chondrogenesis

简明释义

英[ˌkɒndrəʊˈdʒenɪsɪs]美[kɑːndroʊˈdʒenɪsɪs]

n. [胚] 软骨形成

英英释义

单词用法

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例句

1.Abstract: Objective to discussion the feasibility of mixed culture muscle-derived stem cells and chondrocytes to chondrogenesis in vitro.

摘要：目的探讨肌源性干细胞与软骨细胞混和培养体外成软骨的可行性。

2.The bone healing and the chondrogenesis of the implant with the receptors were observed with X-ray, electron and optical microscopes 2, 4, 6 and 8 weeks after operation.

术后2,4,6,8周通过大体形态X线、光镜和电镜检查评判移植物与受床愈合及软骨生长情况。

3.The bone healing and the chondrogenesis of the implant with the receptors were observed with X-ray, electron and optical microscopes 2, 4, 6 and 8 weeks after operation.

术后2,4,6,8周通过大体形态X线、光镜和电镜检查评判移植物与受床愈合及软骨生长情况。

4.Articular chondrogenesis can be induced when DPB is covered with pedicle periosteum.

将带蒂骨膜包裹dpb后能诱发关节软骨生成。

5.Researchers are investigating how stem cells can be used to promote chondrogenesis in damaged cartilage.

研究人员正在调查干细胞如何用于促进受损软骨的软骨发生。

6.Defects in chondrogenesis can lead to various skeletal disorders.

在软骨发生中的缺陷可能导致各种骨骼疾病。

7.Understanding the mechanisms of chondrogenesis is crucial for developing effective treatments for osteoarthritis.

理解软骨发生的机制对开发有效的骨关节炎治疗至关重要。

8.The experiment demonstrated that certain biomaterials can enhance chondrogenesis in vitro.

实验表明，某些生物材料可以在体外增强软骨发生。

9.The study focused on the role of growth factors in enhancing chondrogenesis.

这项研究集中于生长因子在促进软骨发生中的作用。

作文

The process of development and formation of cartilage is known as chondrogenesis. This biological phenomenon plays a crucial role in the overall growth and development of an organism, particularly during the early stages of embryonic development. Cartilage is a flexible connective tissue found in various parts of the body, including joints, rib cage, ear, nose, bronchial tubes, and intervertebral discs. Understanding chondrogenesis is essential not only for developmental biology but also for medical applications, especially in regenerative medicine and orthopedics.During chondrogenesis, mesenchymal stem cells differentiate into chondrocytes, the cells responsible for cartilage formation. This differentiation process is influenced by various signaling pathways and growth factors, such as the Transforming Growth Factor-beta (TGF-β) and Bone Morphogenetic Proteins (BMPs). These factors guide the stem cells to commit to the chondrocytic lineage, leading to the production of extracellular matrix components like collagen and proteoglycans, which are vital for cartilage structure and function.The significance of chondrogenesis extends beyond mere cartilage formation. It is integral to the development of the skeletal system. For instance, endochondral ossification, a process where bone is formed from cartilage, relies heavily on the proper functioning of chondrogenesis. Any disruption in this process can lead to skeletal abnormalities or diseases, such as osteoarthritis, where the cartilage deteriorates over time, causing pain and loss of mobility.Research into chondrogenesis has implications for treating cartilage injuries and degenerative diseases. Scientists are exploring stem cell therapies that could potentially regenerate damaged cartilage. By harnessing the principles of chondrogenesis, researchers aim to develop techniques to repair or replace damaged cartilage in conditions like sports injuries or age-related degeneration. This approach could lead to innovative treatments that restore function and improve the quality of life for many individuals.Furthermore, understanding chondrogenesis can also contribute to advancements in tissue engineering. By creating scaffolds that mimic the natural extracellular matrix, scientists can promote the differentiation of stem cells into chondrocytes in vitro. This technology holds promise for developing bioengineered cartilage that could be used in surgical repairs or replacements.In summary, chondrogenesis is a fundamental biological process that not only contributes to cartilage formation but also plays a pivotal role in skeletal development and regeneration. Its study is vital for advancing our knowledge in developmental biology, enhancing therapeutic strategies for cartilage repair, and improving the outcomes for patients with cartilage-related disorders. As research continues to evolve, the potential applications of chondrogenesis in medicine and biotechnology are vast, paving the way for innovative solutions to complex health issues.

软骨发育和形成的过程被称为chondrogenesis。这一生物现象在有机体的整体生长和发育中起着至关重要的作用，特别是在胚胎发育的早期阶段。软骨是一种柔韧的结缔组织，存在于身体的多个部位，包括关节、肋骨、耳朵、鼻子、支气管和椎间盘。理解chondrogenesis不仅对发育生物学至关重要，而且对医学应用，尤其是再生医学和骨科也具有重要意义。在chondrogenesis过程中，间充质干细胞分化为软骨细胞，这些细胞负责软骨的形成。这一分化过程受到多种信号通路和生长因子的影响，如转化生长因子-β（TGF-β）和骨形态发生蛋白（BMPs）。这些因子引导干细胞承诺于软骨细胞谱系，导致细胞外基质成分如胶原蛋白和蛋白聚糖的产生，这对于软骨的结构和功能至关重要。chondrogenesis的重要性超出了单纯的软骨形成。它对骨骼系统的发育至关重要。例如，内软骨骨化是一个从软骨形成骨骼的过程，这在很大程度上依赖于chondrogenesis的正常功能。任何这一过程的干扰都可能导致骨骼异常或疾病，如骨关节炎，软骨随着时间的推移而退化，导致疼痛和活动能力丧失。对chondrogenesis的研究对治疗软骨损伤和退行性疾病具有重要意义。科学家们正在探索干细胞疗法，可能再生受损的软骨。通过利用chondrogenesis的原理，研究人员旨在开发技术来修复或替换在运动损伤或年龄相关退化中受损的软骨。这种方法可能导致创新的治疗方案，恢复功能，提高许多人的生活质量。此外，理解chondrogenesis还可以促进组织工程的进步。通过创建模拟自然细胞外基质的支架，科学家们可以在体外促进干细胞向软骨细胞的分化。这项技术为开发可用于外科修复或替换的生物工程软骨提供了希望。总之，chondrogenesis是一个基本的生物过程，不仅有助于软骨形成，还在骨骼发育和再生中发挥着关键作用。其研究对推动我们在发育生物学方面的知识、增强软骨修复的治疗策略以及改善软骨相关疾病患者的结果至关重要。随着研究的不断发展，chondrogenesis在医学和生物技术中的潜在应用广泛，为复杂健康问题的创新解决方案铺平了道路。