threshold dose

简明释义

临界剂量

英英释义

例句

1.The study determined that the threshold dose 阈值剂量 for this medication is 50 mg per day.

研究确定该药物的threshold dose 阈值剂量为每天50毫克。

2.Patients should not exceed the threshold dose 阈值剂量 to avoid adverse effects.

患者不应超过threshold dose 阈值剂量以避免不良反应。

3.The threshold dose 阈值剂量 for toxicity was established at 10 mg/kg in animal studies.

在动物研究中，毒性的threshold dose 阈值剂量被确定为每公斤10毫克。

4.Understanding the threshold dose 阈值剂量 is crucial for safe medication administration.

了解threshold dose 阈值剂量对于安全用药至关重要。

5.Researchers are investigating how the threshold dose 阈值剂量 varies among different populations.

研究人员正在调查不同人群中threshold dose 阈值剂量的变化。

作文

In the field of pharmacology and toxicology, the concept of threshold dose plays a critical role in determining the safety and efficacy of substances. The term threshold dose refers to the minimum amount of a substance that produces a noticeable effect in an organism. Understanding this concept is vital for researchers, healthcare professionals, and regulatory agencies as they assess the potential risks and benefits associated with exposure to various chemicals, medications, and environmental agents.For instance, when developing new drugs, scientists must identify the threshold dose at which the drug begins to exhibit therapeutic effects without causing adverse reactions. This involves rigorous testing and clinical trials to ensure that the dosage is safe for human consumption. If the dose is too low, the drug may not be effective; if it is too high, it may lead to toxicity. Therefore, pinpointing the threshold dose is essential for optimizing treatment regimens.Moreover, the threshold dose is not a fixed value; it can vary significantly between individuals due to factors such as age, weight, genetic predisposition, and overall health. For example, what may be a safe threshold dose for one person could be harmful to another. This variability underscores the importance of personalized medicine, where treatments are tailored to the individual characteristics of each patient.In the context of environmental health, the threshold dose is crucial for assessing the impact of pollutants on human health. Regulatory bodies often establish guidelines that specify acceptable levels of exposure to hazardous substances based on their threshold doses. For example, the Environmental Protection Agency (EPA) sets limits on the concentration of certain chemicals in drinking water to protect public health. These limits are derived from studies that identify the threshold dose associated with adverse health effects.Additionally, understanding the threshold dose can help inform public health policies and preventive measures. For instance, during an epidemic, health officials may need to determine the threshold dose of a vaccine that will elicit an adequate immune response in the population. By analyzing data from clinical trials, they can establish the optimal dosage to ensure maximum protection against the disease while minimizing side effects.Education about the threshold dose is also important for the general public. Many people may not be aware of how different substances can affect their health. By raising awareness about the concept of threshold dose, individuals can make informed decisions regarding their exposure to various chemicals, whether in food, air, or consumer products.In conclusion, the threshold dose is a fundamental concept in pharmacology and toxicology that helps determine the safety and effectiveness of substances. Its implications extend beyond the laboratory, influencing drug development, environmental regulations, and public health policies. As our understanding of the threshold dose continues to evolve, it is essential for both professionals and the public to remain informed about its significance in safeguarding health and well-being.

在药理学和毒理学领域，阈值剂量的概念在确定物质的安全性和有效性方面起着至关重要的作用。术语阈值剂量指的是产生可察觉效果所需的最小物质量。在评估与各种化学物质、药物和环境因子接触相关的潜在风险和益处时，理解这一概念对研究人员、医疗保健专业人员和监管机构至关重要。例如，在开发新药时，科学家必须确定药物开始表现出治疗效果而不引起不良反应的阈值剂量。这涉及严格的测试和临床试验，以确保剂量对人类消费是安全的。如果剂量过低，药物可能无效；如果剂量过高，则可能导致毒性。因此，确定阈值剂量对于优化治疗方案至关重要。此外，阈值剂量并不是一个固定值；由于年龄、体重、遗传倾向和整体健康状况等因素，它在个体之间可能有显著差异。例如，对于一个人来说，安全的阈值剂量可能对另一个人有害。这种变异性强调了个性化医学的重要性，即根据每位患者的个体特征量身定制治疗。在环境健康的背景下，阈值剂量对于评估污染物对人类健康的影响至关重要。监管机构通常会根据其阈值剂量建立指南，规定对有害物质的可接受接触水平。例如，环境保护局（EPA）设定饮用水中某些化学物质的浓度限制，以保护公众健康。这些限制源于识别与不良健康影响相关的阈值剂量的研究。此外，理解阈值剂量可以帮助指导公共卫生政策和预防措施。例如，在疫情期间，卫生官员可能需要确定疫苗的阈值剂量，以在群体中引发足够的免疫反应。通过分析临床试验的数据，他们可以建立最佳剂量，以确保最大程度地保护人们免受疾病影响，同时最小化副作用。提高公众对阈值剂量的认识也很重要。许多人可能不知道不同物质如何影响他们的健康。通过提高对阈值剂量概念的认识，个人可以就接触各种化学物质做出明智的决定，无论是在食品、空气或消费品中。总之，阈值剂量是药理学和毒理学中的一个基本概念，有助于确定物质的安全性和有效性。它的影响超越实验室，影响药物开发、环境法规和公共卫生政策。随着我们对阈值剂量的理解不断发展，专业人士和公众都必须保持对其在保护健康和福祉方面重要性的了解。