antithrombin

简明释义

英[ˌæntɪˈθrɒmbɪn]美[ænˈtɪθrɑːmbɪn]

n. [生化] 抗凝血酶（一种产生与肝脏的抗酶，能抑制血清中的凝血酶活化，从而防止纤维蛋白的形成）

英英释义

单词用法

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例句

1.Researchers have used the interaction between a polysaccharide called heparin and a peptide fragment of a protein called antithrombin III, which is contained in the bloodstream to control clotting.

研究者利用了肝素（一种多糖）和血液中的抗凝血酶III（一种多肽片断）之间的相互作用来控制凝固时间。

2.Conclusions venous thrombosis can result in decreased antithrombin activity, and increased lupus_like anticoagulants is one of the factors that lead to venous thrombosis.

结论静脉血栓形成可导致抗凝血酶活性下降，狼疮样抗凝物质增多是导致静脉血栓形成的因素之一。

3.The researchers attached heparin-binding peptides from antithrombin III to a synthetic material called polyethylene glycol.

研究人员将抗凝血酶III上的肝素结合肽段黏附在称为聚乙二醇的人工合成材料上。

4.Heterozygous type I (quantitative) and most type II (qualitative) antithrombin deficiencies highly increase the risk of venous thromboembolism (VTE), while homozygous mutations are lethal.

杂合子i型(定量)和大多数II型(定性)抗凝血酶缺乏症使静脉血栓栓塞(VTE)的风险显着增加，而纯合型突变会导致死亡。

5.Researchers have used the interaction between a polysaccharide called heparin and a peptide fragment of a protein called antithrombin III, which is contained in the bloodstream to control clotting.

研究者利用了肝素（一种多糖）和血液中的抗凝血酶III（一种多肽片断）之间的相互作用来控制凝固时间。

6.AIM To investigate the association between antithrombin activity at admission to the ICU(ICU-antithrombin activity) and various outcome variables.

目的观察患者回到ICU后的抗凝血酶活性以及术后各种不良结果的联系。

7.The doctor explained that a deficiency in antithrombin 抗凝血酶 can lead to an increased risk of blood clots.

医生解释说，抗凝血酶 antithrombin 的缺乏会导致血栓风险增加。

8.In cases of severe liver disease, antithrombin 抗凝血酶 production may be impaired.

在严重肝病的情况下，抗凝血酶 antithrombin 的产生可能受到影响。

9.A blood test can measure the levels of antithrombin 抗凝血酶 in the body.

血液测试可以测量体内的抗凝血酶 antithrombin 水平。

10.Some medications can affect the function of antithrombin 抗凝血酶, increasing the risk of thrombosis.

某些药物可能会影响抗凝血酶 antithrombin 的功能，增加血栓形成的风险。

11.Patients with hereditary antithrombin 抗凝血酶 deficiency may require anticoagulant therapy.

患有遗传性抗凝血酶 antithrombin 缺乏症的患者可能需要抗凝治疗。

作文

The human body is a complex system that relies on various proteins to maintain balance and functionality. One such crucial protein is antithrombin, which plays a significant role in the regulation of blood coagulation. Understanding antithrombin is essential for both medical professionals and the general public, as it helps to prevent excessive clotting in the bloodstream, which can lead to serious health issues. Antithrombin is a glycoprotein produced mainly in the liver, and it functions by inhibiting several key enzymes involved in the coagulation cascade, particularly thrombin and factor Xa. This inhibition is vital because it ensures that blood clots do not form unnecessarily, which could obstruct blood flow and result in conditions like deep vein thrombosis or pulmonary embolism. The importance of antithrombin is highlighted in various medical conditions. For instance, individuals with a deficiency in antithrombin are at a higher risk for developing thromboembolic disorders. This deficiency can be inherited or acquired due to other medical conditions, such as liver disease or during pregnancy. When antithrombin levels are low, the body's ability to regulate clot formation is compromised, leading to an increased likelihood of clotting events. Consequently, patients with antithrombin deficiency may require anticoagulant therapy to manage their condition effectively. Moreover, the role of antithrombin extends beyond just preventing clots. It also has implications in various surgical procedures and treatments. For example, during surgeries that involve significant blood loss or manipulation of blood vessels, maintaining adequate levels of antithrombin is critical to prevent postoperative complications. Medical professionals often monitor antithrombin levels in patients undergoing major surgeries to ensure that they remain within a safe range. In recent years, research has expanded our understanding of antithrombin and its potential therapeutic applications. Studies have shown that recombinant forms of antithrombin can be used to treat patients with congenital deficiencies or those experiencing acute thrombotic events. This innovative approach highlights the importance of antithrombin not only as a regulator of coagulation but also as a target for therapeutic intervention. In conclusion, antithrombin is a vital component of the body's hemostatic system, ensuring that blood clotting occurs appropriately without leading to excessive thrombus formation. Its role in preventing thromboembolic disorders and its implications in surgical settings underscore the need for a comprehensive understanding of this protein. As research continues to uncover new insights into antithrombin, its significance in both health and disease will undoubtedly become even more pronounced, making it a topic worthy of further exploration and attention in the medical field.

人体是一个复杂的系统，依赖于各种蛋白质来维持平衡和功能。其中一种重要的蛋白质是抗凝血酶，它在血液凝固的调节中发挥着重要作用。理解抗凝血酶对于医学专业人员和公众来说都是至关重要的，因为它有助于防止血液中过度凝结，这可能导致严重的健康问题。抗凝血酶是一种主要在肝脏中产生的糖蛋白，它通过抑制几个关键的凝血酶酶来发挥作用，特别是凝血酶和因子Xa。这种抑制是至关重要的，因为它确保血块不会不必要地形成，从而阻碍血流并导致深静脉血栓或肺栓塞等疾病。抗凝血酶的重要性在各种医疗条件中得到了强调。例如，缺乏抗凝血酶的个体更容易发展成血栓栓塞性疾病。这种缺乏可以是遗传性的，也可以是由于其他医疗条件引起的，例如肝病或妊娠。当抗凝血酶水平低时，身体调节凝血形成的能力受到损害，从而增加了血块事件的可能性。因此，缺乏抗凝血酶的患者可能需要抗凝治疗来有效管理他们的病情。此外，抗凝血酶的作用不仅限于预防血块。它在各种外科手术和治疗中的影响也很重要。例如，在涉及大量失血或操纵血管的手术中，维持足够的抗凝血酶水平对于防止术后并发症至关重要。医疗专业人员通常会监测接受重大手术的患者的抗凝血酶水平，以确保它们保持在安全范围内。近年来，研究扩展了我们对抗凝血酶及其潜在治疗应用的理解。研究表明，重组形式的抗凝血酶可以用于治疗先天性缺乏症患者或那些经历急性血栓事件的患者。这种创新的方法突显了抗凝血酶不仅作为凝血调节剂的重要性，还作为治疗干预的目标。总之，抗凝血酶是身体止血系统的重要组成部分，确保血液凝固适当地发生，而不会导致过度的血栓形成。它在预防血栓栓塞性疾病和外科设置中的作用强调了全面理解这种蛋白质的必要性。随着研究不断揭示对抗凝血酶的新见解，它在健康和疾病中的重要性无疑将更加突出，使其成为医学领域进一步探索和关注的主题。