quinolinic acid

简明释义

喹啉酸

英英释义

例句

1.Studies suggest that quinolinic acid 喹啉酸 may play a role in mood disorders.

研究表明，quinolinic acid 喹啉酸可能在情绪障碍中发挥作用。

2.The synthesis of quinolinic acid 喹啉酸 can occur through the metabolism of tryptophan.

通过色氨酸的代谢可以合成quinolinic acid 喹啉酸。

3.Research has shown that quinolinic acid 喹啉酸 levels are elevated in patients with neurodegenerative diseases.

研究表明，患有神经退行性疾病的患者体内的quinolinic acid 喹啉酸水平升高。

4.High concentrations of quinolinic acid 喹啉酸 can lead to excitotoxicity in neurons.

高浓度的quinolinic acid 喹啉酸可能导致神经元的兴奋性毒性。

5.The role of quinolinic acid 喹啉酸 in the central nervous system is still being investigated.

在中枢神经系统中quinolinic acid 喹啉酸的作用仍在研究中。

作文

Quinolinic acid, a compound derived from the metabolism of the amino acid tryptophan, plays a significant role in various biochemical processes within the human body. It is an intermediate in the kynurenine pathway, which is the primary route for the degradation of tryptophan. This pathway is crucial not only for energy production but also for the synthesis of important neurotransmitters. Understanding the functions and implications of quinolinic acid (喹啉酸) is essential for grasping its impact on health and disease.Research has shown that quinolinic acid (喹啉酸) can have neurotoxic effects, particularly in the context of neurological disorders such as Alzheimer's disease and multiple sclerosis. Elevated levels of quinolinic acid (喹啉酸) have been found in the brains of individuals suffering from these conditions, suggesting that it may contribute to neuronal damage. The mechanism behind this toxicity involves the activation of NMDA receptors, which, when overstimulated, can lead to excitotoxicity and subsequent neuronal death.Moreover, quinolinic acid (喹啉酸) has been implicated in the modulation of immune responses. It can influence the activity of microglia, the resident immune cells in the brain. When activated, microglia can release inflammatory cytokines that can exacerbate neurodegenerative processes. Therefore, understanding how quinolinic acid (喹啉酸) interacts with the immune system is vital for developing therapeutic strategies aimed at mitigating its harmful effects.In addition to its pathological roles, quinolinic acid (喹啉酸) also has potential therapeutic applications. For instance, it has been studied for its role in enhancing cognitive function and mood regulation. Some research suggests that low doses of quinolinic acid (喹啉酸) might have neuroprotective properties, possibly by promoting the survival of neurons under stress conditions. This dual nature of quinolinic acid (喹啉酸)—being both potentially harmful and beneficial—highlights the complexity of its role in the body.The balance of quinolinic acid (喹啉酸) levels is crucial. Factors such as diet, lifestyle, and genetics can influence its concentration in the body. For example, diets rich in tryptophan can lead to increased production of quinolinic acid (喹啉酸), which may be beneficial in some contexts but detrimental in others. Thus, maintaining an optimal level of this compound is essential for overall health.In conclusion, quinolinic acid (喹啉酸) is a multifaceted compound with significant implications for both health and disease. Its involvement in neurotoxicity, immune modulation, and potential therapeutic effects makes it a critical subject of study in biochemistry and medicine. As research progresses, a deeper understanding of quinolinic acid (喹啉酸) will undoubtedly lead to new insights into treating various neurological conditions and improving cognitive health.

喹啉酸是从氨基酸色氨酸的代谢中衍生出来的化合物，在人体内的各种生化过程中扮演着重要角色。它是犬尿氨酸途径中的一个中间产物，该途径是色氨酸降解的主要途径。这一途径不仅对能量产生至关重要，还对重要神经递质的合成具有重要意义。理解喹啉酸在健康和疾病中的影响是至关重要的。研究表明，喹啉酸可能具有神经毒性，特别是在阿尔茨海默病和多发性硬化症等神经系统疾病的背景下。在这些疾病患者的大脑中发现了升高的喹啉酸水平，这表明它可能会导致神经元损伤。这种毒性的机制涉及NMDA受体的激活，当其过度刺激时，会导致兴奋性毒性和随后的神经元死亡。此外，喹啉酸还与免疫反应的调节有关。它可以影响小胶质细胞的活动，小胶质细胞是大脑中的常驻免疫细胞。当被激活时，小胶质细胞可以释放炎症细胞因子，从而加剧神经退行性过程。因此，了解喹啉酸如何与免疫系统相互作用，对于开发旨在减轻其有害影响的治疗策略至关重要。除了其病理作用外，喹啉酸还具有潜在的治疗应用。例如，它在增强认知功能和情绪调节方面得到了研究。一些研究表明，低剂量的喹啉酸可能具有神经保护特性，可能通过促进神经元在压力条件下的存活来实现。这种双重性质的喹啉酸——既可能有害又可能有益——突显了其在体内角色的复杂性。喹啉酸水平的平衡至关重要。饮食、生活方式和遗传等因素都可以影响其在体内的浓度。例如，富含色氨酸的饮食可能导致喹啉酸的产量增加，这在某些情况下可能是有益的，但在其他情况下则可能有害。因此，维持这种化合物的最佳水平对整体健康至关重要。总之，喹啉酸是一种多面化合物，对健康和疾病具有重要影响。它在神经毒性、免疫调节和潜在治疗效果方面的参与，使其成为生物化学和医学研究的重要主题。随着研究的进展，对喹啉酸的深入理解无疑将为治疗各种神经系统疾病和改善认知健康提供新的见解。