diapedesis

简明释义

英[ˌdaɪəpəˈdiːsɪs]美[ˌdaɪəpɪˈdiːsɪs]

n. 血球渗出

复 数 d i a p e d e s e s

英英释义

单词用法

同义词

反义词

例句

1.Results Hemorrhagic shock and LPS challenge increased lung neutrophil infiltration and erythrocyte diapedesis.

结果在失血性休克和LPS刺激后肺出现明显的中性粒细胞浸润、红细胞渗出。

2.Results Hemorrhagic shock and LPS challenge increased lung neutrophil infiltration and erythrocyte diapedesis.

结果在失血性休克和LPS刺激后肺出现明显的中性粒细胞浸润、红细胞渗出。

3.In a laboratory experiment, scientists induced diapedesis (渗出) in cultured endothelial cells to study their behavior under stress.

在一项实验室实验中，科学家们诱导培养的内皮细胞发生diapedesis（渗出）以研究其在压力下的行为。

4.The process of diapedesis (渗出) is crucial for immune surveillance as it allows leukocytes to migrate towards sites of infection.

diapedesis（渗出）的过程对于免疫监视至关重要，因为它允许白血球向感染部位迁移。

5.During an inflammatory response, white blood cells undergo diapedesis (渗出) to exit the bloodstream and reach the affected tissues.

在炎症反应中，白血球经历diapedesis（渗出）以离开血流并到达受影响的组织。

6.Researchers observed that the rate of diapedesis (渗出) increased significantly in response to cytokine release.

研究人员观察到，细胞因子释放后diapedesis（渗出）的速度显著增加。

7.The phenomenon of diapedesis (渗出) is essential for the healing process as it allows immune cells to reach damaged tissues.

这一diapedesis（渗出）现象对愈合过程至关重要，因为它允许免疫细胞到达受损的组织。

作文

In the intricate world of human physiology, the movement of cells plays a crucial role in maintaining health and combating disease. One of the fascinating processes involved in this cellular movement is called diapedesis, which refers to the passage of blood cells, especially white blood cells, through the intact walls of the capillaries into the surrounding tissues. This process is essential for the immune response, allowing immune cells to reach sites of infection or injury swiftly. Understanding diapedesis is vital for comprehending how our body reacts to pathogens and heals itself after injuries.The term diapedesis is derived from the Greek words 'dia,' meaning 'through,' and 'pedesis,' meaning 'leaping.' This etymology reflects the dynamic nature of the process, where cells essentially 'leap' out of blood vessels to perform their functions. When an infection occurs, signals are sent out by damaged tissues, prompting nearby blood vessels to expand and become more permeable. This permeability allows white blood cells, or leukocytes, to exit the bloodstream and enter the affected tissue, where they can attack pathogens and facilitate healing.During diapedesis, leukocytes undergo several steps, including rolling along the endothelium, adhering to it, and finally squeezing through the gaps between endothelial cells. This sequence is tightly regulated by various signaling molecules and adhesion proteins. For example, selectins and integrins are critical in mediating the adhesion and migration of leukocytes. The ability of these immune cells to perform diapedesis effectively is crucial for a successful immune response. If this process is impaired, it can lead to chronic inflammation or inadequate immune responses, making the body more susceptible to infections.Moreover, diapedesis is not only important in the context of immune response but also plays a significant role in tissue repair and regeneration. After an injury, various growth factors and cytokines are released, stimulating the migration of cells to the site of damage. These cells include not only immune cells but also fibroblasts and endothelial cells, which are essential for wound healing and tissue regeneration. The coordinated action of these cells, facilitated by diapedesis, ensures that the body can efficiently repair itself after injury.Research on diapedesis has significant implications for medical science. Understanding this process can help develop new therapeutic strategies for treating inflammatory diseases, autoimmune disorders, and even cancer. For instance, if we can find ways to enhance or inhibit diapedesis, we may be able to control inflammation more effectively or prevent cancer cells from spreading throughout the body.In conclusion, diapedesis is a fundamental biological process that enables immune cells to respond to infections and facilitates tissue repair. Its complexity and importance highlight the remarkable capabilities of our immune system and the intricate interplay between different cell types in maintaining homeostasis. As research continues to uncover the mechanisms behind diapedesis, we move closer to harnessing this knowledge for better health outcomes and innovative treatments for various diseases.

在人体生理学的复杂世界中，细胞的运动在维持健康和抵抗疾病方面起着至关重要的作用。涉及这一细胞运动的一个迷人过程被称为diapedesis，指的是血细胞，尤其是白血细胞，通过完整的毛细血管壁进入周围组织的过程。该过程对免疫反应至关重要，使免疫细胞能够迅速到达感染或损伤的部位。理解diapedesis对于理解我们的身体如何对病原体作出反应以及在受伤后如何自我修复至关重要。术语diapedesis源于希腊词'dia'，意为'通过'，以及'pedesis'，意为'跳跃'。这种词源反映了该过程的动态特性，细胞本质上是从血管“跳出”以执行其功能。当发生感染时，受损组织会发出信号，促使附近的血管扩张并变得更加通透。这种通透性允许白血细胞或白细胞退出血流并进入受影响的组织，在那里它们可以攻击病原体并促进愈合。在diapedesis过程中，白血细胞经历多个步骤，包括沿内皮滚动、附着于内皮，最终挤过内皮细胞之间的缝隙。这个序列由各种信号分子和粘附蛋白严格调控。例如，选择素和整合素在介导白血细胞的附着和迁移中起着关键作用。这些免疫细胞有效执行diapedesis的能力对成功的免疫反应至关重要。如果这一过程受到损害，可能导致慢性炎症或免疫反应不足，使身体更易受到感染。此外，diapedesis不仅在免疫反应中重要，而且在组织修复和再生中也发挥着重要作用。在受伤后，各种生长因子和细胞因子被释放，刺激细胞向损伤部位迁移。这些细胞不仅包括免疫细胞，还包括成纤维细胞和内皮细胞，它们对伤口愈合和组织再生至关重要。通过diapedesis促进这些细胞的协调作用，确保身体能够有效地在受伤后自我修复。对diapedesis的研究对医学科学具有重要意义。理解这一过程可以帮助开发新的治疗策略，以治疗炎症性疾病、自身免疫疾病甚至癌症。例如，如果我们能够找到增强或抑制diapedesis的方法，我们可能能够更有效地控制炎症或防止癌细胞在全身扩散。总之，diapedesis是一个基本的生物过程，使免疫细胞能够对感染作出反应并促进组织修复。它的复杂性和重要性突显了我们免疫系统的非凡能力，以及不同细胞类型在维持稳态中的复杂相互作用。随着研究不断揭示diapedesis背后的机制，我们离利用这一知识实现更好的健康结果和创新治疗各种疾病的目标越来越近。