alloxan

简明释义

英[əˈlɒksən]美[əˈlɑːksən]

n. [有化] 阿脲，[有化] 四氧嘧啶

英英释义

单词用法

同义词

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例句

1.Method: Observe the influence of the granules on the blood sugar in normal mice, hyperglycemia mice induced by glucose or adrenalin and alloxan diabetes mice.

方法：观察对正常小鼠、葡萄糖高血糖小鼠、盐酸肾上腺素高血糖小鼠、四氧嘧啶糖尿病小鼠血糖含量影响。

2.Conclusion The oyster extract has a significantly protective effect on increasing of blood glucose in model mice induced by alloxan.

结论牡蛎提取物对四氧嘧啶所致小鼠血糖升高有显著的保护作用。

3.Diabetic mouse models were established by intravenous injection of alloxan tetrahydrate.

四氧嘧啶尾静脉注射制作糖尿病小鼠模型。

4.Objective:To study the effects of Jiangtang Mixture on blood glucose and blood lipid in normal mice and diabetic mice induced by alloxan.

目的：观察分析降糖合剂对正常小鼠血糖及四氧嘧啶糖尿病小鼠血糖、血脂的影响。

5.METHODS: The diabetic rat model was made with alloxan.

方法：利用四氧嘧啶复制糖尿病大鼠模型。

6.Objective: To study the preventive effect of flavoniods of Rosa roxburghii Tratt (FRRT) on diabetic mice induced by alloxan.

目的：研究刺梨黄酮对四氧嘧啶致实验性高血糖的预防作用。

7.In this paper we studied the effects of FSE (extracts of Forsythia suspense leaves) on oxidative lesion induced by alloxan in mice and evaluated the safety of its usage.

本文研究了连翘叶提取物(FSE)对小鼠氧化损伤的保护作用，并对其安全性进行初步评价。

8.After administering alloxan, the researchers observed a significant increase in blood glucose levels.

在给药阿洛克桑后，研究人员观察到血糖水平显著升高。

9.Researchers are studying the effects of alloxan on insulin secretion in diabetic rats.

研究人员正在研究阿洛克桑对糖尿病大鼠胰岛素分泌的影响。

10.The use of alloxan in laboratory settings allows for better understanding of diabetes mechanisms.

在实验室环境中使用阿洛克桑可以更好地理解糖尿病机制。

11.Scientists have found that alloxan can cause oxidative stress in pancreatic cells.

科学家发现阿洛克桑会导致胰腺细胞中的氧化应激。

12.The introduction of alloxan into the experiment helped to induce diabetes in the test subjects.

在实验中引入阿洛克桑有助于诱导测试对象的糖尿病。

作文

Alloxan is a compound that has garnered significant attention in the fields of biochemistry and pharmacology. It is primarily known for its role in diabetes research, particularly due to its ability to induce diabetes in experimental animal models. The chemical formula of alloxan is C4H2N2O4, and it is derived from uric acid. Researchers have found that when alloxan is administered to rodents, it selectively destroys insulin-producing beta cells in the pancreas, leading to hyperglycemia, which mimics the conditions of type 1 diabetes in humans.The mechanism by which alloxan exerts its effects involves the generation of reactive oxygen species (ROS). These ROS lead to oxidative stress, which ultimately results in cell death. This property of alloxan makes it an invaluable tool for scientists studying diabetes and the mechanisms underlying pancreatic beta-cell dysfunction. By understanding how alloxan induces diabetes, researchers can explore potential therapeutic strategies to protect beta cells or regenerate them in diabetic patients.Moreover, the use of alloxan extends beyond just inducing diabetes in animal models. It has also been utilized in various studies to investigate the protective effects of different compounds against oxidative stress. For example, researchers have tested antioxidants and other pharmacological agents to see if they can mitigate the damaging effects of alloxan on pancreatic cells. This research is crucial because it could lead to new treatments for diabetes, focusing on preserving or restoring the function of insulin-secreting cells.In addition to its implications in diabetes research, alloxan has also been studied for its potential role in cancer research. Some studies suggest that alloxan may have cytotoxic effects on certain cancer cell lines, making it a candidate for further investigation in oncology. Understanding the dual nature of alloxan—as both a tool for inducing diabetes and a potential agent in cancer therapy—highlights the complexity of its biological effects.Despite its usefulness in research, the application of alloxan in clinical settings is limited due to its toxic nature. The selective destruction of beta cells raises concerns about the safety and ethical implications of using alloxan in human subjects. Therefore, while it remains a critical compound in laboratory studies, more research is needed to fully understand its effects and potential applications in medicine.In conclusion, alloxan is a significant compound in the scientific community, particularly in the study of diabetes and oxidative stress. Its ability to induce diabetes in animal models has provided valuable insights into the disease's mechanisms and potential treatments. As research continues, the dual role of alloxan in both diabetes and cancer may open new avenues for therapeutic interventions, although caution must be exercised regarding its toxicity. The ongoing exploration of alloxan will undoubtedly contribute to our understanding of complex diseases and the development of innovative treatment strategies.

阿洛克萨是一种在生物化学和药理学领域引起了广泛关注的化合物。它主要因其在糖尿病研究中的作用而闻名，特别是由于它能够在实验动物模型中诱导糖尿病。阿洛克萨的化学式为C4H2N2O4，它是由尿酸衍生而来的。研究人员发现，当阿洛克萨被给予啮齿动物时，它选择性地破坏胰腺中的胰岛素产生β细胞，导致高血糖，这模仿了人类1型糖尿病的情况。阿洛克萨发挥作用的机制涉及活性氧物质（ROS）的生成。这些ROS导致氧化应激，最终导致细胞死亡。阿洛克萨的这一特性使其成为科学家研究糖尿病及胰腺β细胞功能障碍机制的重要工具。通过理解阿洛克萨如何诱导糖尿病，研究人员可以探索保护β细胞或在糖尿病患者中再生β细胞的潜在治疗策略。此外，阿洛克萨的应用不仅限于在动物模型中诱导糖尿病。它还被用于各种研究，以调查不同化合物对抗氧化应激的保护作用。例如，研究人员测试了抗氧化剂和其他药理剂，以查看它们是否可以减轻阿洛克萨对胰腺细胞的损害。这项研究至关重要，因为它可能导致针对糖尿病的新治疗方法，重点是保留或恢复胰岛素分泌细胞的功能。除了在糖尿病研究中的应用外，阿洛克萨也被研究其在癌症研究中的潜在作用。一些研究表明，阿洛克萨可能对某些癌细胞系具有细胞毒性效应，使其成为进一步研究肿瘤学的候选者。理解阿洛克萨的双重性质——作为诱导糖尿病的工具和潜在的癌症治疗剂——突显了其生物效应的复杂性。尽管在研究中十分有用，但由于其毒性，阿洛克萨在临床应用中的使用受到限制。选择性破坏β细胞引发了关于在人体受试者中使用阿洛克萨的安全性和伦理问题的担忧。因此，虽然它在实验室研究中仍然是一个关键化合物，但仍需进行更多研究以充分理解其影响和潜在的医学应用。总之，阿洛克萨在科学界中是一个重要的化合物，特别是在糖尿病和氧化应激的研究中。它在动物模型中诱导糖尿病的能力为我们提供了对该疾病机制和潜在治疗的宝贵见解。随着研究的继续，阿洛克萨在糖尿病和癌症中的双重作用可能会为治疗干预开辟新的途径，尽管必须对其毒性保持谨慎。对阿洛克萨的持续探索无疑将有助于我们理解复杂疾病和开发创新治疗策略。