原理的敏锐理解，以充分利用分子科学的潜力，提高我们的生活质量。