chemokines

简明释义

英[/ˈkiːmoʊkaɪnz/]美[/ˈkiːmoʊkaɪnz/]

n. 趋化因子；趋化激素（chemokine 的复数形式）

英英释义

单词用法

同义词

反义词

例句

1.A recent clinical study in Vietnam showed that H5N1 patients had higher levels of cytokines and chemokines-molecular messengers involved in inflammation-than patients with seasonal flu had.

最近越南的临床研究报道，H5N1感染病人比普通流感病毒感染产生更高水平的细胞因子和趋化因子——参与炎症的分子信使。

2.Targeted therapy that aims directly at chemokines and their receptors can ameliorate inflammatory damage, and can be a novel therapeutics for inflammatory bowel disease.

针对趋化因子及其受体的靶向治疗能减轻炎症损伤，可望成为一种新的炎症性肠病的治疗方法。

3.Therefore, the new theory and the technology about chemokines may provide some new ways for clinical treatment of certain diseases.

因此，有关趋化性细胞因子的新理论和技术可为临床治疗某些疾病提供了新思路。

4.It has been proved that chemokine receptor antagonists have ideal curative effects on the diseases related to chemokines, and some drugs have entered the clinical tests.

许多研究表明：趋化因子受体拮抗剂对各种与趋化因子相关的疾病具有较好的疗效，有些药物已经进入临床试验中。

5.Cytokines, Chemokines, and Growth Factors in ASD brain are found elevated, and the immune gene expression and the Interferon signaling pathway are found significantly different in the ASD.

研究发现自闭症患者大脑中的炎性细胞因子、趋化因子及生长因子是过表达的。而且自闭症患者的免疫基因表达和干扰信号通路也存在极大的差异。

6.It has been reported that a lot of cytokines and chemokines were involved in allergic inflammation. Antihistamines have inhibition effects on the migration and activation of inflammatory cells.

研究发现过敏炎症中有许多细胞因子和趋化因子参与，抗组胺药物对炎症细胞的迁移和激活有抑制作用。

7.The invention discloses an application of tetrandrine, which is used to prepare combined substances for inhibiting the expressions of chemokines and to control liver injury.

本发明公开了一种汉防己碱的用途，用于制备抑制趋化因子表达的组合物以及防治肝损伤。

8.It has been reported that a lot of cytokines and chemokines were involved in allergic inflammation. Antihistamines have inhibition effects on the migration and activation of inflammatory cells.

研究发现过敏炎症中有许多细胞因子和趋化因子参与，抗组胺药物对炎症细胞的迁移和激活有抑制作用。

9.Conclusion Upregulated chemokines were associated with macrophage recruitment and destruction of islet xenografts.

结论：趋化因子的上调与巨噬细胞的聚集、胰岛移植物的破坏有关。

10.The release of chemokines triggers an inflammatory response in the body.

释放的化学趋化因子在体内引发炎症反应。

11.Certain diseases are associated with an abnormal production of chemokines.

某些疾病与化学趋化因子的异常产生有关。

12.The interaction between chemokines and their receptors is crucial for immune function.

化学趋化因子与其受体之间的相互作用对免疫功能至关重要。

13.Therapeutic agents targeting chemokines could be effective in treating chronic inflammation.

针对化学趋化因子的治疗药物可能有效治疗慢性炎症。

14.Researchers are studying how chemokines can influence immune cell migration.

