tautomeric change

简明释义

互变异构变化

英英释义

例句

1.The tautomeric change between keto and enol forms can significantly affect reactivity.

酮和烯醇形式之间的互变异构体变化可以显著影响反应性。

2.Researchers observed a tautomeric change in the compound during the experiment.

研究人员在实验过程中观察到化合物发生了互变异构体变化。

3.In organic chemistry, understanding tautomeric change is crucial for predicting the behavior of certain compounds.

在有机化学中，理解互变异构体变化对预测某些化合物的行为至关重要。

4.A detailed study on tautomeric change revealed new insights into molecular stability.

关于互变异构体变化的详细研究揭示了分子稳定性的新见解。

5.The reaction mechanism involves a tautomeric change that stabilizes the intermediate compound.

反应机制涉及一个互变异构体变化，这使中间化合物稳定。

作文

Tautomeric change is a fundamental concept in organic chemistry that refers to the structural rearrangement of molecules. This process occurs when a compound exists in two or more interconvertible forms, known as tautomers, which differ primarily in the position of protons and the connectivity of atoms. Understanding tautomeric change (互变异构) is crucial for chemists, as it plays a significant role in various chemical reactions and biological processes.To illustrate this concept, let us consider the example of keto-enol tautomerism. In this case, a ketone and its corresponding enol can interconvert through tautomeric change (互变异构). The keto form contains a carbonyl group (C=O), while the enol form has a hydroxyl group (–OH) attached to a carbon-carbon double bond. This transformation is not merely a simple shift; it involves the migration of a hydrogen atom and the reorganization of the double bond. The equilibrium between the keto and enol forms is influenced by several factors, including solvent effects, temperature, and the presence of catalysts.The importance of tautomeric change (互变异构) extends beyond theoretical chemistry. In biological systems, tautomerism can affect the function of biomolecules. For instance, the tautomeric forms of nucleobases in DNA can lead to mutations during DNA replication. If the wrong tautomer is incorporated into the growing DNA strand, it may result in base-pair mismatches, ultimately leading to genetic alterations. This highlights the significance of understanding tautomeric change (互变异构) in the context of molecular biology and genetics.Moreover, tautomeric change (互变异构) also has implications in drug design and development. Many pharmaceutical compounds exhibit tautomerism, and the different tautomeric forms can have varying biological activities. Therefore, medicinal chemists must consider the stability and reactivity of each tautomer when designing new drugs. By analyzing how tautomeric change (互变异构) impacts a drug's pharmacokinetics and pharmacodynamics, researchers can optimize therapeutic efficacy and minimize side effects.In conclusion, tautomeric change (互变异构) is an essential concept that underscores the dynamic nature of chemical compounds. It is not only relevant in academic research but also has practical applications in fields like biochemistry and pharmaceuticals. A deeper understanding of this phenomenon can lead to advancements in various scientific domains, enhancing our knowledge of molecular interactions and their consequences in both health and disease. As we continue to explore the complexities of chemical behavior, the study of tautomeric change (互变异构) will undoubtedly remain a vital area of investigation.

互变异构是有机化学中的一个基本概念，指的是分子的结构重排过程。当一个化合物以两种或多种可互相转化的形式存在时，就会发生这种过程，这些形式被称为互变异构体，它们主要在质子的位置和原子的连接性上有所不同。理解tautomeric change（互变异构）对化学家至关重要，因为它在各种化学反应和生物过程中发挥着重要作用。为了说明这一概念，我们可以考虑酮-烯醇互变异构的例子。在这种情况下，酮及其对应的烯醇可以通过tautomeric change（互变异构）相互转化。酮形式包含一个羰基（C=O），而烯醇形式则在碳-碳双键上附有一个羟基（–OH）。这种转变不仅仅是一个简单的位移；它涉及到氢原子的迁移和双键的重组。酮和烯醇形式之间的平衡受多种因素的影响，包括溶剂效应、温度以及催化剂的存在。tautomeric change（互变异构）的重要性超越了理论化学。在生物系统中，互变异构可能影响生物大分子的功能。例如，DNA中核苷酸的互变异构形式可能导致DNA复制过程中出现突变。如果在正在增长的DNA链中引入了错误的互变异构体，可能会导致碱基对不匹配，最终导致遗传改变。这突显了在分子生物学和遗传学背景下理解tautomeric change（互变异构）的重要性。此外，tautomeric change（互变异构）在药物设计和开发中也具有重要意义。许多药物化合物表现出互变异构，而不同的互变异构形式可能具有不同的生物活性。因此，药物化学家在设计新药时必须考虑每种互变异构体的稳定性和反应性。通过分析tautomeric change（互变异构）如何影响药物的药代动力学和药效学，研究人员可以优化治疗效果并最小化副作用。总之，tautomeric change（互变异构）是一个重要的概念，强调了化合物动态特性的本质。它不仅与学术研究相关，而且在生物化学和制药等领域具有实际应用。对这一现象的更深入理解可以推动各个科学领域的进步，增强我们对分子相互作用及其在健康和疾病中后果的认识。随着我们继续探索化学行为的复杂性，tautomeric change（互变异构）的研究无疑将继续成为一个重要的研究领域。