prodrugs

简明释义

英[ˈprəʊdrʌɡz]美[ˈproʊdrʌɡz]

前药

英英释义

单词用法

同义词

反义词

例句

1.Recent progresses in the studies of macromolecular prodrugs are summarized on types of main chain of macromolecular.

按大分子主链分类，介绍了近年来大分子前药的研究进展。

2.The recent progress in low molecular, high molecular and couplet prodrugs of CPTs was reviewed in classified manner, provide a reference for the design of prodrugs of CPTs.

综述了喜树碱及其衍生物的小分子、大分子和轭合物前药的研究进展，为新型喜树碱前药的合理药物设计提供一定参考。

3.This review addresses the progress of the oral prodrugs in recent years, mainly including classical prodrug design and targeted prodrug design.

本文综述了近年来口服前药研究的进展，主要包括经典前药设计和靶向前药设计。

4.The present invention provides single chain antibody-directed polymeric prodrugs containing multifunctional linkers.

本发明提供单链抗体定向的包含多官能连接基的聚合物前药。

5.The design and synthesis of macromolecular prodrugs, choice of polymer carrier, active drug and linker are introduced.

对大分子前药的设计与合成，载体、活性药物和连接基的选择进行了论述。

6.The recent progress in low molecular, high molecular and couplet prodrugs of CPTs was reviewed in classified manner, provide a reference for the design of prodrugs of CPTs.

综述了喜树碱及其衍生物的小分子、大分子和轭合物前药的研究进展，为新型喜树碱前药的合理药物设计提供一定参考。

7.The research progress in the prodrugs of antiviral drugs are reviewed.

本文对抗病毒前体药物研究进展作介绍。

8.The compounds act as prodrugs of 2,6-diisopropylphenol and metabolize rapidly to Propofol thereby providing an alternative to the water-insoluble 2,6-diisopropylphenol.

所述化合物作为2，6- 二异丙基苯酚的前药迅速代谢成为异丙酚，从而为水不混溶的2，6-二异丙基苯酚提 供了可选方案。

9.Pharmaceutical compositions and single unit dosage forms of thalidomide and pharmaceutically acceptable prodrugs, salts, solvates, hydrates, or clathrates are disclosed.

本发明公开了沙利度胺及其药学可接受的前药、盐、溶剂化物、水合物或包合物的药物组合物和单一单位剂型。

10.The invention provides pharmaceutically acceptable esters, salts, and prodrugs thereof.

本发明提供了药学可接受的酯类、盐类及其前体药物。

11.The use of prodrugs 前药 can help reduce side effects by targeting specific areas of the body.

使用前药 prodrugs可以通过针对身体特定区域来减少副作用。

12.Researchers are studying new prodrugs 前药 that can be activated by enzymes in the liver.

研究人员正在研究新的前药 prodrugs，这些药物可以在肝脏中被酶激活。

13.The development of prodrugs 前药 has revolutionized the field of pharmacology.

前药prodrugs的发展彻底改变了药理学领域。

14.Many medications are designed as prodrugs 前药 to improve their absorption in the body.

许多药物被设计为前药 prodrugs以改善它们在体内的吸收。

15.Some cancer treatments utilize prodrugs 前药 to enhance drug delivery to tumor cells.

一些癌症治疗利用前药 prodrugs来增强药物对肿瘤细胞的输送。

作文

In the field of pharmacology, the term prodrugs refers to compounds that undergo biotransformation within the body to become an active drug. This concept is crucial for improving the efficacy and safety of medications. The primary purpose of using prodrugs is to enhance the absorption, distribution, metabolism, and excretion (ADME) properties of a drug. For example, certain drugs may be poorly soluble in water, making it difficult for them to be absorbed in the gastrointestinal tract. By converting these drugs into prodrugs, their solubility can be improved, allowing for better bioavailability.One of the most significant advantages of prodrugs is their ability to bypass certain metabolic pathways that might deactivate the drug before it reaches its target site. In some cases, the parent compound is converted into a less active form, which is then transformed into the active drug at the site of action. This selective activation can lead to fewer side effects and improved therapeutic outcomes. For instance, the well-known analgesic codeine is a prodrug; it is metabolized into morphine, which provides pain relief. Moreover, prodrugs can also help in overcoming barriers related to the blood-brain barrier (BBB). Some medications need to reach the central nervous system to be effective, but their molecular structure may prevent them from crossing this barrier. By designing prodrugs that can penetrate the BBB, researchers can develop more effective treatments for neurological conditions.However, the development of prodrugs is not without challenges. One major concern is the variability in individual responses to these compounds. Genetic differences among patients can affect the enzymes responsible for converting prodrugs into their active forms. This variability can lead to differences in efficacy and toxicity, making personalized medicine an essential aspect of treatment involving prodrugs. Additionally, the stability of prodrugs is another critical factor to consider. They must remain stable during storage and transit through the body until they reach the appropriate site for activation. If a prodrug degrades too quickly or not quickly enough, it may not provide the desired therapeutic effect.In conclusion, prodrugs represent a fascinating and valuable area of pharmaceutical research. Their ability to improve drug delivery, reduce side effects, and enhance therapeutic efficacy makes them an essential tool in modern medicine. As our understanding of drug metabolism and pharmacogenomics advances, the potential for developing new and innovative prodrugs will continue to grow, paving the way for more effective treatments for various diseases. It is vital for healthcare professionals and researchers to stay informed about the latest developments in this field to harness the full potential of prodrugs in clinical practice.

在药理学领域，术语prodrugs指的是在体内经过生物转化而成为活性药物的化合物。这个概念对于提高药物的疗效和安全性至关重要。使用prodrugs的主要目的是改善药物的吸收、分布、代谢和排泄（ADME）特性。例如，某些药物可能在水中的溶解度较差，这使得它们难以在胃肠道中被吸收。通过将这些药物转化为prodrugs，可以改善其溶解度，从而提高生物利用度。Prodrugs的一大显著优势是能够绕过某些代谢途径，这些途径可能会在药物到达其靶点之前使其失活。在某些情况下，母体化合物被转化为活性较低的形式，然后在作用部位转化为活性药物。这种选择性激活可以导致更少的副作用和改善的治疗效果。例如，著名的镇痛药可待因就是一种prodrug; 它在体内代谢成吗啡，从而提供疼痛缓解。此外，prodrugs还可以帮助克服与血脑屏障（BBB）相关的障碍。一些药物需要到达中枢神经系统才能有效，但其分子结构可能阻止它们穿越这一屏障。通过设计能够穿透BBB的prodrugs，研究人员可以开发出更有效的神经系统疾病治疗方法。然而，prodrugs的开发并非没有挑战。其中一个主要问题是个体对这些化合物反应的差异。患者之间的遗传差异可能会影响负责将prodrugs转化为其活性形式的酶。这种差异可能导致疗效和毒性的不同，使个性化医疗成为涉及prodrugs治疗的一个重要方面。此外，prodrugs的稳定性也是需要考虑的另一个关键因素。它们必须在储存和通过体内运输期间保持稳定，直到达到适当的激活位置。如果prodrug降解得太快或太慢，可能无法提供所需的治疗效果。总之，prodrugs代表了制药研究中的一个迷人且有价值的领域。它们改善药物递送、减少副作用和增强治疗效果的能力，使其成为现代医学中的一个重要工具。随着我们对药物代谢和药物基因组学理解的深入，开发新的创新prodrugs的潜力将继续增长，为各种疾病的更有效治疗铺平道路。医疗专业人员和研究人员必须及时了解该领域的最新进展，以充分利用prodrugs在临床实践中的潜力。