研究人员正在研究化学趋化因子如何影响免疫细胞的迁移。

作文

In recent years, the field of immunology has made significant strides in understanding the complex interactions between different components of the immune system. One area that has garnered much attention is the role of chemokines, which are small signaling proteins that direct the movement of immune cells throughout the body. These molecules play a crucial role in the inflammatory response and are essential for maintaining homeostasis within the immune system. Chemokines (化学趋化因子) serve as navigational cues for immune cells, guiding them to sites of infection or injury where they are needed most.The discovery of chemokines dates back to the early 1990s when researchers began to identify specific proteins that could influence the migration of leukocytes, or white blood cells. These proteins are categorized into four main families based on their structure and the receptors they bind to. The two primary types of chemokines are CC-chemokines and CXC-chemokines, which differ in the arrangement of their cysteine residues. Each type of chemokine interacts with its corresponding receptor on the surface of immune cells, triggering a cascade of intracellular signals that ultimately lead to cell movement.The importance of chemokines extends beyond just directing immune cell traffic. They are also involved in various physiological processes, including tissue repair, angiogenesis, and the development of lymphoid organs. For instance, during an infection, chemokines are released by damaged tissues and activated immune cells, creating a gradient that attracts neutrophils and monocytes to the site of inflammation. This recruitment is vital for the clearance of pathogens and the initiation of the healing process.Moreover, chemokines have been implicated in several diseases, particularly those characterized by chronic inflammation, such as autoimmune disorders and cancer. In these conditions, the dysregulation of chemokines can lead to excessive immune cell accumulation and tissue damage. For example, in rheumatoid arthritis, elevated levels of certain chemokines contribute to the recruitment of inflammatory cells to the joints, exacerbating the disease.Researchers are now exploring therapeutic strategies that target chemokines and their receptors to modulate immune responses. By inhibiting specific chemokines, it may be possible to reduce inflammation and improve outcomes in patients with chronic inflammatory diseases. Conversely, enhancing chemokines could be beneficial in situations where a robust immune response is needed, such as in cancer immunotherapy.In conclusion, chemokines are vital players in the immune system, orchestrating the movement and function of immune cells. Their ability to guide cells to sites of infection and inflammation underscores their significance in both health and disease. As our understanding of chemokines continues to evolve, it holds promise for the development of novel therapeutic approaches that harness the power of the immune system to combat various diseases effectively.

近年来，免疫学领域在理解免疫系统不同组成部分之间复杂相互作用方面取得了重大进展。其中一个备受关注的领域是化学趋化因子（chemokines）的作用，这是一类小型信号蛋白，负责引导免疫细胞在体内的移动。这些分子在炎症反应中发挥着至关重要的作用，并且对维持免疫系统的稳态至关重要。化学趋化因子（chemokines）作为免疫细胞的导航线索，引导它们前往感染或损伤的部位，满足其需求。化学趋化因子（chemokines）的发现可以追溯到1990年代初，当时研究人员开始识别出能够影响白细胞（即免疫细胞）迁移的特定蛋白质。这些蛋白质根据其结构和结合的受体被分为四个主要家族。两种主要类型的化学趋化因子（chemokines）是CC-化学趋化因子（CC-chemokines）和CXC-化学趋化因子（CXC-chemokines），它们在半胱氨酸残基的排列上有所不同。每种类型的化学趋化因子（chemokines）与免疫细胞表面相应的受体相互作用，触发一系列细胞内信号，最终导致细胞运动。化学趋化因子（chemokines）的重要性不仅限于引导免疫细胞的交通。它们还参与多种生理过程，包括组织修复、血管生成和淋巴器官的发育。例如，在感染期间，受损组织和活化的免疫细胞释放化学趋化因子（chemokines），形成一个梯度，吸引中性粒细胞和单核细胞到达炎症部位。这种招募对于清除病原体和启动愈合过程至关重要。此外，化学趋化因子（chemokines）在几种疾病中也有涉及，特别是那些以慢性炎症为特征的疾病，如自身免疫疾病和癌症。在这些情况下，化学趋化因子（chemokines）的失调可能导致免疫细胞过度积聚和组织损伤。例如，在类风湿关节炎中，某些化学趋化因子（chemokines）的水平升高，促成炎症细胞向关节的招募，加重了疾病。研究人员现在正在探索针对化学趋化因子（chemokines）及其受体的治疗策略，以调节免疫反应。通过抑制特定的化学趋化因子（chemokines），可能有助于减少炎症并改善慢性炎症疾病患者的预后。相反，增强化学趋化因子（chemokines）可能在需要强烈免疫反应的情况下，如癌症免疫疗法中，带来好处。总之，化学趋化因子（chemokines）是免疫系统中的重要参与者，协调免疫细胞的运动和功能。它们引导细胞到达感染和炎症部位的能力突显了它们在健康和疾病中的重要性。随着我们对化学趋化因子（chemokines）理解的不断深入，这为开发利用免疫系统力量有效对抗各种疾病的新疗法带来了希望。