arsenic trioxide

简明释义

三氧化二砷

英英释义

例句

1.In some regions, arsenic trioxide is used in traditional medicine, but caution is advised.

在某些地区，三氧化二砷被用于传统医学，但建议谨慎使用。

2.The chemist carefully handled arsenic trioxide to ensure safety in the laboratory.

化学家小心翼翼地处理三氧化二砷以确保实验室的安全。

3.Researchers are exploring the potential of arsenic trioxide in cancer treatment.

研究人员正在探索三氧化二砷在癌症治疗中的潜力。

4.Proper disposal of arsenic trioxide is crucial to prevent environmental contamination.

妥善处理三氧化二砷对于防止环境污染至关重要。

5.The environmental study revealed high levels of arsenic trioxide in the water supply.

环境研究显示水供应中含有高水平的三氧化二砷。

作文

Arsenic trioxide, known chemically as As2O3, is a compound that has garnered significant attention in both scientific and medical fields. This white powder is primarily recognized for its use in the treatment of acute promyelocytic leukemia (APL), a type of blood cancer. The effectiveness of arsenic trioxide (三氧化二砷) in treating APL was first established in clinical studies during the late 1990s, marking a pivotal moment in oncological therapies. Unlike traditional chemotherapy, which often targets rapidly dividing cells indiscriminately, arsenic trioxide (三氧化二砷) specifically induces apoptosis, or programmed cell death, in malignant cells. This targeted approach not only enhances the efficacy of treatment but also minimizes damage to healthy cells, leading to fewer side effects for patients.The mechanism of action of arsenic trioxide (三氧化二砷) involves multiple pathways. It disrupts the function of the promyelocytic leukemia-retinoic acid receptor alpha (PML-RARA) fusion protein, which plays a crucial role in the pathogenesis of APL. By promoting the degradation of this protein, arsenic trioxide (三氧化二砷) restores normal myeloid differentiation and leads to the death of leukemic cells. This has made it an invaluable tool in the arsenal against APL, particularly for patients who have relapsed or are resistant to other forms of treatment.However, the use of arsenic trioxide (三氧化二砷) is not without challenges. One of the primary concerns is its potential toxicity. Patients undergoing treatment may experience side effects such as QT interval prolongation, which can lead to serious cardiac complications. Therefore, careful monitoring of heart function is essential during therapy. Additionally, the long-term effects of arsenic trioxide (三氧化二砷) remain an area of ongoing research, as understanding these effects is crucial for developing comprehensive treatment plans that prioritize patient safety.Beyond its medical applications, arsenic trioxide (三氧化二砷) has been studied for its properties in various industrial contexts. Historically, it has been used in the production of glass and as a pesticide. However, due to its toxic nature, the use of arsenic trioxide (三氧化二砷) in these industries has significantly declined, with many countries imposing strict regulations on its use. This shift reflects a growing awareness of environmental and health risks associated with arsenic compounds.In conclusion, arsenic trioxide (三氧化二砷) represents a fascinating intersection of chemistry, medicine, and safety. Its role in treating APL has transformed the landscape of hematological oncology, offering hope to patients facing a challenging diagnosis. As research continues to unveil the complexities of this compound, it is imperative that we balance its therapeutic benefits with the potential risks it poses. Ongoing studies will undoubtedly enhance our understanding of arsenic trioxide (三氧化二砷) and pave the way for safer and more effective treatments in the future.

三氧化二砷，化学上称为As2O3，是一种在科学和医学领域引起重大关注的化合物。这种白色粉末主要因其在治疗急性前髓细胞白血病（APL）中的应用而受到认可，这是一种血液癌症。三氧化二砷（arsenic trioxide）在治疗APL方面的有效性是在1990年代末的临床研究中首次确立的，标志着肿瘤治疗的重要时刻。与传统化疗不同，后者往往不加区分地靶向快速分裂的细胞，三氧化二砷（arsenic trioxide）特定地诱导恶性细胞的凋亡或程序性细胞死亡。这种靶向方法不仅提高了治疗的有效性，还最小化了对健康细胞的损害，从而使患者的副作用更少。三氧化二砷（arsenic trioxide）的作用机制涉及多条途径。它干扰前髓细胞白血病-视黄酸受体α（PML-RARA）融合蛋白的功能，该蛋白在APL的发病机制中发挥着关键作用。通过促进该蛋白的降解，三氧化二砷（arsenic trioxide）恢复正常的骨髓分化，并导致白血病细胞的死亡。这使其成为对抗APL的重要工具，特别是对于那些复发或对其他治疗形式产生耐药的患者。然而，使用三氧化二砷（arsenic trioxide）并非没有挑战。一个主要的担忧是其潜在的毒性。接受治疗的患者可能会经历QT间期延长等副作用，这可能导致严重的心脏并发症。因此，在治疗过程中仔细监测心脏功能至关重要。此外，三氧化二砷（arsenic trioxide）的长期影响仍然是一个持续研究的领域，因为理解这些影响对于制定优先考虑患者安全的综合治疗计划至关重要。除了医学应用外，三氧化二砷（arsenic trioxide）还因其在各种工业背景下的特性而受到研究。历史上，它曾用于玻璃生产和作为农药。然而，由于其毒性，许多国家对其使用施加了严格的监管。这一转变反映了人们对与砷化合物相关的环境和健康风险日益增长的认识。总之，三氧化二砷（arsenic trioxide）代表了化学、医学和安全性的迷人交集。它在治疗APL中的作用改变了血液肿瘤学的格局，为面临挑战性诊断的患者带来了希望。随着研究继续揭示该化合物的复杂性，我们必须平衡其治疗益处与潜在风险。持续的研究无疑将增强我们对三氧化二砷（arsenic trioxide）的理解，并为未来更安全、更有效的治疗铺平道路。