prodrug

简明释义

英[ˈprəʊˌdrʌɡ]美[ˈproˌdrʌɡ]

n. 前体药物，药物前体；前药

英英释义

单词用法

同义词

反义词

例句

1.The invention further provides the application of the liver targeting anticancer nanometer prodrug system basing on the dendritic polymer in the preparation of drugs for treating solid tumors.

本发明还提供了一种基于树形聚合物肝靶向抗癌纳米前药系统在制备治疗实体肿瘤药物中的应用。

2.The flowable composition includes a biodegradable, thermoplastic polymer, an organic liquid, and risperidone, a metabolite, or a prodrug thereof.

所述可流动组合物包含可生物降解热塑性聚合物，有机液体和利培酮、其代谢物或前药。

3.Every proton pump inhibitor so far developed is administered in a prodrug form.

迄今为止每个质子泵抑制剂都被研究开发为一个前药的管理形式。

4.Mycophenolate mofetil, the prodrug of the 2-(4morpholino) ethyl ester of mycophenolic acid, has been widely applied to the prophylaxis of acute graft rejection in solid organ transplantation.

麦考酚吗乙酯是麦考酚酸的2-乙基酯前体药物，临床广泛应用于器官移植后的抗排斥治疗。

5.The prodrug exposed to strong acid is protonated and undergoes a conformational change to its active form which is capable of inhibiting the proton pump.

前药的接触了强酸后被质子化，并且经过结构的改变成为真正能够抑制质子泵的活化形式。

6.Preferably, the active drug is more than about 10 times as active as the prodrug.

优选地，活性药物 的活性比前体药物高约10倍以上。

7.AIM: to investigate the synthesis and colon targeted characteristics of pectin ketoprofen prodrug.

目的：合成果胶酮洛芬前药并进行体外评价。

8.Gel permeation chromatography (GPC) was used to determine the molecular weight of the prodrug.

利用凝胶渗透色谱(GPC)测定了前药的分子量。

9.Conclusion The results show that prednisolone can be delivered to large intestine by synthesized prednisolone prodrug, which has a potential in treatment of colitis.

结论泼尼松龙前体药物具一定结肠定位性，有可能成为一种具有应用前景的结肠炎治疗药物。

10.The development of prodrugs 前药 can help improve the bioavailability of certain medications.

开发前药 prodrugs 可以帮助改善某些药物的生物利用度。

11.Some cancer therapies utilize prodrugs 前药 to enhance drug delivery to tumors.

一些癌症治疗利用前药 prodrugs 来增强药物对肿瘤的输送。

12.A common example of a prodrug 前药 is codeine, which is metabolized into morphine in the body.

一个常见的前药 prodrug 的例子是可待因，它在体内被代谢为吗啡。

13.Valacyclovir is an antiviral prodrug 前药 that converts to acyclovir in the body.

伐昔洛韦是一种抗病毒的前药 prodrug，在体内转化为阿昔洛韦。

14.Using prodrugs 前药 can reduce side effects by targeting the active drug release.

使用前药 prodrugs 可以通过靶向活性药物释放来减少副作用。

作文

In the field of pharmacology, the term prodrug refers to a medication that is administered in an inactive or less active form. Once inside the body, it undergoes metabolic conversion into its active form. This concept is crucial for drug design and development as it allows for improved bioavailability, targeted delivery, and reduced side effects. For instance, some drugs may be poorly absorbed in their active form due to solubility issues or rapid metabolism. By utilizing a prodrug, researchers can enhance the drug's effectiveness by ensuring that it is converted into its active state only when needed. One of the most well-known examples of a prodrug is codeine. Codeine itself is not very effective as a pain reliever; however, when it is metabolized by the liver, it converts into morphine, which provides significant analgesic effects. This conversion process illustrates how prodrugs can be strategically designed to optimize therapeutic outcomes. The advantages of using prodrugs extend beyond just improving efficacy. They can also help in minimizing adverse effects. For example, some active drugs may cause gastrointestinal irritation or other side effects if taken directly. By administering a prodrug, the drug can be absorbed in a way that mitigates these side effects, as the active compound is only released at specific sites within the body. Moreover, prodrugs can enhance patient compliance. Patients are more likely to adhere to treatment regimens that involve medications with fewer side effects or those that require less frequent dosing. This is particularly important in chronic conditions where long-term medication is necessary. For instance, certain antiretroviral drugs used in the treatment of HIV are designed as prodrugs to improve their absorption and allow for once-daily dosing, which significantly enhances patient adherence to therapy. However, the design and development of prodrugs come with challenges. Scientists must carefully consider the metabolic pathways involved in converting the prodrug to its active form. If the conversion is too rapid, it could lead to toxicity, while slow conversion may result in insufficient therapeutic effect. Therefore, a thorough understanding of human biochemistry and pharmacokinetics is essential in the creation of effective prodrugs. In conclusion, the concept of prodrug plays a vital role in modern medicine. By transforming inactive compounds into therapeutically active drugs, prodrugs offer significant benefits in terms of efficacy, safety, and patient compliance. As research continues to advance in this field, we can expect to see more innovative prodrugs being developed, ultimately improving treatment options for various medical conditions. Understanding the role of prodrugs in pharmacotherapy is essential for healthcare professionals and patients alike, as it highlights the complexities and innovations present in modern medicine.

在药理学领域，术语前药指的是以无活性或活性较低的形式给药的药物。一旦进入体内，它会经过代谢转化为其活性形式。这个概念对于药物设计和开发至关重要，因为它可以提高生物利用度、靶向递送和减少副作用。例如，有些药物在其活性形式下可能由于溶解性问题或快速代谢而被吸收不良。通过使用前药，研究人员可以通过确保药物仅在需要时转化为其活性状态来增强药物的有效性。一个众所周知的前药的例子是可待因。可待因本身作为止痛药效果不是很好；然而，当它在肝脏中代谢时，会转化为吗啡，提供显著的镇痛效果。这一转化过程说明了前药如何被战略性地设计以优化治疗结果。使用前药的优势不仅限于提高疗效。它们还可以帮助减少不良反应。例如，一些活性药物如果直接服用可能会引起胃肠刺激或其他副作用。通过给药前药，药物可以以减轻这些副作用的方式被吸收，因为活性化合物仅在体内特定部位释放。此外，前药还可以增强患者的依从性。患者更有可能遵循那些副作用较少或需要较少频率给药的药物治疗方案。这在需要长期用药的慢性病中尤为重要。例如，用于治疗HIV的某些抗逆转录病毒药物被设计为前药，以改善其吸收并允许每日一次给药，这大大增强了患者对治疗的依从性。然而，前药的设计和开发也面临挑战。科学家必须仔细考虑将前药转化为其活性形式所涉及的代谢途径。如果转化过快，可能导致毒性，而转化过慢则可能导致治疗效果不足。因此，在创建有效的前药时，深入了解人类生物化学和药代动力学至关重要。总之，前药的概念在现代医学中发挥着重要作用。通过将无活性化合物转化为治疗活性药物，前药在疗效、安全性和患者依从性方面提供了显著的好处。随着这一领域研究的不断进展，我们可以期待看到更多创新的前药被开发出来，最终改善各种疾病的治疗选择。理解前药在药物治疗中的作用对于医疗专业人员和患者来说都是至关重要的，因为它突显了现代医学中存在的复杂性和创新。